A5100415368- Cancer-related molecular mechanisms research
- Thyroid Cancer Diagnosis and Treatment
- Diamond and Carbon-based Materials Research
- Metal and Thin Film Mechanics
- RNA modifications and cancer
- Advanced Neuroimaging Techniques and Applications
- Semiconductor materials and devices
- Circular RNAs in diseases
- Cancer, Lipids, and Metabolism
- Ferroptosis and cancer prognosis
- Cerebrospinal fluid and hydrocephalus
- MicroRNA in disease regulation
- Traumatic Brain Injury and Neurovascular Disturbances
- Medical Imaging Techniques and Applications
- Safety Warnings and Signage
- Cancer Research and Treatments
- Liver physiology and pathology
- Advancements in Transdermal Drug Delivery
- Global Cancer Incidence and Screening
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- Immune cells in cancer
- Radiology practices and education
- Cytokine Signaling Pathways and Interactions
- RNA Research and Splicing
Shanghai Jiao Tong University
2020-2024
University of Cambridge
2022-2024
Shanghai Sixth People's Hospital
2020-2024
Zhejiang Chinese Medical University
2024
Wellcome/MRC Cambridge Stem Cell Institute
2022
Medical Research Council
2022
Peking University
2022
Peking University International Hospital
2022
First Hospital of China Medical University
2018-2022
China Medical University
2018-2022
ABSTRACT The trophoblast lineage safeguards fetal development by mediating embryo implantation, immune tolerance, nutritional supply and gas exchange. Human stem cells (hTSCs) provide a platform to study specification of placental tissues; however, the regulatory network controlling self-renewal remains elusive. Here, we present single-cell atlas human from zygote mid-gestation together with profiling hTSCs. We determine transcriptional networks lineages in vivo leverage probabilistic...
This study aimed to assess the diagnostic performance and added value radiologists of different levels a computer-aided diagnosis (CAD) system for detection thyroid cancers.303 patients who underwent thyroidectomy from October 2018 July 2019 were retrospectively reviewed. The senior radiologist, junior CAD compared. was assessed subgroup analyses performed according size nodules.In total, 186 malignant nodules, 179 benign nodules included; 168 papillary carcinoma (PTC), 7 medullary (MTC), 11...
Background/aim: Hepatic stellate cells (HSCs) are critical determinants of liver tumor behavior such as vascular invasion, cell proliferation and migration. The apoptosis HSCs can inhibit growth contribute to repressing hepatocellular carcinoma (HCC) progression. Our study aims investigate the impact nuclear glyceraldehyde-3-phosphate dehydrogenase (GAPDH) on under hypoxic conditions association GAPDH with HCC patient outcomes Patients methods: Following stable passage, 0.3% O 2 was used...
Osteosarcoma (OS) is a malignant tumor prevalent in adolescents; however, clinically effective treatment for this malignancy lacking. The lack of methods and factors, such as recurrence drug resistance, further dampen the prospect treating OS. In recent years, small molecule microRNAs (miRNAs) with length approximately 20-24 nucleotides have gradually attracted attention medical community. Studies found that miRNAs can regulate cell cycle, apoptosis, proliferation, proliferation. metabolic...
Abstract Background Cerebrospinal fluid (CSF) circulation is essential in removing metabolic wastes from the brain and an integral component of glymphatic system. Abnormal CSF implicated neurodegenerative diseases. Low b-value magnetic resonance imaging quantifies variance motion, or pseudodiffusivity. However, few studies have investigated relationship between spatial patterns pseudodiffusivity cognition. Methods We introduced a novel technique, CSF-based statistics (CBSS), to automatically...
Objectives To investigate the blood flow characteristics of polypoidal choroidal vasculopathy (PCV) using optical coherence tomography angiography (OCTA) and to analyse photodynamic therapy (PDT) effects on remodelling in PCV. Materials Methods Diagnostic indocyanine green OCTA were performed. All patients underwent PDT with full‐dose verteporfin followed up enhanced‐depth imaging tomography. Results At baseline, a branching vascular network (BVN) was clearly demonstrated all PCV who...
Hepatocellular carcinoma (HCC) is a common malignancy. However, the molecular mechanisms of progression and prognosis HCC remain unclear. In current study, we merged three Gene Expression Omnibus (GEO) datasets combined them with The Cancer Genome Atlas (TCGA) dataset to screen differentially expressed genes. Furthermore, protein‒protein interaction (PPI) weighted gene coexpression network analysis (WGCNA) were used identify key modules in HCC. Ontology (GO) Kyoto Encyclopedia Genes Genomes...
Glioma is one of the most common malignant tumors central nervous system with a poor prognosis at present due to lack effective treatment options. Its initiation, migration, and multipotency are affected by cancer stem cell’s transition. Previous studies imply that changes in cells can affect differentiation tumor. We found epithelial-to-mesenchymal transition (EMT)-related regulatory pathway an important target for tumor therapy. In this review, we discuss factor EMT 3 specific pathways...
Preoperative diagnosis for follicular thyroid cancer (FTC) remains challenging. The purpose of this study was to explore the maximum intensity projection (MIP) features, which can be utilized reconstructing and characterizing structure microvascular in tissue, associated with FTC, independent risk factors FTC combination multimodal ultrasonography blood indicators.
miR-339 has garnered significant attention due to its critical role in various physiological and pathological processes, demonstrating diverse functions potential applications biology medicine. This paper provides a comprehensive review of current research on miR-339, offering new strategies ideas for further exploration. By analyzing nearly 200 articles from PubMed, Web Science, other databases over the past 20 years, key information been extracted develop thorough understanding miR-339....
Motivation: Cerebrospinal fluid (CSF) circulation is crucial for removing waste from the brain, and abnormal CSF motion was associated with neurodegenerative diseases. This study aims to use low b-value diffusion MRI assess variance of CSF, i.e., pseudodiffusivity, investigate its association cognitive impairment. Goal(s): To quantify pseudodiffusivity within each sulcus, cistern ventricle. Approach: In 93 participants a memory clinic, Intravoxel incoherent (IVIM) performed measure...
Wisely differentiating high-risk papillary thyroid carcinoma (PTC) patients from low-risk PTC preoperatively is necessary when comes to making a personalized treatment plan. It not easy stratify the risk of according sonography or lab results before surgery. This study aims seek out potential mutation gene markers that may be helpful in stratifying PTC. A custom panel 439 relevant and classic tumor metabolic pathway genes was designed. Targeted capture sequencing performed on 35 pairs...