A5009140500- Spine and Intervertebral Disc Pathology
- Musculoskeletal pain and rehabilitation
- Spinal Cord Injury Research
- Scoliosis diagnosis and treatment
- Spinal Fractures and Fixation Techniques
- Medical Imaging and Analysis
- Plant Toxicity and Pharmacological Properties
- Pain Mechanisms and Treatments
- Cervical and Thoracic Myelopathy
- Autophagy in Disease and Therapy
- Spondyloarthritis Studies and Treatments
- Pregnancy-related medical research
- Heat shock proteins research
- MicroRNA in disease regulation
- Extracellular vesicles in disease
- Nerve injury and regeneration
- Connective tissue disorders research
- Neuroinflammation and Neurodegeneration Mechanisms
- Congenital Diaphragmatic Hernia Studies
- S100 Proteins and Annexins
- Cancer-related molecular mechanisms research
- Shoulder Injury and Treatment
- Mesenchymal stem cell research
- Plant-derived Lignans Synthesis and Bioactivity
- Orthopedic Infections and Treatments
Lanzhou University
2015-2025
Lanzhou University Second Hospital
2015-2025
China International Science and Technology Cooperation
2019-2024
Fudan University Shanghai Cancer Center
2023
Gansu Academy of Machinery Science
2021
The aim of this study was to examine whether tourniquet use can improve perioperative blood loss, early function recovery, and pain after primary total knee arthroplasty (TKA) in the setting multiple-dose intravenous tranexamic acid.This a prospective, randomized clinical trial including 180 patients undergoing TKA with multiple doses acid. One group treated during entire procedure, second received cementing, third did not receive tourniquet. All same protocol acid (20 mg/kg) before skin...
Intervertebral disc degeneration (IDD) is the most common chronic skeletal muscle disease. Although underlying mechanisms remain unclear, nucleus pulposus (NP) autophagy, senescence, and apoptosis are known to play a critical role in this process. Previous studies suggest that bromodomain-containing protein 4 (BRD4) promotes senescent apoptotic effects several age-related degenerative diseases. It not known, however, if BRD4 inhibition protective IDD. In study, we explored whether influenced...
Abstract Intervertebral disc (IVD) degeneration (IVDD) is closely linked to degenerative spinal disease, resulting in disability, poor quality of life, and financial burden. Apoptosis nucleus pulposus (NP) cells (NPCs) a key pathological basis IVDD. Periostin (POSTN), an extracellular matrix protein, expressed many tissues, whereas its abnormal expression associated with The conventional Wnt/β‐catenin pathway also involved IVDD contributes NPCs apoptosis. However, research on the mechanisms...
Low back pain is a common symptom of intervertebral disc degeneration (IDD), which seriously affects the quality life patients. The abnormal apoptosis and senescence nucleus pulposus (NP) cells play important roles in pathogenesis IDD. Proanthocyanidins (PACs) are polyphenolic compounds with anti-apoptosis anti-aging effects. However, their functions NP not yet clear. Therefore, this study was performed to explore effects PACs on cell aging underlying mechanisms action.Cell viability...
In this investigation, we administered oxidative stress to nucleus pulposus cells (NPCs), recognized DNA-damage-inducible transcript 4 (DDIT4) as a component in intervertebral disc degeneration (IVDD), and devised hydrogel capable of conveying small interfering RNA (siRNA) IVDD.