A5058917416- Dialysis and Renal Disease Management
- Chronic Kidney Disease and Diabetes
- Traditional Chinese Medicine Studies
- Ginkgo biloba and Cashew Applications
- Healthcare Systems and Reforms
- Chronic Disease Management Strategies
- Anesthesia and Pain Management
- RNA modifications and cancer
- Healthcare and Venom Research
- Blood Pressure and Hypertension Studies
- Gut microbiota and health
- Ferroptosis and cancer prognosis
- HVDC Systems and Fault Protection
- Central Venous Catheters and Hemodialysis
- Diabetes Management and Education
- Medical Research and Treatments
- Nanoplatforms for cancer theranostics
- Neurological Disease Mechanisms and Treatments
- Remote Sensing and Land Use
- Botulinum Toxin and Related Neurological Disorders
- Acute Kidney Injury Research
- Epigenetics and DNA Methylation
- Extracellular vesicles in disease
- Nephrotoxicity and Medicinal Plants
- Restless Legs Syndrome Research
Chongqing Medical University
2021-2025
The Affiliated Yongchuan Hospital of Chongqing Medical University
2021-2025
Guangzhou University of Chinese Medicine
2015-2024
Heilongjiang University
2024
Institute of Sugar Beet
2024
Guangdong Provincial Hospital of Traditional Chinese Medicine
2013-2023
Second Affiliated Hospital of Xinjiang Medical University
2023
Xinjiang Medical University
2023
China Southern Power Grid (China)
2021
The Royal Melbourne Hospital
2021
Traditional treatments against advanced non-small cell lung cancer (NSCLC) with high morbidity and mortality continue to be dissatisfactory. Given this situation, there is an urgent requirement for alternative modalities that provide lower invasiveness, superior clinical effectiveness, minimal adverse effects. The combination of photodynamic therapy (PDT) immunotherapy gradually become a promising approach high-grade malignant NSCLC. Nevertheless, owing the absence precise drug delivery...
Abstract Background The role of mitochondrial dynamics, encompassing fission, fusion, and mitophagy, in cancer progression has been extensively studied. However, the specific impact dynamics on hepatocellular carcinoma (HCC) is still under investigation. Methods In this study, dynamic genes were obtained from MitoCarta 3.0 database, gene expression data collected Cancer Genome Atlas (TCGA) database. Based these differentially expressed (DEGs), patients stratified into two clusters....
Objective: Diabetic kidney disease (DKD) has become the major cause of end-stage renal (ESRD) associated with progression fibrosis. As gut microbiota dysbiosis is closely related to damage and fibrosis, we investigated role microbiota-related serum metabolites in DKD this study. Methods: Fecal samples obtained from predialysis patients January 2017 December 2019 were detected using 16S rRNA gene sequencing liquid chromatography-mass spectrometry, respectively. Forty-one divided into two...
Context A Chinese herbal formula, Tiaopi Xiezhuo decoction (TXD), is developed from a classical prescription Sanhuang Xiexin decoction.Objective To investigate the regulatory effect of TXD on gut dysbiosis, as treatment constipation in patients with peritoneal dialysis (PD).Materials and methods The chemical content was assessed by high-performance liquid chromatography. total 29 PD were enrolled treated orally (3 g crude drug/each/twice/day) for 3 months. Blood faecal samples collected at...
Abstract Reprogramming in lipid metabolism is a hallmark of cancer, and targeting the pivotal enzyme fatty acid synthesis, acetyl‐CoA carboxylase 1 (ACC1), presents promising therapeutic strategy. Herein, nano‐cage encapsulated constructed by peptide‐modified erythrocyte membrane (NTA630‐NCs‐RBCM‐T) for delivering CRISPR‐Cas9 ACC1 inhibitors to enable dual‐layer inhibition ACC1, thereby optimizing effectiveness antitumor cascade therapy. NTA630‐NCs‐RBCM‐T are efficiently delivered cancer...
Background: Therapeutic interventions such as synthetic drugs and microRNA (miR) modulators have created opportunities for mitigating hepatic ischemia/reperfusion injury (HIRI) by alleviating mitochondrial dysfunction.However, delivering multi-therapeutic ingredients with low toxicity to hepatocytes still lags behind its development.Methods: In this study, we endowed exosomes delivery function concentrate on multidimensionally halting mitochondria dysfunction during HIRI.Concretely, were...
Chinese herbal medicine (CHM) might have benefits in patients with non-diabetic chronic kidney disease (CKD), but there is a lack of high-quality evidence, especially CKD4. This study aimed to assess the efficacy and safety Bupi Yishen Formula (BYF) vs. losartan trial was multicenter, double-blind, double-dummy, randomized controlled that carried out from 11-08-2011 07-20-2015. Patients were assigned (1:1) receive either BYF or for 48 weeks. The primary outcome change slope estimated...
The optimal choice of treatment, with hemodialysis (HD) or peritoneal dialysis (PD), for end-stage renal disease (ESRD) patients, is still controversial. Only a few studies comparing HD and PD have been conducted in China, which has the largest number patients world.A retrospective cohort study was on ESRD who began replacement treatment from January 1, 2012 to December 31, 2017 Guangdong Provincial Hospital Chinese Medicine. Propensity scoring match applied balance baseline conditions...
Necroptosis, pro-inflammatory programmed necrosis, has been reported to exert momentous roles in pancreatic cancer (PC). Herein, the objective of this study is construct a necroptosis-related prognostic model for detecting cancer. In study, intersection between genes and differentially expressed (DEGs) ductal adenocarcinoma (PDAC) was obtained based on GeneCards database, GEO database (GSE28735 GSE15471), verified using The Cancer Genome Atlas (TCGA). Next, with Cox LASSO regression...
Abstract Aim Frailty is common and reported to be associated with adverse outcomes in patients chronic diseases Western countries. However, the prevalence of frailty remains unclear individuals kidney disease (CKD) China. We examined factors CKD. Methods This was a cross-sectional analysis 177 adult (mean age 54 ± 15 years, 52% men) CKD from open cohort entitled Physical Evaluation Adverse for Kidney IN Guangdong (PEAKING). at baseline were assessed by FRAIL scale which included five items:...
Background: IgA nephropathy (IgAN) is the most common type of glomerulonephritis in Asia. Its pathogenesis involves higher expression galactose-deficient IgA1 (Gd-IgA1) and dysregulated intestinal mucosal immunity. The objective this study was to explore whether specific gut microbiota associated enzymes affect Gd-IgA1 IgAN. Methods: This carried out shotgun metagenomic sequencing with Illumina on fecal samples collected from 20 IgAN patients (IgAN group) healthy controls (HCs who were...
Background Diabetic kidney disease (DKD) has become the leading cause of failure, causing a significant socioeconomic burden worldwide. The usual care for DKD fails to achieve satisfactory effects in delaying persistent loss renal function. A Chinese herbal medicine, Tangshen Qushi Formula (TQF), showed preliminary clinical benefits with sound safety profile people stage 2-4 DKD. We present protocol an ongoing trial investigating feasibility, efficacy, and TQF compared placebo progressive...
Background: Fungal peritonitis (FP) is a rare but severe complication that can appear in patients receiving peritoneal dialysis (PD). This study aimed to investigate the incidence rate and clinical characteristics of FP, evaluate outcomes between FP bacterial (BP) on PD, especially estimate risk factors for outbreak. Methods: All episodes diagnosed our hospital from January 1, 2011, December 31, 2020, were reviewed this single-center study. cases analyzed compared with BP 1:6 ratio matching...
Chronic kidney disease (CKD) is a global public health problem. Currently, as for advanced CKD populations, medication options limited in angiotensin-converting enzyme inhibitors (ACEi) and angiotensin receptor blockers (ARB), which were partially effective. A Chinese herbal compound, Bupi Yishen formula, has showed renal protective potential experiments retrospective studies. This study will evaluate the efficacy safety of formula (BYF) patients with stage 4. In this double blind, dummy,...
Background: In clinical practice, Chinese herbal medicine (CHM) purportedly has beneficial therapeutic effects for chronic kidney disease (CKD), which include delaying progression and dialysis initiation. However, there is a lack of high-quality evidence-based results to support this. Therefore, this study aimed evaluate the efficacy CHM combined with Western in treatment stage 5 CKD.Methods: This was prospective nonrandomized controlled study. Stage CKD (nondialysis) patients were recruited...
Pyroptosis, a novel pro-inflammatory type of programmed cell death, is involved in the tumorigenesis various cancers. Recent findings have implicated long non-coding RNAs (lncRNAs) serial steps cancer development. However, expression and prognostic signatures pyroptosis-related lncRNAs hepatocellular carcinoma (HCC) remain largely unknown. Therefore, lncRNA model was constructed for HCC. Thirty-four genes were obtained from previous reviews, gene data collected The Cancer Genome Atlas (TCGA)...