A5101547898- Bone health and osteoporosis research
- Bone Metabolism and Diseases
- Diabetes Treatment and Management
- Bone health and treatments
- Pneumonia and Respiratory Infections
- Diabetes Management and Research
- Metabolism, Diabetes, and Cancer
- Medicinal Plant Pharmacodynamics Research
- Antibiotic Use and Resistance
- Biomarkers in Disease Mechanisms
- Bacterial Identification and Susceptibility Testing
- Growth Hormone and Insulin-like Growth Factors
- Medical Research and Treatments
- Antimicrobial Resistance in Staphylococcus
- Respiratory viral infections research
- Cancer-related molecular mechanisms research
- Nosocomial Infections in ICU
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Folate and B Vitamins Research
- Healthcare and Venom Research
- Cancer Cells and Metastasis
- Pain Mechanisms and Treatments
- Diabetes and associated disorders
- Cytokine Signaling Pathways and Interactions
- Pancreatic function and diabetes
Tongji University
2011-2025
Tongji Hospital
2010-2025
The Fifth People’s Hospital of Suzhou
2025
Affiliated Hospital of Taishan Medical University
2023-2024
Shandong First Medical University
2023-2024
Hunan University
2024
Chongqing Medical University
2022-2024
Jinan Infectious Disease Hospital
2011-2021
Jinan University
2020-2021
Southern University of Science and Technology
2020
Abstract Background The role of mitochondrial dynamics, encompassing fission, fusion, and mitophagy, in cancer progression has been extensively studied. However, the specific impact dynamics on hepatocellular carcinoma (HCC) is still under investigation. Methods In this study, dynamic genes were obtained from MitoCarta 3.0 database, gene expression data collected Cancer Genome Atlas (TCGA) database. Based these differentially expressed (DEGs), patients stratified into two clusters....
Abstract Objective This study aimed to investigate the effect of electromagnetic field (EMF) combined with recombinant human parathyroid hormone (rhPTH) on bone mineral density (BMD) and turnover indicators in postmenopausal osteoporosis (PMOP) patients. Methods A total 336 PMOP patients were randomly assigned into three groups: EMF + rhPTH group ( n = 115), rhPTHx 113) 108). The lumbar spine femoral neck BMDs measured before treatment at 6, 12, 18 months after treatment. Blood calcium,...
Surgical debridement and flap-based reconstruction are essential procedures for managing stage 3 4 pressure injuries (PIs). However, the recurrence of PIs after flap is high; moreover, many patients cannot tolerate surgical management. An 81-year-old male presented with (1 each on sacral region heels) that were successfully treated without The patient was bedridden progressive dementia, pneumonia, malnutrition. He could not thorough debridement. A new silicone rubber negative drainage tube...
Ovarian cancer (OvCa) is a leading cause of mortality from gynecologic malignancy due to its disseminated peritoneal metastasis. The tumor microenvironment dominates epithelial-mesenchymal transition (EMT) development and impacts metastasis as well mediates drug resistance. Tumour cell interaction with the collagen I matrix critical in OvCa development. To better understand role underlying mechanisms early stage invasion, we developed three-dimensional (3D) culture model vitro by embedding...
Abstract The effects of three amino acids (proline, glutamine, and glycine) added to the freezing medium Tes‐Tris‐egg yolk (TTE) for cryopreservation cynomolgus monkey ( Macaca fascicularis ) spermatozoa were studied. This is first report on nonhuman primate sperm cryopreservation. addition 5mM proline, 10mM 10 or 20mM glycine each significantly improved post‐thaw motility membrane acrosome integrity compared with control (TTE alone). However, a significant decrease in membrane/acrosome was...
Abstract Background The 10‐g Semmes–Weinstein monofilament and 128‐Hz tuning fork examinations are considered simple effective screening instruments for diabetic peripheral neuropathy. This study investigated the prevalence of neuropathy combining both methods in type 2 outpatients Chinese urban hospitals. Methods Pressure sensation vibration perception were randomly screened using from 12 centres 8 cities a randomized, multicentre epidemiological study. treatment status assessed, relevant...
Background Recombinant human parathyroid hormone (1-34) (rhPTH (1-34)) is the first agent in a unique class of anabolic therapies acting on skeleton. The efficacy and safety long-term administration rhPTH Chinese postmenopausal women had not been evaluated. This study compared clinical with elcatonin for treating osteoporosis 11 urban areas China. Methods A total 453 were enrolled an 18-month, multi-center, randomized, controlled study. They randomized to receive either 20 μg (200 U) daily...
Recent studies have identified postprandial glycemic excursions as risk factors for diabetes complications. This study aimed to compare the effects of nateglinide and acarbose treatments on in Chinese subjects with type 2 diabetes.This was a multicenter, open-label, randomized, active-controlled, parallel-group study. One hundred three antihyperglycemic agent-naive (hemoglobin A1c range, 6.5-9.0%) were prospectively recruited from four hospitals China. The intervention (120 mg times day) or...
Bioengineering a three-dimensional culture model of human lung cancer cells for screening EGFR targeted inhibitors.
Data about real-world effects of combined therapy with sacubitril/valsartan plus dapagliflozin in patients affected by heart failure (HF) reduced ejection fraction (HFrEF) has not been widely reported. In this article, the benefits and respect to improvements cardiac function HFrEF would be investigated.HF prescribed between January 2020 2022 a tertiary teaching hospital were selected using Computerized Patient Record System. Patients divided into two groups according whether they taking...
To explore the antitumor effect of hypoxia-inducible factor-1 α short hairpin RNA (HIF-1 shRNA) delivered by ultrasound targeted microbubble destruction (UTMD) and transcatheter arterial embolization (TAE) on rats with hepatic cancer. After models transplantation hepatoma were established, Wistar randomly divided into 4 groups: Control group, UTMD TAE UTMD+TAE group. Contrast-enhanced (CEUS) was used to monitor tumor size day 14 after four different treatments. Western blotting...
Background: This study aimed to evaluate the characteristics of bone metabolism and fracture risk in type 2 diabetes mellitus (T2DM) patients with distal symmetric polyneuropathy (DSPN). Methods: A total 198 T2DM individuals were recruited from January 2017 December 2020. Patients DSPN evaluated by strict clinical sensory thresholds. Biochemical parameters mineral density (BMD) measured. The BMD, turnover markers, probability compared between two groups, factors related BMD hip 10 years...
Immune checkpoint inhibitors (ICIs) become integral in clinical practice, yet their application cancer therapy is constrained by low overall response rates and the primary resistance of cancers to ICIs. Herein, this study proposes aggregation-induced emission (AIE)-based nanoparticles (NPs) for a more effective synergistic approach combining immunotherapy photodynamic (PDT) achieve higher responses than anti-PD-L1 monotherapy. The TBP@aPD-L1 NPs are constructed functionalizing azide...
The main aim of this study was to evaluate the association between education level and osteoporosis (OP) in general Chinese Men. We conducted a large-scale, community-based, cross-sectional investigate by using self-report questionnaire assess levels. data 1092 men were available for analysis study. Multiple regression models controlling confounding factors include performed explore relationship OP. Positive correlations T-score quantitative bone ultrasound (QUS-T score) reported (β = 0.108,...
Although the efficacy of teneligliptin, a highly selective dipeptidyl peptidase-4 inhibitor, has been amply studied for treatment type 2 diabetes, no clinical trials teneligliptin have carried out in China. We evaluated and safety monotherapy compared with placebo Chinese patients diabetes mellitus inadequately controlled diet exercise.This multicenter, randomized, double-blind, placebo-controlled, parallel-group study, at 42 sites, enrolled glycosylated hemoglobin 7.0 to <10.0% fasting...