A5101972235- Liver Disease Diagnosis and Treatment
- Metabolism, Diabetes, and Cancer
- Adipose Tissue and Metabolism
- Diabetes Treatment and Management
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diet, Metabolism, and Disease
- Pancreatic function and diabetes
- Cancer, Hypoxia, and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Diabetes Management and Research
- Diabetes and associated disorders
- Lipid metabolism and disorders
- Diabetes Management and Education
- Pain Mechanisms and Treatments
- Telomeres, Telomerase, and Senescence
- Cancer, Lipids, and Metabolism
- Regulation of Appetite and Obesity
- Botulinum Toxin and Related Neurological Disorders
- Apelin-related biomedical research
- Diabetic Foot Ulcer Assessment and Management
- Hormonal and reproductive studies
- Cardiovascular Disease and Adiposity
- Peroxisome Proliferator-Activated Receptors
- Hypothalamic control of reproductive hormones
- Ovarian function and disorders
Nanjing Drum Tower Hospital
2011-2023
Huazhong University of Science and Technology
2023
National Clinical Research Center for Digestive Diseases
2023
Nanjing Medical University
2010-2021
Eli Lilly (United States)
2021
Nanjing University
2013-2018
To compare the effects of gliclazide, liraglutide and metformin on body composition in patients with type 2 diabetes mellitus non-alcoholic fatty liver disease.A total 85 were randomly allocated to receive gliclazide (n = 27), 29) or monotherapy for 24 weeks. Body was measured using dual-energy X-ray absorptiometry.Liraglutide reduced total, trunk, limb, android gynoid fat mass; this also led weight reduction. However, treatment produced no significant changes mass, likely because reductions...
Abstract Apelin is a peptide hormone with anti-oxidative and anti-inflammatory activities proposed to be potential therapeutic for many disease conditions, including sepsis. However, short in vivo half-life of the apelin would limit its clinical applications. This study aims investigate effects Fc-apelin, novel long-acting fusion protein, on lipopolysaccharide (LPS)-induced liver injury. Liver injury was induced by systemic injection LPS mice. Hepatoprotective Fc-apelin against inflammation...
Chiglitazar (Carfloglitazar) is a novel peroxisome proliferator-activated receptor (PPAR) pan-agonist that has shown promising effects on glycemic control and lipid regulation in patients with type 2 diabetes. In this randomized phase 3 trial, we compared the efficacy safety of chiglitazar sitagliptin diabetes who had insufficient despite strict diet exercise regimen. Eligible were (1:1:1) to receive 32 mg (n = 245), 48 246), or 100 248) once daily for 24 weeks. The primary endpoint was...
Abstract Background The 10‐g Semmes–Weinstein monofilament and 128‐Hz tuning fork examinations are considered simple effective screening instruments for diabetic peripheral neuropathy. This study investigated the prevalence of neuropathy combining both methods in type 2 outpatients Chinese urban hospitals. Methods Pressure sensation vibration perception were randomly screened using from 12 centres 8 cities a randomized, multicentre epidemiological study. treatment status assessed, relevant...
AMP-activated protein kinase (AMPK) is an important effector of metformin action on glucose uptake in skeletal muscle cells. We recently reported that improved insulin receptor substrate-1 (IRS-1)-associated signaling by downregulating sterol regulatory element-binding protein‑1c (SREBP-1c) expression. In this study, we investigated whether AMPK activation and SREBP-1c inhibition contribute to the beneficial effects IRS-1-associated L6 myotubes. cells were incubated with palmitic acid (PA)...
Type 2 diabetes mellitus is frequently accompanied by fatty liver disease. Lipid accumulation within the considered as one of risk factors for insulin resistance. Hepatocyte growth factor (HGF) used to treat dysfunction; however, effect and mechanism HGF on hepatic lipid metabolism are still not fully understood.Male C57BL/6 mice were induced with a high-fat diet 12 weeks, followed 4-week treatment or vehicle saline. The levels fasting blood glucose, homeostatic model assessment resistance...
Our aim was to provide a quantitative analysis of the changes in principal determinants insulin sensitivity and secretion relation fasting plasma glucose (FPG) or 2-h (2h PG) Chinese population with wide range tolerance.A total 5728 adults spanning entire tolerance were included. Insulin measured by Matsuda index (ISI(M)) homeostasis model assessment 1/homeostasis resistance (HOMA-IR). β-Cell function adjusted assessed from disposition (DI) at early-phase DI(30) DI(120). The exponential...
Adipokines omentin-1 and adiponectin have been reported to improve insulin resistance. It is known that sensitizers exenatide, avandamet, or diet change from high-fat normal chow ameliorate metabolic disorders. However, whether these treatments increase levels in high fat-diet animals the relationship between remain largely unknown. We investigated effect of exenatide dietary on adipokine levels, body weight, sensitivity diet-induced obese rats. Obesity was induced rats by feeding for 8...
Gonadotropin therapy using a human chorionic gonadotropin (hCG) and FSH preparation is an effective regimen in inducing masculinization spermatogenesis men with idiopathic hypogonadotropic hypogonadism (IHH). However, the high cost of medication frequent injections affect compliance.The aim this study was to determine efficacy sequential use highly purified urinary (uFSH)/hCG IHH.A randomized, open-label, prospective, controlled noninferiority trial 18-month follow-up conducted 9 tertiary...
Previous national survey suggested that dyslipidemia is an increasing burden in China and more severe urban population. In this study, we retrospectively analyzed the gender age differences lipids lipoproteins a large Chinese population Nanjing city.A total of 236, 945 adults (age ≥20 years old) who undertook health check between 2009 2015 our medical examination center were involved analysis. Fasting cholesterol, high-density lipoprotein (HDL) low-density (LDL) cholesterol triglyceride (TG)...
To investigate the prevalence and risk factors of metabolic syndrome (MetS) in Chinese type 2 diabetes mellitus patients, assess effect MetS on treatment patterns blood glucose, pressure lipids goal achievements.Data from 25,454 patients including demographic data, anthropometric measurements, patterns, glucose lipid profiles were retrospectively analyzed.Using modified Adult Treatment Panel III criteria, was 57.4% patients. Multivariable logistic regression analysis showed that who also...
Diabetes management in primary care remains suboptimal China, despite its inclusion the essential public health service (EPHS). We aimed to evaluate effectiveness of a mobile (mHealth) based and three-tiered diabetes system diverse Chinese contexts.This is cluster randomised controlled trial, named road hierarchical at (ROADMAP). 19 008 patients with type 2 (T2D) were recruited from clinics 864 communities across 144 counties/districts 24 provinces. Eligible participants adult diagnosed T2D...
Objective To determine whether super-activation of PPARγ can reprogram human myoblasts into brown-like adipocytes and to establish a new cell model for browning research. Methods enhance the signaling, M3, transactivation domain MyoD, was fused PPARγ. M3-PPARγ-lentiviral vectors were used convert adipocytes. Brown adipocyte markers reprogrammed assessed by qPCR protein analyses. White differentiated from subcutaneous stromal vascular cells perithyroid brown fat tissues as references. Results...
A multicenter, open-label, randomized, controlled superiority trial with 18 months of follow-up was conducted to investigate whether oral zinc supplementation could further promote spermatogenesis in males isolated hypogonadotropic hypogonadism (IHH) receiving sequential purified urinary follicular-stimulating hormone/human chorionic gonadotropin (uFSH/hCG) replacement. Sixty-seven Chinese male IHH patients were recruited from the Departments Endocrinology eight tertiary hospitals and...
Evidence from clinical studies and basic research has shown a strong correlation between Alzheimer's disease (AD) type 2 diabetes. Tau, neuronal microtubule-associated protein, is hyperphosphorylated aggregated into neurofibrillary tangles in the AD brain. However, expression of tau pancreas under debate.We determined mouse pancreas.We used western blots, immunoprecipitation, immunohistochemical staining to analyze pancreatic mice.We found that neither total nor phosphorylated was detectable...