A5100436815- Hepatocellular Carcinoma Treatment and Prognosis
- Pancreatic function and diabetes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatic and Hepatic Oncology Research
- Cancer Mechanisms and Therapy
- Cancer, Lipids, and Metabolism
- Diabetes Treatment and Management
- Genetic factors in colorectal cancer
- Trace Elements in Health
- Liver Disease Diagnosis and Treatment
- Pancreatitis Pathology and Treatment
- Lung Cancer Research Studies
- Ferroptosis and cancer prognosis
- Gout, Hyperuricemia, Uric Acid
- Apelin-related biomedical research
- Aldose Reductase and Taurine
- Hormonal and reproductive studies
- Inflammasome and immune disorders
- Endoplasmic Reticulum Stress and Disease
- Cancer Immunotherapy and Biomarkers
- Renal cell carcinoma treatment
- Nerve injury and regeneration
- Cannabis and Cannabinoid Research
- Curcumin's Biomedical Applications
- Heavy Metal Exposure and Toxicity
Aerospace Center Hospital
2024
Wake Forest University
2024
Guangxi Medical University
2014-2023
Guangxi Center for Disease Prevention and Control
2023
Jiangsu Province Hospital
2023
Nanjing Medical University
2023
Nanchang University
2022
Tumor Hospital of Guangxi Medical University
2022
West China Hospital of Sichuan University
2020
Sichuan University
2020
AimsVildagliptin promotes beta cell survival by inhibiting apoptosis. It has been suggested that chronic ER (endoplasmic reticulum) stress triggers The objective of the study is to explore whether pro-survival effect vildagliptin associated with attenuation endoplasmic reticulum in islets db/db mice.MethodsVildagliptin was orally administered mice for 6 weeks, followed evaluation apoptosis caspase3 activity and TUNEL staining method. Endoplasmic markers were determined quantitative RT-PCR,...
Abstract Purpose Stereotactic body radiotherapy (SBRT) may have significant immunomodulatory effects that enhance tumor response to immune checkpoint inhibitors. This phase 2 clinical trial was conducted evaluate the safety and efficacy of combining palliative SBRT with camrelizumab (an anti-PD1 monoclonal antibody) in patients unresectable hepatocellular carcinoma (uHCC). Methods Patients uHCC, Child–Pugh A/B liver function, at least one measurable lesion were enrolled between April 2020...
The combination of transcatheter arterial chemoembolization (TACE) plus sorafenib prolonged progression-free survival (PFS) and overall (OS) than or TACE monotherapy for patients with hepatocellular carcinoma (HCC). This study assessed the efficacy safety radiotherapy (RT) monoclonal antibody against programmed cell death 1 (anti-PD1) versus advanced HCC.Patients HCC who treated RT anti-PD1 were enrolled. Objective response rate (ORR), PFS, disease control (DCR) OS calculated to assess...
Gonadotropin therapy using a human chorionic gonadotropin (hCG) and FSH preparation is an effective regimen in inducing masculinization spermatogenesis men with idiopathic hypogonadotropic hypogonadism (IHH). However, the high cost of medication frequent injections affect compliance.The aim this study was to determine efficacy sequential use highly purified urinary (uFSH)/hCG IHH.A randomized, open-label, prospective, controlled noninferiority trial 18-month follow-up conducted 9 tertiary...
Abstract Background The prognosis of hepatocellular carcinoma (HCC) varies considerably among patients with the same disease stage and characteristics, only about two thirds show high levels α-fetoprotein (AFP), a common prognostic indicator for HCC. Here, we assessed whether combination presurgical serum AFP carbohydrate antigen 19-9 (CA19-9) can predict HCC after hepatectomy. Methods clinicopathological characteristics post-hepatectomy outcomes 711 were retrospectively reviewed. classified...
The current study was performed to investigate the effects and potential of irbesartan pretreatment on pancreatic β ‐cell apoptosis in a streptozotocin‐ (STZ‐) induced acute mouse model prediabetes. Twenty‐four male BALB/C mice (18–22 g) were randomly divided into three groups: normal control group (NC, n = 6), STZ (STZ, 8), + (IRB STZ, 10). In IRB group, administered (300 mg/kg per day) by gavage for one week. received (80 intraperitoneal (IP) injection once). NC saline IP Fasting blood...
Abstract Objectives Maintenance of functional beta cell mass is critical for prevention diabetes. The transforming growth factor‐beta ( TGF ‐β) receptor signalling pathway plays an essential role in pancreatic development. However, its involvement control post‐natal has only been recently reported. Materials and methods Here, we studied the ‐β proliferation after 50% partial pancreatectomy PP x), using cell‐specific II TBR 2)‐mutated mice. Results Consistent with previous reports, found that...
Dual-phenotype hepatocellular carcinoma (DPHCC) expresses both hepatocyte and cholangiocyte markers, is characterized by high recurrence low survival rates.The underlying molecular mechanisms of DPHCC pathogenesis are unclear.We performed whole exome sequencing RNA three subtypes HCC (10 DPHCC, 10 CK19-positive HCC, 14 CK19-negative HCC), followed integrated bioinformatics analysis, including somatic mutation signal differential gene expression pathway enrichment analysis.Cox proportional...
Current clinical guidelines recommend systematic antitumour therapy as the primary treatment option for patients with stage IIIb hepatocellular carcinoma (HCC) based on China liver cancer (CNLC) staging criteria. Several different targeted therapeutics have been applied in combination immunotherapeutic regimens to date advanced HCC. The present study was developed evaluate relative safety and efficacy of hepatectomy HCC apatinib camrelizumab CNLC-IIIb goal providing evidence regarding...
Abstract Background and objectives To evaluate the individual combined associations of cytokeratin 19 (CK19) microvascular invasion (MVI) with prognosis patients hepatocellular carcinoma (HCC). Methods Clinicopathological data on 352 HCC who underwent radical resection at our hospital between January 2013 December 2015 were retrospectively analyzed. Patients divided into four groups: CK19(−)/MVI(−), CK19(−)/MVI(+), CK19(+)/MVI(−), CK19(+)/MVI(+). Results Of patients, 154 (43.8%)...
Background: We investigated whether the degree of inflammation and fibrosis in para-carcinoma tissue can predict prognosis patients with non-cirrhotic hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC) after hepatectomy. also explored mechanisms through which might affect prognosis. Methods: Clinicopathological data were retrospectively analyzed from 293 HBV-associated HCC who treated at our institution by curative resection 2012 to 2017. Based on Scheuer score system,...
Abstract Objective: The present study aimed to identify risk factors for overall survival in advanced hepatocellular carcinoma (HCC) patients and establish a scoring system select who would benefit from hepatic resection. Methods: Survival curves were analyzed using the Kaplan–Meier method log-rank test. prognostic was developed training cohort Cox-regression model validated external validation Results: There 401 cohort, 163 cohorts. median all 12 ± 1.07 months, rate of 49.6% at 1 year,...
Abstract Background The limited proliferation capacity of β-cells contributes to insulin insufficiency, which promotes the onset diabetes. secrete multiple beneficial substances, except for insulin; therefore, regeneration mechanism requires further study. Previously, ubiquitin-binding enzyme 2C (UBE2C) was reported be downstream key β-cell transcription factor NKX6.1, but specific function and UBE2C in pancreatic islets remain unknown. Methods We performed islet perfusion,...
In 4 602 subjects for routine check-up,blood uric acid,total cholesterol,triglyceride,high density lipoprotein-cholesterol,and low lipoprotein-cholesterol were determined.Results showed that the overall prevalence of hyperuricemia in Nanning,Guangxi was 19.8％ (28.8％ male,9.4％ female).Blood acid and lipids group higher than those normal group(all P＜0.01).Serum had a positive correlation with total cholesterol,triglyceride,low lipoprotein-cholesterol,but it negatively correlated serum high...
Objective Radiofrequency ablation (RFA) and endoscopic breast conserving surgery (EBCS) has been developed as a potential means for treating tumors with minimal disruption to adjacent soft tissues.The purpose of this study was evaluate the cosmetic outcomes RFA assisted by EBCS on patients early carcinoma (T1 -2 N0-1 M0).Methods Twenty-three biopsy proven invasive ( ≤3 cm in diameter),were treated ultrasound (US)guided percutaneous-RFA local followed sentinel lymph node auxiliary dissection...
Abstract Background: The prognosis of hepatocellular carcinoma (HCC) varies considerably among patients with the same disease stage and characteristics, only about two thirds show high levels α-fetoprotein (AFP), a common prognostic indicator for HCC. Here, we assessed whether combination presurgical serum AFP carbohydrate antigen 19-9 (CA19-9) can predict HCC after hepatectomy. Methods: clinicopathological characteristics post-hepatectomy outcomes 711 were retrospectively reviewed....
Abstract Background: Combined hepatocellular-cholangiocarcinoma (CHC) is a rare subtype of primary liver cancer with histologic features both hepatocellular carcinoma (HCC) andintrahepatic cholangiocarcinoma (ICC). The clinicopathological features，prognoses and histogenesis CHC unknown because its low morbidity. Methods: Twenty six patients CHC, 901 HCC, 40 ICC were included into analysis in this retrospective study. Their characteristics prognosis compared. Results: had HCC ICC. Patients...