A5110411023- Retinal Development and Disorders
- MicroRNA in disease regulation
- Circular RNAs in diseases
- CRISPR and Genetic Engineering
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Cancer-related molecular mechanisms research
- Retinal Diseases and Treatments
- Advanced biosensing and bioanalysis techniques
- Pluripotent Stem Cells Research
- RNA modifications and cancer
- Analytical Chemistry and Chromatography
- Mesenchymal stem cell research
- Microfluidic and Capillary Electrophoresis Applications
- Tissue Engineering and Regenerative Medicine
- Autophagy in Disease and Therapy
- RNA Interference and Gene Delivery
- Ocular Surface and Contact Lens
- Neuroscience and Neural Engineering
- Retinal and Optic Conditions
- Meat and Animal Product Quality
- Cancer Cells and Metastasis
- Inflammasome and immune disorders
- Pharmacological Effects and Assays
- Analytical Methods in Pharmaceuticals
Taipei Veterans General Hospital
2007-2025
National Yang Ming Chiao Tung University
2016-2025
Fujian University of Traditional Chinese Medicine
2025
Guangxi Medical University
2010-2024
Ministry of Agriculture and Rural Affairs
2024
Chinese Academy of Agricultural Sciences
2024
Institute of Food Science and Technology
2024
Shanxi Medical University
2023
Shihezi University
2023
Xinjiang Production and Construction Corps
2023
Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumor. Patients diagnosed with GBM have a poor prognosis, it has been reported that tumor malignancy recurrence are promoted by STAT3 signaling. As resveratrol (RV), polyphenol in grapes, to be potent non-toxic cancer-preventive compound, aim of this study was investigate therapeutic effect molecular mechanisms RV on GBM-derived radioresistant initiating cells (TIC). Firstly, our results showed GBM-CD133(+) TIC...
Glioblastoma multiforme (GBM) is the most lethal type of adult brain cancer and performs outrageous growth resistance regardless adjuvant chemotherapies, eventually contributing to tumor recurrence poor outcomes. Considering common heterogeneity cells, imbalanced regulatory mechanism could be switched on/off contribute drug resistance. Moreover, subpopulation GBM cells was recently discovered share similar phenotypes with neural stem cells. These (CSCs) promote potency initiation. As a...
We compared the characteristics of cases highly pathogenic avian influenza (HPAI) and low (LPAI) A(H7N9) virus infections in China. HPAI case-patients were more likely to have had exposure sick dead poultry rural areas hospitalized earlier than LPAI case-patients.
Lung cancers are the leading cause of cancer-related mortality worldwide, and majority lung non-small cell carcinoma (NSCLC). Overexpressed or activated EGFR has been associated with a poor prognosis in NSCLC. We previously identified circular noncoding RNA, hsa_circ_0000190 (C190), as negative prognostic biomarker cancer. Here, we attempted to dissect mechanistic function C190 test potential therapeutic target was upregulated both NSCLC clinical samples lines. Activation pathway increased...
Abstract Background Tyrosine kinase inhibitors (TKIs) that specifically target mutational points in the EGFR gene have significantly reduced suffering and provided greater relief to patients with lung adenocarcinoma (LUAD). The third-generation EGFR-TKI, Osimertinib, has been successfully employed clinical treatments overcome resistance both original acquired T790M L858R points. Nevertheless, issue of treatment failure response emerged as an insurmountable problem. Methods By employing a...
Epithelial-mesenchymal transition (EMT) of retinal pigment epithelial (RPE) cells is related to the pathogenesis various retinopathies including age-related macular degeneration (AMD). Oxidative stress major factor induce RPE and associated with etiology AMD. Sodium iodate (NaIO3) generates intracellular reactive oxygen species (ROS) widely used establish a model AMD due selective induction degeneration. This study was performed clarify effects multiple NaIO3-stimulated signaling pathways on...
Abstract Background Glioblastoma (GBM) is the most lethal brain tumor characterized by high morbidity and limited treatment options. Tumor malignancy usually associated with epigenetic marks, which coordinate gene expression to ascertain relevant phenotypes. One of such marks m6A modification RNA, whose functional effects are dependent on YTH family reader proteins. Methods results In this study, we investigated five proteins in different GBM microarray datasets from Oncomine database,...
Induced pluripotent stem cells (iPSCs) can be differentiated into mesenchymal (iPSC-MSCs), retinal ganglion (iPSC-RGCs), and pigmental epithelium (iPSC-RPEs) to meet the demand of regeneration medicine. Since production iPSCs iPSC-derived cell lineages generally requires massive time-consuming laboratory work, artificial intelligence (AI)-assisted approach that facilitate classification recognize differentiation degree is critical demand. In this study, we propose multi-slice tensor model, a...
Abstract N6-methyladenosine (m 6 A), one of the most prevalent mRNA modifications in eukaryotes, plays a critical role modulating both biological and pathological processes. However, it is unknown whether mutant p53 neomorphic oncogenic functions exploit dysregulation m A epitranscriptomic networks. Here, we investigate Li-Fraumeni syndrome (LFS)-associated neoplastic transformation driven by iPSC-derived astrocytes, cell-of-origin gliomas. We find that but not wild-type (WT) physically...
Multi-modal large language models (MLLMs) have transformed the landscape of modern healthcare, with automated radiology report generation (RRG) emerging as a cutting-edge application. While 2D MLLM-based RRG has been well established, its utility for 3D medical images remains largely unexplored. In this regard, we curate 3D-BrainCT dataset (18,885 text-scan pairs) and develop BrainGPT, clinically visual instruction-tuned (CVIT) model designed CT RRG. notice that traditional LLM metrics...
<title>Abstract</title> <bold>Background</bold> There is a close relationship between nutritional status and symptom clusters. However, research on the characteristics of clusters in different statuses still limited. The purpose this study was to explore heterogeneity patient categories by using latent class analysis provide direction key guidance for clinical cluster management populations. <bold>Methods</bold> This cross-sectional used convenience sampling recruit colorectal cancer...
AimsVildagliptin promotes beta cell survival by inhibiting apoptosis. It has been suggested that chronic ER (endoplasmic reticulum) stress triggers The objective of the study is to explore whether pro-survival effect vildagliptin associated with attenuation endoplasmic reticulum in islets db/db mice.MethodsVildagliptin was orally administered mice for 6 weeks, followed evaluation apoptosis caspase3 activity and TUNEL staining method. Endoplasmic markers were determined quantitative RT-PCR,...
// Chia-Ming Chang 1, 2 , Mong-Lien Wang 3 Kai-Hsi Lu 4 Yi-Ping Yang Chi-Mou Juang Peng-Hui 2, 5 Ren-Jun Hsu 6, 7 Mu-Hsien Yu 8 and Cheng-Chang 1 School of Medicine, National Yang-Ming University, Taipei, Taiwan Department Obstetrics Gynecology, Taipei Veterans General Hospital, Medical Research, Research Education, Cheng-Hsin China University Taichung, 6 Graduate Institute Life Sciences, Defense Center, Biobank Management Center Tri-Service Correspondence to: Chang, email:...
Fabry disease (FD) is a rare inherited disorder characterized by wide range of systemic symptoms; it particularly associated with cardiovascular and renal problems. Enzyme replacement therapy pharmacological chaperone migalastat are the only approved effective treatment strategies for FD patients. It well documented that alpha-galactosidase A (GLA) enzyme activity deficiency causes globotriaosylceramide (Gb3) accumulation, which plays crucial role in etiology FD. However, detailed mechanisms...
Lung cancer is the leading cause of death from in Taiwan and throughout world. Immunotherapy has revealed promising significant efficacy NSCLC, through immune checkpoint inhibition by blocking programmed cell protein (PD)-1/PD-1 ligand (PD-L1) signaling pathway to restore patients' T-cell immunity. One novel type long, non-coding RNAs, circular RNAs (circRNAs), are endogenous, stable, widely expressed tissues, saliva, blood, urine, exosomes. Our previous results that plasma level...