A5006066765- Head and Neck Cancer Studies
- RNA modifications and cancer
- MicroRNA in disease regulation
- RNA Interference and Gene Delivery
- Cancer Cells and Metastasis
- Cytokine Signaling Pathways and Interactions
- CRISPR and Genetic Engineering
- RNA Research and Splicing
- Pluripotent Stem Cells Research
- Cancer Immunotherapy and Biomarkers
- Cancer Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Temporomandibular Joint Disorders
- Cancer-related molecular mechanisms research
- 3D Printing in Biomedical Research
- Tissue Engineering and Regenerative Medicine
- Advances in Cucurbitaceae Research
- Oral and Maxillofacial Pathology
- Chromosomal and Genetic Variations
- Virus-based gene therapy research
- Mesenchymal stem cell research
- Glycosylation and Glycoproteins Research
- Chromatin Remodeling and Cancer
- Bone Tissue Engineering Materials
- Autophagy in Disease and Therapy
National Yang Ming Chiao Tung University
2016-2025
Taipei Veterans General Hospital
2015-2024
National Taipei University
2015-2022
Taipei Medical University-Shuang Ho Hospital
2017-2020
Taipei Hospital
2007-2020
Tri-Service General Hospital
2020
Taipei Medical University
2017
National Yang Ming University Hospital
2006-2016
National Medical Research Center of Dentistry and Maxillofacial Surgery
2011
Institute of Pharmacology
2010
Aim: Silencing information regulator (SirT1), a NAD-dependent histone deacetylase, is an essential mediator of longevity in normal cells by calorie restriction. SirT1 has many biological functions, including transcription regulation, cell differentiation inhibition, cycle and anti-apoptosis. Resveratrol (RV)-induced activation also improves endothelial dysfunction suppresses vascular inflammation. In this study, we investigated the roles RV-induced under oxidative stress.Methods: mRNA...
Abstract MicroRNA‐200c (miR200c) is emerging as an important regulator of tumourigenicity and cancer metastasis with a strong capacity for inducing epithelial–mesenchymal transitions. However, the role miR200c in head neck squamous cell carcinoma (HNSCC) HNSCC‐associated stem cells (HNSCC‐CSCs) unknown. In this study, expression regional metastatic lymph node HNSCC tissues was significantly decreased, but BMI1 increased compared to parental tumours. Importantly, site‐directed mutagenesis...
Abstract Head and neck squamous cell carcinoma (HNSCC) is a prevalent cancer worldwide. Signal transducers activators of transcription 3 (STAT3) signaling reported to promote tumor malignancy recurrence in HNSCC. Cucurbitacins, triterpenoid derivatives, are strong STAT3 inhibitors with anticancer properties. Recent studies have shown aldehyde dehydrogenase 1 (ALDH1) be marker stem cells (CSC) The aim this study was investigate the therapeutic effect cucurbitacin I HNSCC-derived CSCs. Using...
Lin28, a key factor for cellular reprogramming and generation of induced pluripotent stem cell (iPSC), makes critical contribution to tumorigenicity by suppressing Let-7. However, it is unclear whether Lin28 involved in regulating cancer stem-like cells (CSC), including oral squamous carcinoma (OSCC). In this study, we demonstrate correlation between high levels Lin28B, Oct4, Sox2, percentage CD44(+)ALDH1(+) CSC OSCC. Ectopic Lin28B expression CD44(-)ALDH1(-)/OSCC was sufficient enhance...
Glioblastoma multiforme (GBM) is the most lethal type of adult brain cancer and performs outrageous growth resistance regardless adjuvant chemotherapies, eventually contributing to tumor recurrence poor outcomes. Considering common heterogeneity cells, imbalanced regulatory mechanism could be switched on/off contribute drug resistance. Moreover, subpopulation GBM cells was recently discovered share similar phenotypes with neural stem cells. These (CSCs) promote potency initiation. As a...
Recent studies suggest that ALDH1 is a putative marker for HNSCC-derived cancer stem cells. However, the regulation mechanisms maintain stemness and metastatic capability of HNSCC-ALDH1(+) cells remain unclear. Initially, from HNSCC patient showed properties, high expression Bmi1 Snail. Functionally, tumorigenic properties could be downregulated by knockdown Bmi-1. Overexpression Bmi-1 altered in property ALDH1(-) to ALDH1(+) Furthermore, enhanced radiosensitivity radiation-treated Moreover,...
Periodontal disease may cause considerable destruction of alveolar bone, periodontal ligaments (PDLs) and cementum even lead to progressive oral dysfunction. tissue regeneration is the ultimate goal treatment reconstruct both structures functions. However, regenerative efficiency low, possibly due lack a proper microenvironment. In this study, we applied an injectable thermosensitive chitosan/gelatin/glycerol phosphate hydrogel provide 3D environment for transplanted stem cells enhance cell...
// Hsiao-Yun Chen 1 , Liang-Ting Lin 2, * Mong-Lien Wang Shu-Hsien Lee Ming-Long Tsai Chi-Chang 2 Wei-Hsiu Liu 4 Tzu-Chien 5 Yi-Ping Yang 1, Yi-Yen 8 Yuh-Lih Chang Pin-I Huang 6 Yi-Wei Wen-Liang Lo 7 Shih-Hwa Chiou 3, Ming-Teh 3,8 Institute of Clinical Medicine, National Yang-Ming University, Taipei Veterans General Hospital, Taipei, Taiwan Pharmacology, 3 School Graduate Medical Sciences, Defense Center, Department Neurological Surgery, Research, Cancer Division Oral and Maxillofacial...
Studies have demonstrated that mesenchymal stem-like cells can be isolated from endometrium. However, the potential of endometrial-derived stem to differentiate into insulin-positive and functionally secrete insulin remains undetermined. We endometrial (EMSCs) human tissue six donors. The insulin-secreting function EMSCs was further analyzed in vitro transplanted grafts vivo. successfully endometrium, our results showed expressed high levels stemness genes (Nanog, Oct-4, Nestin). Under...
Mounting evidence links cancers possessing stem-like properties with worse prognosis. Network biology signal processing mechanics was explored here using expression profiles of a panel tumor cells (TSLCs). The were compared to their parental (PTCs) and the human embryonic stem (hESCs), for identification gene chromobox homolog 5, CBX5, as potential target lung cancer. CBX5 found regulate TSLCs predictive cancer investigation facilitated by finding genes based on modeling epistatic signaling...
Glioblastoma Multiforme (GBM) is a lethal primary brain tumor with poor survival lifespan and dismal outcome. Surgical resection of GBM greatly limited due to the biological significance brain, giving rise relapse in patients. Transactive response DNA binding protein-43 (TDP-43) DNA/RNA-binding protein known for causing neurodegenerative diseases through post-translational modification; but little about its involvement cancer development. In this study, we found that nutrient deprivation...
Dysphagia was associated with increased prevalence of aspiration pneumonia (AP) in studies that were criticized for either their small sample size or lack prospective design. Using a considerably larger nationwide, population-based database and long-term cohort design, our study aimed to explore the relationship between dysphagia subsequent development AP.From 2000 2009, we gathered consisting 6979 newly diagnosed cases from Taiwan's National Health Insurance Research Database. For control...