A5070110317- Temporomandibular Joint Disorders
- Osteoarthritis Treatment and Mechanisms
- Oropharyngeal Anatomy and Pathologies
- Rheumatoid Arthritis Research and Therapies
- Cell Adhesion Molecules Research
- Protease and Inhibitor Mechanisms
- Salivary Gland Disorders and Functions
- Dysphagia Assessment and Management
- Mass Spectrometry Techniques and Applications
- Cytomegalovirus and herpesvirus research
- Gut microbiota and health
- Nuclear Physics and Applications
- Metabolomics and Mass Spectrometry Studies
- Systemic Lupus Erythematosus Research
- Botulinum Toxin and Related Neurological Disorders
- Musculoskeletal synovial abnormalities and treatments
- Oral and Maxillofacial Pathology
- Tracheal and airway disorders
- Voice and Speech Disorders
- Esophageal and GI Pathology
- Glycosylation and Glycoproteins Research
- Bone Tumor Diagnosis and Treatments
- Oral Health Pathology and Treatment
- Facial Nerve Paralysis Treatment and Research
Tohoku University
2021-2024
National Yang Ming Chiao Tung University
2016-2024
National Taipei University
2017-2019
National Yang Ming University Hospital
2016-2019
Dysphagia was associated with increased prevalence of aspiration pneumonia (AP) in studies that were criticized for either their small sample size or lack prospective design. Using a considerably larger nationwide, population-based database and long-term cohort design, our study aimed to explore the relationship between dysphagia subsequent development AP.From 2000 2009, we gathered consisting 6979 newly diagnosed cases from Taiwan's National Health Insurance Research Database. For control...
The pathogenesis of rheumatoid arthritis (RA)-related temporomandibular joint (TMJ) disorder remains unclear. Studies have reported the change TMJ after complete Freund's adjuvant (CFA) injection, which is consistent with osteoarthritis. However, few studies that tissue response in collagen-induced (CIA) can mimic RA. present study was aimed to investigate rat models by CFA-induced and CIA verify proper RA-related model.In total, 24 rats were randomly divided into four groups: (1) control...
Healthy states of human microbiota depend on a stable community symbiotic microbes irrespective external challenges from the environment. Thus, long-term stability oral is importance, particularly for older patient populations. We used next-generation sequencing (NGS) to examine tongue 18 individuals receiving care over 10-month period. Beta diversity analysis demonstrated temporal microbiota, as microbial compositions all time points were indistinguishable each other (P = 0.0887). However,...
Temporomandibular joint (TMJ) arthritis causes inflammation and degradation of the mandibular condylar cartilage subchondral bone. Complete Freund's adjuvant (CFA) collagen-induced (CIA) are models for studying TMJ arthritis. While micro-computed tomography (micro-CT) is crucial three-dimensional (3D) bone analysis, it has limitations in imaging nonmineralized tissues. Phosphotungstic acid (PTA) enhances soft tissue contrast. However, research on 3D molecular mechanisms CFA- CIA-induced...
Aging, an inevitable physiological process, leads to morphological and histological degenerative changes in the mandibular condylar cartilage (MCC); however, molecular mechanism has not yet been elucidated, little information is available on age-related factors. Therefore, this study was designed identify factors by investigating differentially expressed genes (DEGs) localization of their translated protein expression condyle.Mandibular condyles were collected from 10- 50-week-old mice....
To elucidate the role of Link N in regulating inflammatory molecules from human mesenchymal stem cells (hMSCs) under interleukin (IL)-1β stimulation vitro and Complete Freund's Adjuvant (CFA)-induced arthritis temporomandibular joint (TMJ) vivo.In analysis cytokines epithelial-mesenchymal transition (EMT) genes hMSCs treated with N, IL-1β, co-stimulation IL-1β was undertaken using Luminex multiplex assays real-time polymerase chain reaction, respectively. determine impact ameliorating TMJ...
Mice devoid of matrix metalloproteinase (MMP)-2 due to gene targeting have been reported show articular cartilage destruction in the knee joint; however, phenotype mandibular condylar remains unknown. Thus, present study, we investigated condyle Mmp2-/- mice. We obtained and bred mice from same source as previous performed genotyping using genomic DNA extracted finger snips. The wild-type (WT) was immunohistochemically examined for localization extracellular (ECM) proteins (type I II...
To compare the feasibility and accuracy of three injection techniques for entering superior joint space swine temporomandibular (TMJ).Nine were used this study, in which 500 μL colored dye was injected into both TMJs each swine. Three used: posterior (PI), anterosuperior (ASI), lateral (LI) techniques. Each technique performed on six TMJs. Swine sacrificed immediately after head dissected order to observe distribution. Injection considered successful if no could be observed outside space.The...
Matrix-assisted laser desorption/ionization imaging mass spectrometry (IMS) is used to comprehensively visualize the spatial distribution of numerous biomolecules. The present study was designed investigate phospholipids in developing rat teeth by IMS identify characteristic phospholipid molecules for tooth development, and evaluate suitability tissue preparation methods. Rats at postnatal day 3 were euthanized, resected head specimens either fixed or not with 4% paraformaldehyde (PFA),...