A5003888964- Cancer-related molecular mechanisms research
- Oral Health Pathology and Treatment
- MicroRNA in disease regulation
- Cancer Cells and Metastasis
- Oral and Maxillofacial Pathology
- RNA Research and Splicing
- Hedgehog Signaling Pathway Studies
- RNA Interference and Gene Delivery
- Head and Neck Cancer Studies
- RNA modifications and cancer
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Pluripotent Stem Cells Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Salivary Gland Disorders and Functions
- Wnt/β-catenin signaling in development and cancer
- Phytochemical Studies and Bioactivities
- Oral and gingival health research
- Bone health and treatments
- Facial Rejuvenation and Surgery Techniques
- Periodontal Regeneration and Treatments
- Reconstructive Facial Surgery Techniques
- Skin and Cellular Biology Research
- Cancer-related Molecular Pathways
- Photodynamic Therapy Research Studies
- Cancer Genomics and Diagnostics
Taipei Medical University
2018-2021
Wan Fang Hospital
2018-2021
Luodong Poh-Ai Hospital
2021
Taipei Municipal YangMing Hospital
2017
Taipei Medical University Hospital
2017
Chung Shan Medical University
2011-2017
Chung Shan Medical University Hospital
2011-2014
National Yang Ming Chiao Tung University
2013
Taipei Veterans General Hospital
2012-2013
Abstract Oral squamous cell carcinoma (OSCC) is the most common malignant neoplasm of oral cavity and fourth leading malignancy cause cancer-related death in male population Taiwan. Most cases are detected at advanced stages, resulting poor prognosis. Therefore, improved detection early health disorders indispensable. The involvement bacteria inflammation their association with OSCC progression provide a feasible target for diagnosis. Due to nature neoplasms, diagnosis epithelial precursor...
J Oral Pathol Med (2011) 40: 621–628 Background: squamous cell carcinoma (OSCC) is the sixth most prevalent cancer worldwide. Cancer stem cells (CSC) model theoretically contribute to tumor growth, metastasis, and chemo-radioresistance. Cisplatin a widely used chemotherapeutic agent for OSCC treatment. The aim of this study was compare stemness genes expression in chemo-sensitive chemo-resistant specimens further explore potential markers that may lead induce chemo-resistance OSCC. Methods:...
Abstract ALDH1+CD44+ cells are putative tumor-initiating (TIC) in head and neck squamous cell carcinomas (HNC). miR-145 regulates tumorigenicity various cancers but the breadth of its mechanistic contributions potential therapeutic applications not completely known. Here, we report that ALDH1+CD44+-HNC express reduced levels miR145. SPONGE-mediated inhibition (Spg-miR145) was sufficient to drive characteristics non-TICs/ALDH1−CD44-negative HNC cells. Mechanistic analyses identified SOX9...
Background Overexpression of Oct4, an important transcription factor embryonic stem cells (ESC), has been reported in several cancers. The aim this study was to determine the emerging role Oct4 oral squamous cell carcinoma (OSCC) both vitro and vivo. Methodology/Principal Finding Tumourigenic activity molecular mechanisms overexpression or knockdown by lentiviral infection OSCC investigated Initially, we demonstrated that expression increased lines as compared a normal epithelial line SG....
Increasing evidence indicates that long non-coding RNAs (lncRNAs) regulate diverse cellular processes, such as cell growth, apoptosis and tumorigenesis. However, the functional roles of lncRNAs mechanistic analysis their interplays with oncogenic pathways in oral cancer remain largely unknown. In current study, we examined significance lncRNA HOTAIR (HOX transcript antisense RNA) tumor progression squamous carcinomas (OSCC). We found expression was upregulated tissues, especially metastatic...
Human dental pulp stem cells (DPSCs), unique mesenchymal (MSCs) type, exhibit the characteristics of self-renewal and multi-lineage differentiation capacity. Oct4 Nanog are pluripotent genes. The aim this study was to determine physiological functions expression in DPSCs. Herein, we determined critical role an Oct4/Nanog axis modulating MSCs properties DPSCs by lentiviral-mediated co-overexpression or co-knockdown including osteogenic/chondrogenic/adipogenic induction assayed for markers...
The aim of this research is to synthesize polycaprolactone-based polyurethanes (PCL-based PUs) that can be further used for the fabrication guided bone regeneration (GBR) membranes with higher tensile strength and elongation at break than collagen PTFE membranes. PCL-based PUs were prepared by polymerization polycaprolactone (PCL) diol 1,6-hexamethylene diisocyanate (HDI) different ratios using either polyethylene glycol (PEG) or ethylenediamine (EDA) as chain extenders. chemical,...
Accumulating studies have indicated that long non-coding RNAs (lncRNAs) participate in the regulation of cancer stem cells (CSCs), which are crucial tumor initiation, metastasis, relapse, and therapy resistance. In current study, RT-PCR analysis was employed to evaluate expression LINC00963 tissues oral CSCs. Stemness phenotypes CSCs markers transfected with sh-LINC00963 were examined. Our results showed lncRNA up-regulated We found downregulation inhibited CSC hallmarks, such as migration,...
5-Aminolevulinic acid-mediated photodynamic therapy (ALA-PDT) has been used in the treatment of various precancerous and malignant lesions. Our previous work demonstrated that ALA-PDT possesses potential to serve as an adjuvant against head neck cancer via eliminating stem cells (CSCs) property. This study aimed further investigate possible molecular mechanism underlying effect ALA-PDT. results revealed upregulated expression microRNA-145 (miR-145) two oral cell lines. Overexpression miR-145...
Oral submucous fibrosis (OSF) is an oral precancerous disorder associated with the habit of areca nut chewing. MiR-10b has been shown to be upregulated in cancer cells and induced by Twist. Our previous work revealed that Twist participated pathogenesis OSF therefore we aimed investigate whether Twist/miR-10b axis was involved activation myofibroblast cavity. The expression levels miR-10b tissues fibrotic buccal mucosal fibroblasts (fBMFs) were examined. Besides, determined fBMFs following...
Purpose: Although clinicians encounter patients aged ≥70 years with locally advanced oral cavity squamous cell carcinoma (LA-OCSCC), no evidence is available to facilitate decision making regarding treatment for this elderly population. Methods: We selected (≥70 years) from the Taiwan Cancer Registry database who had received a diagnosis of LA-OCSCC. Propensity score matching was performed. Cox proportional hazards model curves were used analyze all-cause mortality in different age groups...
Oral submucous fibrosis (OSF) has been recognized as a precancerous disorder in the oral cavity. Great effort made to inhibit malignant progression of OSF over past decades, but cure this disease not discovered. In present study, we found that long noncoding RNA, LINC00312, was upregulated tissues, and positively associated with several factors, such α-SMA, type I collagen, fibronectin. As such, sought investigate role LINC00312 identify its interacting factor mediated fibrogenesis. Our...
Various microRNAs (miRs) have been found to be associated with the development of precancerous condition oral cavity, submucous fibrosis (OSF). The expression miR-29c is dysregulated in cancer, but its role OSF has not investigated. purpose study investigate functional and target OSF.The levels tissues fibrotic buccal mucosal fibroblasts (fBMFs) were assessed using next-generation sequencing real-time Polymerase Chain Reaction (PCR) analysis. MiR-29c mimic inhibitors employed examine...
Oral squamous cell carcinoma (OSCC) is a prevalent cancer worldwide. Recent data suggest that subpopulation of cells, termed stem cells (CSCs), capable initiating, maintaining, and expanding the growth tumors. Importantly, CSCs confer chemo- radioresistance. Cisplatin most widely used chemotherapeutic agent, chemoresistance to cisplatin one major causes tumor recurrence metastasis with OSCC. However, role oral-cancer stem-like (OC-SLCs) in OSCC has not determined. The aim this study was...
The habit of areca nut chewing has been regarded as an etiological factor precancerous oral submucous fibrosis (OSF). In the present study, we aimed to evaluate anti-fibrosis effect honokiol, a polyphenolic component derived from Magnolia officinalis. cytotoxicity honokiol was tested using normal and fibrotic buccal mucosal fibroblasts (fBMFs) OSF tissues. Collagen gel contraction, Transwell migration, invasion, wound healing capacities were examined. Besides, expression TGF-β/Smad2...
Oral submucous fibrosis (OSF) has been regarded as a premalignant disorder of oral cancer, and myofibroblasts are the main cells that responsible for pathological fibrosis. Hence, elucidation molecular mechanism underlying myofibroblast activation is important to treat OSF. MicroRNA-21 (miR-21) well-known non-coding RNA, its role in development OSF remains largely unclear.Luciferase reporter assay was used confirm direct interaction between miR-21 target programmed cell death 4 (PDCD4). The...
Betel nut chewing is the major risk factor of oral submucous fibrosis (OSF). Various studies have sought to discover alternative strategies alleviate fibrogenesis. In present study, we aimed evaluate anti-fibrosis effect paeonol, a phenolic component derived from Paeonia Suffruticosa.The cytotoxicity paeonol was tested using normal and fibrotic buccal mucosal fibroblasts (fBMFs) OSF tissues. Collagen gel contraction, Transwell migration, invasion, wound healing capacities were examined....
Oral cancer is one of the common cancers worldwide. Emerging evidence has indicated that microRNAs (non-coding RNA molecules approximately 22 nucleotides in length) are implicated regulation stemness. However, functional role microRNA-509 (miR-509) characteristics oral stem cells (CSCs) not been unraveled. The expression level miR-509 ALDH1+ and sphere CSCs was examined by qRT-PCR. aldehyde dehydrogenase 1 (ALDH1) activity CD44 were assessed using flow cytometry. Self-renewal, transwell...