A5078591592- Lipid metabolism and disorders
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Catalytic Processes in Materials Science
- Hydrogels: synthesis, properties, applications
- Advanced Cellulose Research Studies
- Industrial Gas Emission Control
- Catalysis and Oxidation Reactions
- Caveolin-1 and cellular processes
- Avian ecology and behavior
- Nanoparticle-Based Drug Delivery
- Material Properties and Processing
- Polymer Surface Interaction Studies
- Corrosion Behavior and Inhibition
- Marine Biology and Environmental Chemistry
- Cancer, Lipids, and Metabolism
- Lipoproteins and Cardiovascular Health
- Advanced Drug Delivery Systems
- Lipid metabolism and biosynthesis
- biodegradable polymer synthesis and properties
- RNA Interference and Gene Delivery
- Wildlife Ecology and Conservation
- Electrospun Nanofibers in Biomedical Applications
- Diabetes and associated disorders
- Catalysis and Hydrodesulfurization Studies
- Extraction and Separation Processes
University of South Australia
2013-2020
University College London
2016-2020
Chalmers University of Technology
2001-2018
Great Lakes Institute of Management
2015-2018
University of California, Los Angeles
2015-2017
Umeå University
2012-2015
Weatherford College
2015
Johnson Matthey (Germany)
2015
National Yang Ming Chiao Tung University
2011-2015
Swedish Environmental Protection Agency
2009
Plant mutagenesis is rapidly coming of age in the aftermath recent developments high-resolution molecular and biochemical techniques. By combining high variation mutagenised populations with novel screening methods, traits that are almost impossible to identify by conventional breeding now being developed characterised at level. This paper provides a comprehensive overview various techniques workflows available researchers today field breeding, how these tools complement ones already used...
Inbreeding and loss of genetic diversity are expected to increase the extinction risk small populations, but detailed tests in natural populations scarce. We combine long-term population fitness data with those from two types molecular markers examine role effects a declining metapopulation southern dunlins Calidris alpina schinzii, an endangered shorebird. The decline is associated increased pairings between related individuals, including close inbreeding (as revealed by both field...
Apolipoproteins (apo) C-I and C-III are known to inhibit lipoprotein lipase (LPL) activity, but the molecular mechanisms for this remain obscure. We present evidence that either apoC-I or apoC-III, when bound triglyceride-rich lipoproteins, prevent binding of LPL lipid/water interface. This results in decreased lipolytic activity enzyme. Site-directed mutagenesis revealed hydrophobic amino acid residues centrally located apoC-III molecule critical attachment lipid emulsion particles...
A protein that is expressed on capillary endothelial cells, called GPIHBP1 (glycosylphosphatidylinositol-anchored high-density lipoprotein binding 1), binds lipase and shuttles it to its site of action in the lumen. deficiency prevents from reaching Patients with have low plasma levels lipase, impaired intravascular hydrolysis triglycerides, severe hypertriglyceridemia (chylomicronemia). During characterization a monoclonal antibody-based immunoassay for GPIHBP1, we encountered two samples...
Lipoprotein lipase (LPL) undergoes spontaneous inactivation via global unfolding and this is prevented by GPIHBP1 (Mysling et al., 2016). We now show: (1) that ANGPTL4 inactivates LPL catalyzing the of its hydrolase domain; (2) binding to renders largely refractory inhibition; (3) both LU domain intrinsically disordered acidic are required for protective effect. Genetic studies have found a common polymorphic variant in results lower plasma triglyceride levels. report: less efficient LPL;...
GPIHBP1 is a glycolipid-anchored membrane protein of capillary endothelial cells that binds lipoprotein lipase (LPL) within the interstitial space and shuttles it to lumen. The LPL•GPIHBP1 complex responsible for margination triglyceride-rich lipoproteins along capillaries their lipolytic processing. current work conceptualizes model GPIHBP1•LPL interaction based on biophysical measurements with hydrogen-deuterium exchange/mass spectrometry, surface plasmon resonance, zero-length...
Nano-thin coatings of glutaraldehyde cross-linked polyethyleneimine effectively and selectively accumulated copper from natural seawater.
Ultra-thin PEI-based coatings effectively and selectively accumulated up to 13% copper in the from 200 ppb artificial seawater.
The breeding grounds of the North Atlantic population Sandwich Tern Thalasseus sandvicensis range along coasts western Europe and in Baltic Sea: predominantly Netherlands, UK, France, Germany, Denmark, with a smaller fraction southern Sweden. This has fluctuated strongly size recent decades due to human activities, pollution, changing availability food, outbreaks highly pathogenic avian influenza. To evaluate whether management actions further protect species are needed Sweden, better...
GPIHBP1, a glycosylphosphatidylinositol-anchored glycoprotein of microvascular endothelial cells, binds lipoprotein lipase (LPL) within the interstitial spaces and transports it across cells to capillary lumen. The ability GPIHBP1 bind LPL depends on Ly6 domain, three-fingered structure containing 10 cysteines conserved pattern disulfide bond formation. Here, we report patient with severe hypertriglyceridemia who was homozygous for point mutation that converted serine in domain (Ser-107)...
ApoC-III is often assumed to retard the intravascular processing of triglyceride-rich lipoproteins (TRLs) by inhibiting LPL, but that view based largely on studies free LPL. We now recognize LPL neither nor loosely bound, instead tightly bound glycosylphosphatidylinositol-anchored HDL-binding protein 1 (GPIHBP1) endothelial cells. Here, we revisited effects apoC-III focusing apoC-III'ns capacity affect activity GPIHBP1-bound found TRLs from APOC3 transgenic mice normally cultured cells in...
In mice lacking glycosylphosphatidylinositol-anchored high density lipoprotein binding protein 1 (GPIHBP1), the LPL secreted by adipocytes and myocytes remains bound to heparan sulfate proteoglycans (HSPGs) on all cells within tissues. That observation raises a perplexing issue: Why isn't freshly in wild-type captured same HSPGs, thereby preventing from reaching GPIHBP1 capillaries? We hypothesized that LPL–HSPG interactions are transient, allowing detach move capillaries. Indeed, we found...
Mine waters and tailings generated from mining mineral processing activities often have detrimental impact on the local environment. One example is acid mine drainage, in which sulphides waste react with water oxygen to produce an acidic environment that subsequently dissolves host rock minerals containing toxic metals trace elements. Copper one such metal of significance, as it mined at large volumes sulphide ores. It has strong biocidal activity greatly affects ecosystems. We previously...