A5008407911- MicroRNA in disease regulation
- Glioma Diagnosis and Treatment
- Spinal Fractures and Fixation Techniques
- Spine and Intervertebral Disc Pathology
- Traumatic Brain Injury Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Cancer-related Molecular Pathways
- Injury Epidemiology and Prevention
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Cancer Cells and Metastasis
- Intracerebral and Subarachnoid Hemorrhage Research
- Nerve injury and regeneration
- Meningioma and schwannoma management
- Cardiac Arrest and Resuscitation
- Extracellular vesicles in disease
- Trauma and Emergency Care Studies
- Biochemical effects in animals
- Medicinal Plants and Neuroprotection
- Cerebrospinal fluid and hydrocephalus
- Spinal Cord Injury Research
- Head and Neck Surgical Oncology
- Acute Ischemic Stroke Management
- Chronic Lymphocytic Leukemia Research
- Fungal Biology and Applications
Ministry of Health and Welfare
2016-2025
Taipei Medical University
2015-2024
Taipei Medical University-Shuang Ho Hospital
2015-2024
Jinan City People's Hospital
2016
Shandong First Medical University
2016
Wan Fang Hospital
2007-2015
Zero to Three
2015
University of Fukui
2015
Feng Chia University
2008
The tumor microenvironment (TME) plays a crucial role in virtually every aspect of tumorigenesis glioblastoma multiforme (GBM). A dysfunctional TME promotes drug resistance, disease recurrence, and distant metastasis. Recent evidence indicates that exosomes released by stromal cells within the may promote oncogenic phenotypes via transferring signaling molecules such as cytokines, proteins, microRNAs.In this study, clinical GBM samples were collected analyzed. We found GBM-associated...
Glioblastoma multiforme (GBM) is a highly heterogeneous disease with mesenchymal subtype tending to exhibit more aggressive and multitherapy-resistant features. stem-cells derived from cells are reliant on iron supply, accumulated high reactive oxygen species (ROS), susceptible ferroptosis. Temozolomide (TMZ) treatment the mainstay drug for GBM despite rapid development of resistance in GBM. The main interconnection between features, TMZ resistance, ferroptosis poorly understood. Herein, we...
Objectives: This study's objective was to examine association between sleep duration and quality, metabolic syndrome (MetS) its components in Taiwanese male police officers.Material Methods: Male officers who underwent annual health examinations were invited join the study eventually a total of 796 subjects included it.The divided into 5 groups according length (duration) sleep: < 5, 5-5.9, 6-6.9, 7-7.9 ≥ 8 h per day, global Pittsburgh Sleep Quality Index used categorize their quality as...
Neuroblastoma (NB) is a common neural crest-derived extracranial solid cancer in children. Among all childhood cancers, NB causes devastating loss of young lives as it accounts for 15% mortality. Neuroblastoma, especially high-risk stage 4 with MYCN amplification has limited treatment options and associated poor prognosis. This necessitates the need novel effective therapeutic strategy. JARID1B, also known KDM5B, histone lysine demethylase, identified an oncogene many types. Clinical data...
// Li Wei 1, 2, 3 , Yu-Kai Su Chien-Min Lin 3, 4 Tsu-Yi Chao 5 Shang-Pen Huang 5, 6 Thanh-Tuan Huynh 7 Hsun-Jin Jan 8 Jacqueline Whang-Peng 9 Jeng-Fong Chiou 10, 11 Alexander T.H. Wu 1 Michael Hsiao 12, 13 The Ph.D. Program for Translational Medicine, College of Medical Science and Technology, Taipei University Academia Sinica, Taipei, Taiwan 2 Division Neurosurgery, Department Surgery, Wan Fang Hospital, University, Neurology, School Shuang Ho Graduate Institute Clinical Adventist Center...
Spontaneous intracerebral hemorrhage (ICH) accounts for up to 20% of all strokes and results in 40% mortality at 30 days. Although conservative medical management is still the standard treatment ICH patients with small hematoma, residual hematoma ≤15 mL after surgery are associated better functional outcomes survival rates. This study reported our clinical experience using Robotic Stereotactic Assistance (ROSA) as a safe effective approach stereotactic aspiration intra-clot catheter placement.
The purpose of this study was to compare the effect PbtO 2 -guided therapy with traditional intracranial pressure- (ICP-) guided treatment on management cerebral variables, therapeutic interventions, survival rates, and neurological outcomes moderate severe traumatic brain injury (TBI) patients. From 2009 2010, TBI patients a Glasgow coma scale <12 were recruited from 6 collaborative hospitals in northern Taiwan, excluding systemic injuries, fixed dilated pupils, other major diseases. In...
Objective . This study assessed the posttreatment tumor control and auditory function of vestibular schwannoma (VS) patients after CyberKnife (CK) analyzed possible prognostic factors hearing loss. Methods We retrospectively studied 117 VS patients, with Gardner-Robertson (GR) classification grades I to IV, who underwent CK between 2006 2012. Data including radiosurgery treatment parameters, pre- postoperative size, were collected examined. Results With CK, had excellent rates (99.1%), a...
The present study was carried out to further examine the mechanisms underlying beneficial effects of hyperbaric oxygen (HBO(2)) on experimental spinal cord injury (SCI). Rats were divided into three major groups: (1) sham operation (laminectomy only); (2) laminectomy + SCI normobaric air (NBA; 21% at 1 ATA); and (3) HBO(2) (100% 2.5 ATA for 2 h). Spinal induced by compressing min with an aneurysm clip calibrated a closing pressure 55 g. therapy begun immediately after SCI. Behavioral tests...
OBJECTIVE The use of robotics in spinal surgery has gained popularity because its promising accuracy and safety. ROSA is a commonly used surgical robot system for surgery. aim this study was to compare outcomes between robot-guided freehand fluoroscopy-guided instrumentation minimally invasive (MIS)–transforaminal lumbar interbody fusion (TLIF). METHODS This retrospective consecutive series reviewed 224 patients who underwent MIS-TLIF from March 2019 April 2020 at single institution. All...
OBJECTIVE Both robot and computer navigation have significantly improved the accuracy safety of percutaneous pedicle screw placement compared with a freehand fluoroscopy-guided technique. However, how two new technologies compare each other is unknown. The aim this study was to investigate robot-assisted navigation-guided in minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF). METHODS A multicenter, retrospective conducted patients who underwent 1- 3-level MIS-TLIF from 2019...
Lovastatin, a secondary metabolite isolated from Monascus-fermented red rice mold, has neuroprotective activity and permeates the blood-brain barrier. The aim of this study was to enhance lovastatin for potential use as treatment neuronal degeneration in Parkinson's disease. Six lovastatin-derived compounds were semisynthesized screened neurocytoprotective against 6-hydroxydopamine (6-OHDA)-induced toxicity human neuroblastoma PC12 cells. Four compounds, designated 3a, 3d, 3e, 3f,...
Brain-derived neurotrophic factor (BDNF) is one of the most abundant neurotrophins in adult brain, and it plays important roles modulating synaptic plasticity synaptogenesis. This study attempted to elucidate role BDNF variant rs6265 emotional symptoms following mild traumatic brain injury (mTBI). To investigate association between Val66Met polymorphism (rs6265) mTBI patients, we recruited 192 patients evaluated their Beck Anxiety Inventory (BAI) Depression (BDI) scores first sixth week...
Glioblastoma (GBM), a malignant form of glioma, is characterized by resistance to therapy and poor prognosis. Accumulating evidence shows that the initiation, propagation, recurrence GBM attributable presence stem cells (GBM-CSCs).Herein, we investigated effect 4-Acetylantroquinonol B (4-AAQB), bioactive isolate Antrodia cinnamomea, on cell viability, oncogenic, CSCs-like activities.We observed aberrant expression catenin characteristic GBM, compared other glioma types (p = 0.0001, log-rank...
Abstract Depression is one of the frequent complications following a mild traumatic brain injury (mTBI). Recent research indicated that abnormalities in autonomic nervous system (ANS) can be evaluated by noninvasive power spectral analysis heart rate variability (HRV). In this study, we investigated whether frequency‐domain HRV was correlated with late depression mTBI patients. total, 181 patients diagnosed and 83 volunteers as healthy controls were recruited 2010–2014. Beck Inventory (BDI)...
Abstract Pancreatic cancer represents one of the most aggressive types malignancy due to its high resistance toward clinically available treatments. The presence pancreatic stem‐like cells (CSCs) has been attributed intrinsically and highly metastatic potential this disease. Here, we identified isolated CSCs using side population (SP) method from human cell line, PANC‐1. We then compared SP non‐SP PANC‐1 genetically. exhibited CSC properties including enhanced self‐renewal ability, increased...
Background: Recent studies have shown evidence that higher adiposity in the infrapatellar fat pad (IFP) induces inflammatory phenotypes knee joint and thereby contributes to development progression of osteoarthritis (OA). In particular, IFP adipocyte–derived cytokines participate pathological events. Our previous research has already addressed therapeutic efficacy hyaluronic acid platelet-rich plasma (HA+PRP), including promotion cartilage regeneration inhibition inflammation. The current...
// Yen-Hao Su 1, * , Wen-Chien Huang 2, 3, Tse-Hung 4, 5 Yan-Jiun 6, 11 Yu-Kai Sue 7 Thanh-Tuan Huynh 8 Michael Hsiao 9 Tsan-Zon Liu 10 Alexander TH Wu Chien-Min Lin 7, 12 1 Department of Surgery, Division General Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan 2 Institute Traditional Medicine, School National Yang Ming 3 Thoracic Mackay Memorial 4 Chinese Chang Gung Keelung, Graduate Clinical Medicine Sciences, Taoyuan, 6 University Neurosurgery, University-Shuang Center for...
Glioblastoma (GBM), a malignant grade IV tumor, is the most brain tumor due to its hyper-proliferative and apoptosis-evading characteristics. The signal transducer activators of transcription (STAT) family genes, including STAT3 STAT5A, have been indicated play important roles in GBM progression. Increasing number reports suggest that garcinol, polyisoprenylated benzophenone major bioactive component Garcinia indica contains potent anti-cancer activities.The present study investigated...