- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Cervical and Thoracic Myelopathy
- Musculoskeletal pain and rehabilitation
- Spinal Hematomas and Complications
- Scoliosis diagnosis and treatment
- Medical Imaging and Analysis
- Head and Neck Surgical Oncology
- Meningioma and schwannoma management
- Spinal Cord Injury Research
- Nerve Injury and Rehabilitation
- Traumatic Brain Injury and Neurovascular Disturbances
- Heterotopic Ossification and Related Conditions
- Pituitary Gland Disorders and Treatments
- Nerve injury and regeneration
- Management of metastatic bone disease
- Bone and Joint Diseases
- Pelvic and Acetabular Injuries
- Cardiac, Anesthesia and Surgical Outcomes
- Neurofibromatosis and Schwannoma Cases
- Fungal Biology and Applications
- Fibroblast Growth Factor Research
- Infectious Diseases and Tuberculosis
- Advanced Control Systems Design
- Neurogenesis and neuroplasticity mechanisms
Taipei Veterans General Hospital
2016-2025
National Yang Ming Chiao Tung University
2016-2025
Society for Neuroscience
2024
Taipei Medical University
2024
Institute of Molecular Biology, Academia Sinica
2015-2020
Inari Agriculture (United States)
2020
Institute of Biomedical Sciences, Academia Sinica
2019
Academia Sinica
2015-2018
National Taipei University
2012-2016
The Neurological Institute
2011-2016
Object This study aimed to determine the age- and sex-specific incidence of cervical spondylotic myelopathy (CSM) its associated risk causing subsequent spinal cord injury (SCI). Methods Using National Health Insurance Research Database (NHIRD), a 12-year nationwide database in Taiwan, this retrospective cohort analyzed hospitalization caused by CSM. All patients diagnosed with admitted for CSM were identified during period. The divided into 2 groups, control group an operated group. An...
The long-term outcome of lumbar dynamic stabilization is uncertain. This study aimed to investigate the incidence, risk factors, and outcomes associated with screw loosening in a system.The authors conducted retrospective review medical records, radiological studies, clinical evaluations obtained consecutive patients who underwent 1- or 2-level were followed up for more than 24 months. Loosening screws was determined on radiography CT scanning. Radiographic standardized outcomes, including...
Object The purpose of this study was to provide an evidence-based algorithm for the design, development, and implementation a new checklist response intraoperative neuromonitoring alert during spine surgery. Methods aviation surgical literature surveyed evidence successful implementation. limitations checklists barriers their were reviewed. Based on review, neurosurgical creation developed. Using algorithm, multidisciplinary team best practices how respond alert. All stakeholders then...
Heterotopic ossification (HO) after cervical total disc replacement (TDR) has been reported to impede artificial motion. In all previously cases of HO, assessment was based on plain radiographs. The authors hypothesized that CT scan is a more sensitive and accurate detector. aims this study were assess the actual incidence HO its effect outcome in cohort patients undergoing TDR with Bryan compare detection by means radiographs CT.The retrospectively assessed data from medical records,...
Object The study aimed to verify the safety and feasibility of applying acidic fibroblast growth factor (aFGF) with fibrin glue in combination surgical neurolysis for nonacute spinal cord injury. Methods This open-label, prospective, uncontrolled human clinical trial recruited 60 patients injuries (30 cervical 30 thoracolumbar). mean patient age was 36.5 ± 15.33 (mean SD) years, male/female ratio 3:1. time from injury treatment 25.7 26.58 months, cause included motor vehicle accident (26...
Object Heterotopic ossification (HO) after cervical arthroplasty can limit the mobility of an artificial disc. In this study authors used CT scanning to assess formation HO with goal investigating correlation between carpentry arthroplasty, HO, mobility, and clinical outcomes. Methods A retrospective review medical records, radiological studies, evaluations was conducted for consecutive patients who underwent 1- or 2-level Bryan The follow-up more than 24 months. assessed using as final...
The most currently accepted indication for cervical arthroplasty is 1- or 2-level degenerative disc disease (DDD) refractory to medical treatment. However, the randomized and controlled clinical trials by US FDA investigational device exemption studies only compared with anterior discectomy fusion 1-level disease. Theoretically, spondylosis usually implicates more advanced degeneration, whereas DDD can be caused merely a soft-disc herniation. This study aimed investigate differences between...
Administrative databases are increasingly being used to establish benchmarks for quality of care and compare performance across peer hospitals. As proposals accountable organizations developed, readmission rates will be scrutinized. The purpose the present study was assess whether all-cause readmissions rate appropriately reflects University California, San Francisco (UCSF) Medical Center hospital's clinically relevant spine surgery patients identify predictors readmission.Data 5780...
Object Cervical arthroplasty has been accepted as a viable option for surgical management of cervical spondylosis or degenerative disc disease (DDD). The best candidates are young patients who have radiculopathy caused by herniated with competent facet joints. However, it remains uncertain whether is equally effective myelopathy DDD. aim this study was to compare the outcomes spondylotic (CSM) and without CSM. Methods A total 151 consecutive cases involving CSM DDD underwent one- two-level...
Object Cervical arthroplasty is a valid option for patients with single-level symptomatic cervical disc diseases causing neural tissue compression, but postoperative heterotopic ossification (HO) can limit the mobility of an artificial disc. In present study authors used CT scanning to assess HO formation, and they investigated differences in radiological clinical outcomes either soft-disc herniation or spondylosis who underwent arthroplasty. Methods Medical records, radiographs, evaluations...
Retrospective cohort study.To investigate the differences between single- and multilevel degenerative disc diseases (DDDs) treated with cervical arthroplasty.The US Food Drug Administration clinical trials compared arthroplasty anterior discectomy fusion for single-level DDD. However, DDD is rarely addressed in literature.A total of 102 consecutive patients who underwent Bryan were divided into either a or group. Clinical outcomes measured by visual analogue scale (VAS) neck arm, disability...
Object The goal of the study was to report a series consecutive patients who underwent endoscopic transnasal odontoidectomy (ETO) without resection nasal turbinates. techniques for this minimally invasive approach are described in detail. Methods authors conducted retrospective review ETO basilar invagination. All had myelopathy caused by compression at cervicomedullary junction, which required surgical decompression. Preoperative and postoperative data, including those from radiographic...
OBJECTIVE Many reports have successfully demonstrated that cervical disc arthroplasty (CDA) can preserve range of motion after 1- or 2-level discectomy. However, few studies addressed the extent changes in segmental mobility CDA their clinical correlations. METHODS Data from consecutive patients who underwent 1-level were retrospectively reviewed. Indications for surgery medically intractable degenerative disease and spondylosis. Clinical outcomes, including visual analog scale...
OBJECTIVE This study aimed to estimate the risk of spinal cord injury (SCI) in patients with cervical spondylotic myelopathy (CSM) and without ossification posterior longitudinal ligament (OPLL). Also, compared incidence rates SCI who were managed surgically conservatively. METHODS retrospective cohort covering 15 years analyzed CSM. All patients, identified from National Health Insurance Research Database, hospitalized diagnosis CSM followed up during period. These categorized into 4 groups...
OBJECTIVE Cervical disc arthroplasty (CDA) has been demonstrated to be as safe and effective anterior cervical discectomy fusion (ACDF) in the management of 1- 2-level degenerative disease (DDD). However, there a lack data address fundamental discrepancy between two surgeries (CDA vs ACDF), preservation versus elimination motion, myelopathy associated with congenital stenosis (CCS). Although younger patients tend benefit more from motion preservation, it is uncertain if CCS caused by...
OBJECTIVE Pedicle screw–based dynamic stabilization has been an alternative to conventional lumbar fusion for the surgical management of low-grade spondylolisthesis. However, true effect on adjacent-segment degeneration (ASD) remains undetermined. Authors this study aimed investigate incidence ASD and compare clinical outcomes minimally invasive transforaminal interbody (MI-TLIF). METHODS The records consecutive patients with Meyerding grade I degenerative spondylolisthesis who had undergone...
OBJECT Heterotopic ossification (HO) after cervical arthroplasty is not uncommon and may cause immobility of the disc. To prevent HO formation, study protocols clinical trials for undertaken by US FDA included perioperative use nonsteroidal antiinflammatory drugs (NSAIDs). However, there are few data supporting NSAIDs to arthroplasty. Therefore, this aimed evaluate efficacy in formation outcomes. METHODS Consecutive patients who underwent 1- or 2-level with a minimum follow-up 24 months were...
OBJECTIVE In the past decade, dynamic stabilization has been an emerging option of surgical treatment for lumbar spondylosis. However, application this construct mild spondylolisthesis and its clinical outcomes remain uncertain. This study aimed to compare Dynesys (DDS) with minimally invasive transforaminal interbody fusion (MI-TLIF) management single-level at L4–5. METHODS retrospectively reviewed 91 consecutive patients Meyerding Grade I L4–5 who were managed surgery. Patients divided...
This study aimed to evaluate the effects of Dynesys dynamic stabilization (DDS) on clinical and radiographic outcomes, including spinal pelvic alignment.Consecutive patients who underwent 1- or 2-level DDS for lumbar spondylosis, mild degenerative spondylolisthesis, disc disease were included. Clinical outcomes evaluated by Visual Analogue Scale back leg pain, Oswestry Disability Index, Japanese Orthopedic Association scores. Radiographic assessed radiographs computed tomography. Pelvic...