A5001303129- Neurosurgical Procedures and Complications
- Intracranial Aneurysms: Treatment and Complications
- Intracerebral and Subarachnoid Hemorrhage Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Acute Ischemic Stroke Management
- Cerebrospinal fluid and hydrocephalus
- Full-Duplex Wireless Communications
- Spinal Cord Injury Research
- Characterization and Applications of Magnetic Nanoparticles
- Epilepsy research and treatment
- Heme Oxygenase-1 and Carbon Monoxide
- Cooperative Communication and Network Coding
- Neuroinflammation and Neurodegeneration Mechanisms
- Ocular Surface and Contact Lens
- Neurogenesis and neuroplasticity mechanisms
- melanin and skin pigmentation
- Polyomavirus and related diseases
- Pneumothorax, Barotrauma, Emphysema
- Traumatic Brain Injury Research
- Moyamoya disease diagnosis and treatment
- Neurological Complications and Syndromes
- Congenital Diaphragmatic Hernia Studies
- Vascular Malformations Diagnosis and Treatment
- Innovative Microfluidic and Catalytic Techniques Innovation
- Liquid Crystal Research Advancements
National Taiwan University Hospital
2013-2025
National Taiwan University
2021-2024
Taipei Medical University-Shuang Ho Hospital
2021-2022
Taipei Medical University
2019-2022
Stanford University
2021
Abstract Background External ventricular drains (EVD) are used for acute hydrocephalus in intracranial hemorrhage(ICH), potentially causing ventriculostomy-associated cerebrospinal fluid infection (VAI). Variable meningeal inflammation VAI can result unpredictable antibiotic penetration (CSF). This observational study aimed to assess CSF of intravenous antibiotics suspected treatment neurosurgical patients. Time concentrations and plasma among the The figure presented blood (CSF) measured at...
INTRODUCTION: Polytrauma is a condition that involves multiple injuries affecting different organ systems. Although Body Mass Index (BMI) generally associated with health outcomes across various diseases, the recent concept of “obesity paradox” suggests higher BMI might be protective in certain conditions. However, relationship between and polytrauma-related mortality remains unclear due to conflicting study results. METHODS: A retrospective was conducted on 1234 adult patients critical...
Aneurysmal subarachnoid hemorrhage (SAH) can cause severe neurological deficits and high mortality. Early brain edema following SAH contributes to the initiation of microcirculation impairment may further lead delayed ischemic neurologic deficit (DIND). This study aimed investigate whether dental pulp stem cell conditioned medium (DPSC-CM) ameliorates SAH-induced underlying mechanisms. was induced via intrathecal injection fresh autologous blood in Wistar male adult rat. DPSC-CM or + insulin...
Background Cognitive impairment is common in patients with traumatic brain injury (TBI). Studies that have examined the effectiveness of neurofeedback (NFB) on cognitive function following TBI had poor study designs and small sample sizes. Objectives This randomized controlled trial assessed effects low-resolution tomography Z-score NFB (LZNFB) theta/beta impairment, return to productive activity, quality life TBI. Methods We randomly assigned 87 LZNFB, NFB, or usual care (UC) groups....
Spontaneous intracerebral hemorrhage (ICH) accounts for up to 20% of all strokes and results in 40% mortality at 30 days. Although conservative medical management is still the standard treatment ICH patients with small hematoma, residual hematoma ≤15 mL after surgery are associated better functional outcomes survival rates. This study reported our clinical experience using Robotic Stereotactic Assistance (ROSA) as a safe effective approach stereotactic aspiration intra-clot catheter placement.
A novel device for cholesteric liquid crystal (LC; CLC)-based biosensing chips detecting heme oxygenase (HO)-1 within the cerebrospinal fluid (CSF) was invented. In CLC device, reorientation of LCs strongly influenced by alignment layer surface and adjacent LCs. When substrate coated with layer, CLCs oriented homeotropically in a focal conic state. Once HO-1 immobilized onto orientation sheet-coated substrate, changed from state to bright planar disrupting CLCs. The concentration CSF shown...
Minimally invasive endoscope-assisted (MIE) evacuation of spontaneous intracerebral hemorrhage (ICH) is simple and effective, but the limited working space may hinder meticulous hemostasis might lead to rebleeding. Management intraoperative therefore a critical issue this study. This study presents experience in treatment patients with various types ICH by MIE followed direct local injection FloSeal Hemostatic Matrix (Baxter Healthcare Corp, Fremont, CA, USA) for hemostasis.The retrospective...
We reveal a novel design for dye-doped liquid crystal (DDLC) microfluidic biosensing chips in the polydimethylsiloxane material. With this chip, orientation of DDLCs was affected by interface between walls channels and DDLCs. When inside channel coated with an N,N-dimethyl-n-octadecyl-3-aminopropyltrimethoxysilyl chloride (DMOAP) alignment layer, oriented homeotropically homeotropic (H) state under cross-polarized microscopy. After immobilization antigens antibodies on layer-coated...
Accurate and timely identification of infections is crucial for effective treatment controlling disease spread. While single biomarkers have traditionally served diagnostic purposes, their sensitivity specificity limitations call a more comprehensive approach. Simultaneous detection multiple biomolecules shows promise in improving accuracy, expediting analysis, enhancing pathology screening. Therefore, there pressing need to develop noninvasive biosensor capable quantifying various...
Chronic subdural hematoma (CSDH) is a common neurological disease among elderly adults. The progression of CSDH an angiogenic process, involving inflammatory mediators that affect vascular permeability, microvascular leakage, and thickness. authors aimed to identify biomarkers associated with angiogenesis permeability might influence midline shift
INTRODUCTION: Many studies have revealed that angiogenesis and inflammation are closely linked to the pathophysiology of chronic subdural hematoma (CSDH). The development CSDH is an inflammatory process begins as a local reaction dura meter injury or external stimuli such blood CSF. This causes neovascularization outer membrane vascular hyperpermeability. Heme oxygenase-1 (HO-1) key enzyme catalyzes degradation heme produces biliverdin, ferrous iron, carbon monoxide. HO-1 expression induced...