A5072219208- Dialysis and Renal Disease Management
- Chronic Kidney Disease and Diabetes
- Acute Kidney Injury Research
- Parathyroid Disorders and Treatments
- Renal Diseases and Glomerulopathies
- Central Venous Catheters and Hemodialysis
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Heme Oxygenase-1 and Carbon Monoxide
- Sepsis Diagnosis and Treatment
- Urinary Bladder and Prostate Research
- Trauma and Emergency Care Studies
- Genetic Syndromes and Imprinting
- Renal and Vascular Pathologies
- Electrolyte and hormonal disorders
- Air Quality and Health Impacts
- Heart Failure Treatment and Management
- Blood Pressure and Hypertension Studies
- Lung Cancer Treatments and Mutations
- Renal function and acid-base balance
- Peripheral Artery Disease Management
- Epigenetics and DNA Methylation
- Folate and B Vitamins Research
- Crystallization and Solubility Studies
- Prenatal Screening and Diagnostics
- Neonatal Health and Biochemistry
Taipei Medical University-Shuang Ho Hospital
2015-2024
Ministry of Health and Welfare
2021-2024
Taipei Medical University
2015-2024
National Taiwan University
1997-2024
Jilin University
2024
First Affiliated Hospital of GuangXi Medical University
2024
Guangxi Medical University
2024
Taipei Institute of Pathology
2022
National Taiwan University Hospital
2011-2021
Mackay Memorial Hospital
2021
Traffic emission is responsible for most small-sized particulate matter (PM) air pollution in urban areas. Several recent studies have indicated that traffic-related PM may aggravate kidney disease. Furthermore, exposure to be related the risk of chronic disease (CKD). However, underlying molecular mechanisms not been adequately addressed. In present study, we studied renal damage might associated with PM. a real world whole-body model 3–6 months, ambient can affect function and induce...
Prader-Willi syndrome (PWS) and Angelman (AS) are caused by deficiency of imprinted gene expression from paternal or maternal chromosome 15q11–q13, respectively. Genomic imprinting the PWS/AS domain is regulated through a bipartite cis -acting center (PWS-IC/AS-IC) within upstream SNRPN promoter. Here, we show that two Rb-binding protein-related genes, Rbbp1 / Arid4a Rbbp1l1 Arid4b , involved in regulation IC. We recovered these genes trap mutagenesis selecting for altered an Snrpn -EGFP...
Leukemia evolves through a multistep process from premalignancy to malignancy. Epigenetic alterations, including histone modifications, have been proposed play an important role in tumorigenesis. The involvement of two chromatin remodeling genes, retinoblastoma-binding protein 1 (Rbbp1/Arid4a) and Rbbp1-like (Rbbp1l1/Arid4b), leukemogenesis was not characterized.The leukemic phenotype mice deficient for Arid4a with or without haploinsufficiency Arid4b investigated by serially monitoring...
Abstract PTEN is frequently mutated in prostate cancer. The tumor suppressor function of attributed to its lipid phosphatase activity that counters PI3K action. Here, we report a PTEN-ARID4B-PI3K axis which inhibits expression ARID4B , while transcriptional activator the subunit genes PIK3CA and PIK3R2 are crucial for activation PI3K/AKT pathway. Reciprocal binding histone H1 promoters modulates chromatin condensation, suggesting mechanism by activates these promoters. Functional analyses...
Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs), including gefitinib, are effective for non-small cell lung cancer (NSCLC) patients with EGFR mutations. However, these eventually develop resistance to EGFR-TKI. The goal of the present study was investigate involvement autophagy in gefitinib resistance. We developed gefitinib-resistant cells (PC-9/gef) from PC-9 (containing exon 19 deletion EGFR) after long-term exposure gefitinib. PC-9/gef (B4 and E3) were 200-fold...
Chronic kidney disease (CKD) is highly prevalent in Taiwan. More than two-thirds of end-stage renal associated with diabetes mellitus (DM) or hypertension (HTN). Therefore, the formulation a special preventative policy CKD these patients essential. This study surveyed 14 traditional risk factors and identified their effects on HTN/DM compared general population.This included 5328 cases 5135 controls CKD/HTN/DM outpatient health centres 10 hospitals from 2008 to 2010. Fourteen common effect...
Carbon monoxide (CO) poisoning may cause toxicity of the central nervous system and heart. However, association between CO long-term dementia risk remains unestablished. We investigated incidence in patients with Taiwan evaluated whether they had a higher than did general population.A nationwide population-based cohort study was conducted among identified using Taiwan's National Health Insurance Research Database (NHIRD) during 2004 to 2013. defined according International Classification...
Peritoneal dialysis (PD) is a widely used sustainable kidney replacement therapy. Prolonged use of PD fluids associated with mesothelial-mesenchymal transition, peritoneal fibrosis, and eventual ultrafiltration (UF) failure. However, the impact pressure on peritoneum remains unclear. In present study, we hypothesized increased potential contributing factor to fibrosis investigated possible mechanisms. vitro experiments found that pressurization led mesenchymal phenotype, expression fibrotic...