A5040423746- Parathyroid Disorders and Treatments
- Renal Diseases and Glomerulopathies
- Dialysis and Renal Disease Management
- Chronic Kidney Disease and Diabetes
- Vitamin D Research Studies
- Bone health and treatments
- Circadian rhythm and melatonin
- Pharmacological Effects and Toxicity Studies
- Bone and Joint Diseases
- Eicosanoids and Hypertension Pharmacology
- Acute Kidney Injury Research
- Bone health and osteoporosis research
- Electrolyte and hormonal disorders
- Muscle and Compartmental Disorders
- COVID-19 Clinical Research Studies
- Renal function and acid-base balance
- Vasculitis and related conditions
- Renal and related cancers
- Nitric Oxide and Endothelin Effects
- Systemic Lupus Erythematosus Research
- Heme Oxygenase-1 and Carbon Monoxide
- SARS-CoV-2 and COVID-19 Research
- Bone Metabolism and Diseases
- Immune Response and Inflammation
- Inflammasome and immune disorders
National Defense Medical Center
2015-2024
Tri-Service General Hospital
2015-2024
Fujian Medical University
2023
Kaohsiung Medical University
2013-2022
Kaohsiung Veterans General Hospital
2019
Kaohsiung Medical University Chung-Ho Memorial Hospital
2013-2017
Taipei Medical University-Shuang Ho Hospital
2016-2017
Taipei Medical University
2012-2016
National Yang Ming Chiao Tung University
2014
Institute of Molecular Biology, Academia Sinica
2014
An enhanced formation of nitric oxide (NO) due to induction a calcium-independent (inducible) NO synthase (iNOS) contributes importantly the cardiovascular failure caused by bacterial endotoxin. Repeated challenges with small doses endotoxin result in tolerance both peripheral vascular and death subsequent injection higher dose Here we investigate whether is associated lack iNOS vivo endogenous glucocorticoids play role development tolerance. In anesthetized rats, i.v. administration...
Inflammation, endothelial dysfunction, and mineral bone disease are critical factors contributing to morbidity mortality in hemodialysis (HD) patients. Physical exercise alleviates inflammation increases density. Here, we investigated the effects of intradialytic aerobic cycling on HD Forty end-stage renal patients undergoing were randomly assigned either an or control group. The group performed a program consisting 5-minute warm-up, 20 minutes at desired workload, cool down during 3...
Dental caries arises from an imbalance of metabolic activities in dental biofilms developed primarily by Streptococcus mutans. This study was conducted to isolate potential oral probiotics with antagonistic against S. mutans biofilm formation Lactobacillus salivarius, frequently found human saliva. We analysed 64 L. salivarius strains and that two, K35 K43, significantly inhibited inhibitory more pronounced than those rhamnosus GG (LGG), a prototypical probiotic shows anti-caries activity....
Acute renal failure (ARF) is a life-threatening entity that frequently complicates advanced liver disease. This study documents number of factors may predispose to or precipitate ARF and influence outcomes in patients with Comparisons are also made between subgroups viral alcohol-induced cirrhosis those ARF.We conducted retrospective chart review over one year 127 consecutive hospital admissions 82 who were diagnosed (Child-Pugh Class C) tertiary care center. A diagnosis was 29 another 98...
<h3>Background:</h3> Delayed diagnosis of pyogenic liver abscess remains a challenging problem in the emergency department because associated high morbidity and mortality. <h3>Objective:</h3> To evaluate sensitivity ultrasono-graphy patients presenting to factors that may influence this sensitivity. <h3>Methods:</h3> A retrospective study was conducted diagnosed with (ED) tertiary care teaching hospital for period 5 years. Between May 2001 April 2006, 268 were evaluated by ultrasonography...
Abstract The coupling between DNA methylation and histone modification contributes to aberrant expression of oncogenes or tumor suppressor genes that leads development. Our previous study demonstrated lysine demethylase 2A (KDM2A) functions as an oncogene in breast cancer by promoting stemness angiogenesis via activation the Notch signaling. Here, we demonstrate knockdown KDM2A significantly increases 5′-hydroxymethylcytosine (5′-hmc) level genomic tet-eleven translocation 2 (TET2) various...
Abstract The androgen receptor (AR) has a critical role in promoting androgen-dependent and -independent apoptosis testicular cells. However, the molecular mechanisms that underlie ligand-independent apoptosis, including activity of AR stem cells, are not completely understood. In present study, we generated induced pluripotent cells (iPSCs) from bovine by electroporation octamer-binding transcription factor 4 ( OCT4 ). were supplemented with leukemia inhibitory bone morphogenetic protein 4,...
Background. There is increased oxidative stress in patients undergoing haemodialysis (HD); however, little known of how different dialysis membranes contribute to the induced by procedure per se. We therefore studied influence two on during HD.
Abstract: Idiopathic membranous nephropathy (MN), an autoimmune‐mediated glomerulonephritis, is one of the most common causes nephrotic syndrome in adults. Therapeutic agents for MN remain ill defined. We assessed efficacy melatonin therapy MN. Experimental murine was induced with cationic bovine serum albumin, and mice were immediately administered 20 mg/kg or phosphate‐buffered saline subcutaneously once a day. Disease severity verified by examining urine metabolic profiles renal...
Hemodialysis patients with secondary hyperparathyroidism (SHP) suffer from excessive oxidative stress and inflammation. Vitamin D analogues are currently the first line therapy for SHP, but influence of vitamin treatment on inflammation remains unknown. This study investigated inflammatory markers in hemodialysis SHP. Twenty-five (mean age 58 ± 12 years, 13 males females) were enrolled to receive calcitriol 16 weeks. We evaluated changes serum biochemical parameters, [C-reactive protein...