A5005482884- Viral Infections and Vectors
- Mosquito-borne diseases and control
- Diabetes Treatment and Management
- Pancreatic function and diabetes
- Endoplasmic Reticulum Stress and Disease
- Pancreatitis Pathology and Treatment
- Travel-related health issues
- Metabolism, Diabetes, and Cancer
- Chronic Kidney Disease and Diabetes
- Liver Disease Diagnosis and Treatment
- Colorectal Cancer Screening and Detection
- Adipose Tissue and Metabolism
- Phagocytosis and Immune Regulation
- Health disparities and outcomes
- Alcohol Consumption and Health Effects
- Acute Kidney Injury Research
- Parathyroid Disorders and Treatments
- Renal Diseases and Glomerulopathies
- Epigenetics and DNA Methylation
- Peptidase Inhibition and Analysis
- Adipokines, Inflammation, and Metabolic Diseases
- Malaria Research and Control
- Genetic factors in colorectal cancer
- Cardiac Arrest and Resuscitation
- Gout, Hyperuricemia, Uric Acid
National Defense Medical Center
2016-2025
Hainan General Hospital
2024
Tri-Service General Hospital
2014-2023
Chang Gung University
2023
University of Taipei
2023
Weatherford College
2019-2022
National Science and Technology Council
2020
National Defense Medical College
2019
Kaohsiung Veterans General Hospital
2017
Haikou City People's Hospital
2016
Inflammation, endothelial dysfunction, and mineral bone disease are critical factors contributing to morbidity mortality in hemodialysis (HD) patients. Physical exercise alleviates inflammation increases density. Here, we investigated the effects of intradialytic aerobic cycling on HD Forty end-stage renal patients undergoing were randomly assigned either an or control group. The group performed a program consisting 5-minute warm-up, 20 minutes at desired workload, cool down during 3...
Background Osteoarthritis (OA) is the most common form of arthritis associated with an increased prevalence type 2 diabetes mellitus (T2DM), however their impact on decreasing joint replacement surgery has yet to be elucidated. This study aimed investigate if combination COX-2 inhibitor and metformin therapy in OA T2DM were lower rate than alone. Methods In total, 968 subjects under (case group) between 1 January 31 December 2000 selected from National Health Insurance Research Database...
Abstract Post-stroke depression (PSD) constitutes an important complication of stroke, leading to great disability. After the prevalence rate is about 30%. Depression also affects rehabilitation motivation, delays function recovery, and increases family social burden. The objective this study was explore effect support on in chronic stroke patients relationship between demographic disease characteristics. Total samples were randomly divided into intervention group (n = 31) a control 31)....
Hepatocellular carcinoma (HCC) is a common cancer with poor prognosis and low five-year survival rate. A strong effective CD4+ T cell-mediated cytotoxicity was associated better recurrence rate in HCC, but the regulatory mechanism that controls cell HCC patients not fully examined. Given IL-10-expressing B cells could suppress inflammation of cytotoxic CD8+ cells, helper 1 (Th1) Th17 while promoting (Treg) differentiation, we examined role HBV-related patients. We found compared to healthy...
Background and Objectives: Amebiasis remains an important public health problem worldwide, immigration increased international travel have affected incident disease cases. This study assesses the prevalence of Entamoeba histolytica in Taiwan between 2011 2020 by analyzing data from surveillance programs conducted Centers for Disease Control (TCDC) on laboratory-confirmed Materials Methods: The E. infection-related reported to National Infectious Diseases Statistics System at TCDC 1 January...
We collected data on imported dengue cases between 2011 and 2020 from Taiwan's Centers for Disease Control to determine changes in the case number importation rate of dengue. used open provided by extract confirmed 2020. From 2020, 2883 were reported Taiwan. The was 25.8 46.4 per 100,000 inbound travelers peaking incidence varied sexes, age groups, seasons (P < .001), residence Numerous Indonesia (548 cases), Vietnam (516 Philippines (500). For Taiwan, risk ratio becoming infected 31,712...
Although the World Health Organization (WHO) certified Taiwan as being malaria-free in 1965, there are reports of a few imported cases each year by travelers who visit malaria-endemic areas. This study examined epidemiology malaria from 2014 to 2020, utilizing national surveillance data Centers for Disease Control. Malaria were confirmed through application standard laboratory methods. Passenger came Tourism Bureau, Ministry Transportation and Communication, (TBMTC). All analyzed using SPSS...
Acute influenza-like illnesses (ILIs) are primarily caused by influenza type A or B viruses. Several factors influence the risk of spread ILIs. The present study investigated epidemiological characteristics, differences, and trends viruses, noninfluenza respiratory pathogens, locations where clusters occurred in Taiwan between 2011 2020. analyzed publicly available data on 1,545 confirmed ILI clusters, with obtained from Centers for Disease Control. In total, 1,334 were virus infection, 11...
Background: Advanced glycation end-products (AGEs) can accumulate in organs and tissues during ageing diabetes.Increased levels of AGEs are found the bone tissue patients with osteoporosis.The purpose this study was to evaluate circulating osteoporosis.Methods: We evaluated plasma AGEs, osteoporosis-related biomarkers, mass 82 menopausal women osteoporosis or osteopenia, 16 young 43 healthy without osteopenia.Results: Higher serum were osteopenia group compared (P < 0.0001).A negative...
Patients with diabetes have a relatively high risk of fracture due to osteoporosis. However, the osteoporosis associated use oral hypoglycemic drugs and dipeptidyl peptidase-4 inhibitor (DPP-4i) by patients is unclear. This study aimed explore effect DPP-4i on in Taiwanese type 2 mellitus (T2DM).This enrolled 6339 (DPP-4i group) 25 356 without (non-DPP-4i group). They were matched 1:4 propensity score matching, using confounding variables including sex, age, comorbidities, medication, index...
The etiology of sudden sensorineural hearing loss (SSNHL) remains unclear. Possible causes SSNHL include vascular diseases, viral infection, and autoimmune disorders. Therefore, we investigated whether hepatitis virus infection is correlated with the risk SSNHL. Using data from Taiwan Longitudinal Health Insurance Database, conducted a retrospective matched-cohort study to compare patients diagnosed B or C (HBV/HCV) infections January 1, 2000, December 31, 2010, (N = 170,942)...
Endoplasmic reticulum (ER) stress has emerged as a key player in insulin resistance (IR) progression skeletal muscle. Recent reports revealed that ER stress-induced the expression of protein disulfide isomerase family member 4 (PDIA4), which may be involved IR-related diseases. A previous study showed metformin modulated IR. However, it remained unclear whether alleviated IR by regulating PDIA4 muscle.Herein, we used palmitate-induced C2C12 cells and high-fat diet-induced mouse model to...
Objectives/Hypothesis We investigated incidences of hearing loss among patients with traumatic brain injury (TBI) to evaluate whether they had a higher risk than the general population. Study Design Cohort study. Methods Inpatient data from Taiwan National Health Insurance Research Database January 1, 2000 December 31, 2010 were recorded. Patients TBI and retrospective comparison cohort analyzed. Each subject was individually traced their index date identify subjects who subsequently...
Abstract Increasing evidence supporting a causal link between obesity and endoplasmic reticulum (ER) stress in adipose tissue is being reported. Protein disulfide isomerase 4 (PDIA4) novel ER chaperone involved the pancreatic β‐cells pathogenesis diabetes. However, role of PDIA4 progression remains poorly understood. To assess relationship PDIA4, adiponectin, metformin, we used palmitate‐induced inflammation hypertrophic adipocytes high‐fat diet‐induced mouse model. Our results revealed that...
Patients with diabetes are at increased risk of cancer development and osteoporosis. Metformin is an effective agent for management. Epidemiological studies have identified association between metformin use prevention. This article outlines the potential to attenuate rate osteoporosis in diabetic patients carcinoma situ (CIS). From National Health Insurance Research Database Taiwan, 7827 CIS who were receiving therapy selected, along 23,481 as 1:3 sex-, age- index year-matched controls, not...
Scrub typhus is a zoonotic disease caused by the bacterium Orientia tsutsugamushi. In this study, epidemiological characteristics of scrub in Taiwan, including gender, age, seasonal variation, climate factors, and epidemic trends from 2010 to 2019 were investigated. Information about Taiwan was extracted annual summary data made publicly available on internet Centers for Disease Control. From 2019, there 4352 confirmed domestic 22 imported cases typhus. The incidence ranged 1.39 2.30 per...
Protein disulfide isomerase (PDI) family members are specific endoplasmic reticulum proteins that involved in the pathogenesis of numerous diseases including neurodegenerative diseases, cancer and obesity. However, metabolic effects PDIA4 remain unclear humans. The aims this study were to investigate associations serum with syndrome (MetS) its components Chinese adults.A total 669 adults (399 men 270 women) recruited. Serum concentrations biochemical variables recorded. Insulin sensitivity...
Traits of metabolic syndrome (MetS) and biomarkers inflammation endothelial dysfunction were examined. We investigated the differences various among individuals with or without Mets in a gender-specific manner. The associations between E-selectin MetS further evaluated.A total 205 patients recruited from outpatient clinics Tri-Service General Hospital, Taipei, Taiwan. Inclusion criteria age 20-75 years BMI < 35 kg/m2. Demographic, anthropometric index data compared genders. Markers by...
Morbid obesity is related to chronic inflammation and many metabolic complications. Interleukin (IL)-6 plays a pivotal pathophysiological role in obesity, IL-6 trans-signaling through the soluble receptor (sIL-6R) has major proinflammatory effect. The aim of this study was investigate association between sIL-6R, adipocyte size, insulin resistance morbidly obese individuals.We measured concentrations high-sensitivity C-reactive protein, lipid parameters estimated homeostasis model assessment...
Objectives: The purpose of this study is to evaluate the prevalence and trends cigarette smoking among young military conscripts, officers, university students during recently 10 years in Taiwan. Methods: Repeated cross-sectional surveys were conducted annually conscripts from 2006 2014. All reviewed within 1 month at training center before retiring after year services. officers included using purposive sampling 2004 2008 2013 2014 different Military study. Freshman senior random sampled as...