Shikonin, a major ingredient in the Chinese traditional herb Lithospermum erythrorhixon, exhibits multiple biological functions including antimicrobial, anti-inflammatory, and antitumor effects. In this study, we delineated molecular mechanisms of shikonin apoptosis 143B osteosarcoma cells. Shikonin reduced cell viability cells dose- time-dependent manner. The IC50 at 24 h 48 for was 4.55 2.01μM, respectively. A significantly elicited hypodiploid population found treated with 2, 4, 8μM h....

Background: Advanced glycation end-products (AGEs) can accumulate in organs and tissues during ageing diabetes.Increased levels of AGEs are found the bone tissue patients with osteoporosis.The purpose this study was to evaluate circulating osteoporosis.Methods: We evaluated plasma AGEs, osteoporosis-related biomarkers, mass 82 menopausal women osteoporosis or osteopenia, 16 young 43 healthy without osteopenia.Results: Higher serum were osteopenia group compared (P < 0.0001).A negative...

Impulse oscillometry (IOS) and fractional exhaled nitric oxide (FeNO) are sensitive non-invasive methods to measure airway resistance inflammation, although there limited population-based studies using IOS FeNO predict asthma control.This study aimed investigate the utility of for assessing childhood control in terms small dysfunction inflammation.This prospective observational cohort enrolled 5,018 school children (aged 6-12 years), including 560 asthmatic 140 normal participants. FeNO,...

In the past decade, no significant improvement has been made in chemotherapy for osteosarcoma (OS). To develop improved agents against OS, we screened 70 species of medicinal plants and treated two human OS cell lines with different agent concentrations. We then examined viability using MTT assay. Results showed that a candidate plant, particularly rhizomes Anemone altaica Fisch. ex C. A. Mey aqueous extract (AAE), suppressed HOS U2OS cells concentration-dependent manner. Flow cytometry...

Objectives: Menopausal transition in women initiates with declining estrogen levels and is followed by significant changes their physiological characteristics.These often lead to medical conditions, such as obesity, which correlated chronic low-grade/subclinical inflammation.Ocimum gratissimum L. a food spice or traditional herb many countries; the plant rich antioxidants, possess anti-inflammation activities multitude of other therapeutic functions.Methods: In this study, we evaluated...

Objectives: Menopausal transition with declining estrogen levels significantly affects the physiological properties of women and consequently contributes to a series medical conditions, including obesity.Obesity is crucial risk factor associated cardiovascular diseases, diabetes mellitus, breast cancer.Increasing dietary protein content improves satiety energy expenditure.Thus, we hypothesize that supplementing collagen, common protein, may alleviate menopause-induced obesity.Methods: We...

Background and Objectives: Chronic kidney disease-associated pruritus (CKD-aP) is a common symptom in hemodialysis patients. A frequent intense itching sensation largely torments patients, impacts quality of life outcomes, it has an independent association with mortality. The objective this study to investigate the effects oral supplementation omega-3 polyunsaturated fatty acid (omega-3 PUFA) on circulating interleukin-6 (IL-6), cardiometabolic parameters, skin moisturization, consequent...

The up- and down-regulation of the osteoclastogenesis response depends on estrogen/estrogen receptor (ER) signaling pathway. Previous reports have shown that promoter hypermethylation gene polymorphism ERα are risks for menopausal osteoporosis. No previous study has evaluated expression levels mRNA in osteoporosis using human subjects. We hypothesized may show less resistance to postmenopausal osteoporosis.In this study, we enrolled 107 women older than 45 years without menstruation...

: Fluid restriction commonly causes dry mouth in patients on hemodialysis (HD). The observed effects of chewing gum the amount saliva, interdialytic weight gain (IDWG), and degree thirst HD have been inconsistent. We investigated whether can modulate these three parameters HD.

The objective of this study is to investigate the effects oral supplementation with eicosapentaenoic acid (EPA) on circulating inflammatory factors, cardiometabolic parameters, skin moisturization, and consequent symptoms pruritus depression in maintenance hemodialysis patients.

Background and Objectives: Psoriasis is a chronic, long-term, incurable skin inflammatory disease characterized by the excessive proliferation of epidermal keratinocytes, dilation blood vessels, thickening skin, formation visible red patches variable sizes. The impact on patients differs with severity disease, leading to physiological discomfort psychological distress, which significantly affect quality life. etiology psoriasis not completely clear, but immune cells, including type 1 17...

Background and Objectives: The prevalence of chronic kidney disease (CKD) is approximately 10% the population in many countries. CKD progresses to end-stage renal (ESRD), resulting adverse outcomes, prolonged hospitalization, increased healthcare costs. Therefore, reducing progression ESRD recognized as an important health issue. Materials Methods: Data from study participants with stage 3 5 (n = 7668) were collected National Health Insurance (NHI) program Taiwan (1 November 2014 31 December...

<b>Background</b> Unrecognized or untreated injury in patients with ankylosing spondylitis (AS) may develop anterior column spinal pseudoarthrosis an open wedge bone defect. The methods of surgical treatment are controversial. Combined and posterior stabilizations instrumentation osteoclasis beneficial as shown existing literature review. <b>Case Report</b> A 36-year-old Asian man AS sustained a motor vehicle accident 2 years before presentation. At that time, his immediate magnetic...

Postoperative pain management is an imperative issue for patients undergoing lumbar spinal fusion surgery. Delayed relief associated with poor clinical outcomes. This study compared the effects of intravenously administered patient-controlled analgesia (PCA) intravenous parecoxib, both commonly used methods analgesic control after surgery.A non-randomized was to recruit 68 who were scheduled receive surgery at a hospital in Taiwan from April through December 2020. The group treated parecoxib...

Abstract Background: Cardiovascular diseases are a major cause of death and disability. Research shows that self-management is better than routine care for improving patients’ awareness diseases, self-care, self-efficacy, thereby reducing the recurrence mortality rates cardiovascular diseases. Objectives: This study examined self-control efficacy risk factors in patients with acute coronary syndrome (ACS) before after program. Methods: Purposive sampling was used this quasi-experimental...