A5051304972- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- Drug-Induced Adverse Reactions
- Dermatology and Skin Diseases
- Immune Cell Function and Interaction
- Respiratory and Cough-Related Research
- Food Allergy and Anaphylaxis Research
- T-cell and B-cell Immunology
- Contact Dermatitis and Allergies
- IL-33, ST2, and ILC Pathways
- Systemic Lupus Erythematosus Research
- Urticaria and Related Conditions
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Inhalation and Respiratory Drug Delivery
- Air Quality and Health Impacts
- Pharmacological Effects and Assays
- Psoriasis: Treatment and Pathogenesis
- Blood disorders and treatments
- Immune Response and Inflammation
- Spondyloarthritis Studies and Treatments
- Atherosclerosis and Cardiovascular Diseases
- Liver Diseases and Immunity
- Medicinal Plant Pharmacodynamics Research
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Monoclonal and Polyclonal Antibodies Research
Changhua Christian Hospital
2014-2025
Chung Shan Medical University
2014-2025
Chung Shan Medical University Hospital
2025
Kaohsiung Medical University
2014-2024
National Chung Hsing University
2022-2024
National Yang Ming Chiao Tung University
2009
Chang Jung Christian University
2005
National Defense Medical Center
2001
Tri-Service General Hospital
2001
Chang Gung University
2001
Summary Background Measuring fractional exhaled nitric oxide (FeNO) is a simple and non‐invasive method for assessing airway inflammation. IL‐17 plays an important role in T cell‐dependent inflammatory response that occurs allergic asthma, it could act as potent activator of inducible synthase (iNOS) to amplify FeNO levels. Objectives To evaluate the differences CD4 + IL‐17A cell counts, serum levels, levels children with mild intermittent moderate severe persistent asthma classified by...
Rationale Prolonged exposure to fine particulate matter (PM 2.5 ) may aggravate asthma, impair lung development, and increase airway inflammation. Objective This study investigated the impact of long-term PM on respiratory health, function growth, fractional exhaled nitric oxide (FENO) in a large longitudinal cohort school children. Methods A total 6120 elementary children residing townships near coal-fired power plants Taiwan were prospectively enrolled from 2016 2018. Baseline follow-up...
Long-term peritoneal dialysis (PD) leads to damage and chronic inflammation, resulting in fibrosis (PF). Emerging evidence suggests that yes-associated protein (YAP) is a key player fibrogenesis across various organs. However, its role PD-induced PF remains unclear. We used NIH/3T3 cells, primary mouse fibroblasts, conditional YAP knockout (CKO) mice with glioma-associated oncogene 1 (Gli1)-specific deletion. The effects of knockdown verteporfin, inhibitor, on fibroblast-to-mesenchymal...
Pam3CSK4, a synthetic TLR2 ligand, has been shown to expand CD4+ regulatory T cells (Treg cells). Less is known about the function of CD8+ Treg than generated during allergen-specific immunotherapy (IT). This study investigated whether Dermatophagoides pteronyssinus-specific IT could CD8+CD25+Foxp3+ population and Pam3CSK4 enhance population. PBMCs were isolated from healthy control subjects mite-sensitive asthmatic patients at three specific times: before 6 mo 1 y after maximum-tolerated...
Impulse oscillometry (IOS) and fractional exhaled nitric oxide (FeNO) are sensitive non-invasive methods to measure airway resistance inflammation, although there limited population-based studies using IOS FeNO predict asthma control.This study aimed investigate the utility of for assessing childhood control in terms small dysfunction inflammation.This prospective observational cohort enrolled 5,018 school children (aged 6-12 years), including 560 asthmatic 140 normal participants. FeNO,...
The histone deacetylase (HDAC) inhibitor, which has potential effects on epigenetic modifications, had been reported to attenuate renal fibrosis. CD4+ forkhead box P3 (FOXP3)+ T regulatory (Treg) cells may be converted inflammation-associated helper 17 (Th17) with tissue fibrosis properties. association between FOXP3+IL-17+ and the attenuation of by HDAC inhibitor is not clear.This study evaluated roles Treg their differentiation into Th17 cells, aggravate chronic inflammation in a...
Abstract Background Poor asthma control may adversely affect mental health. Our study investigates the correlation between inadequate control, exhaled nitric oxide (FENO) levels, and anxiety depression among pediatric patients with COVID‐19. Methods This prospective case–control enrolled 520 asthmatic children (8–15 years), including 336 diagnosed COVID‐19 after rapid antigen testing at home 184 age‐matched without infection. FENO spirometry were performed 1 month Scores for Child...
Abstract Background This study aimed to investigate the relationship between CD4 + regulatory T cells (Tregs) and innate lymphoid (ILCs) in children with primary immune thrombocytopenia (ITP) undergoing high‐dose intravenous immunoglobulin (IVIG) therapy. Methods We enrolled a cohort of 30 newly diagnosed ITP healthy controls collected blood samples for levels Tregs, ILCs, relevant cytokines, Treg suppression assay at diagnosis, two days, four weeks, one year (only platelet count) after IVIG...
Nasal nitric oxide (nNO) could be a biomarker for nasal passage inflammation and sinus ostial patency. We have aimed to investigate the nNO concentration effect of antibiotic therapy in children with perennial allergic rhinitis (PAR) with/without acute bacterial sinusitis. enrolled cohort 90 31 PAR, without unilateral maxillary sinusitis, 79 normal children. Acute sinusitis was diagnosed based on clinical signs symptoms, radiographic examination fibroendoscopy. Rhinitis control assessment...
MyD88 is a major toll-like receptor (TLR) adaptor to activate NF-κB, which acts as mater switch for allergic inflammation disease. Sterile hust dust extracts have been reported with TLR-dependent immunostimulatory activities. The aim of this study was evaluate whether Dermatophagoides pteronyssinus (Der p) immunotherapy may increase IL-10+ CD4+ CD25+ T cells modulating signaling proteins, decrease NF-κB expression. Peripheral blood mononuclear were isolated from patients before and after 1...
Hypersensitivity to mosquito bites (HMB) is a rare disease characterized by intense local skin reactions with general symptoms, such as high fever and regional lymphadenopathy after bites. Epstein–Barr virus (EBV) chronic infection NK cell lymphoproliferative have been reported first in diagnosed HMB patients. Here, we present the case of 6-year-old girl 2 months' history bullae necrotic lesions, accompanied temperature, visual hallucinations, liver dysfunction A histopathologic examination...
We focus on the role of CD8+ Treg cell in Intravenous methyl-prednisolone (IVMP) pulse therapy forty patients with active Class III/IV childhood lupus nephritis (LN) heavy proteinuria. IVMP for five days. From peripheral blood mononuclear cells (PBMCs) and renal tissues, we saw definitely restoring both CD4+CD25+FoxP3+ CD8+CD25+Foxp3+ number plus greater expression intracellular IL-10 granzyme B CD8+FoxP3+ from PBMCs. IVMP-treated CD8+CD25+ directly suppressed CD4+ T proliferation induced...
Abstract Background 4‐1BB (CD137), a member of the inducible tumor necrosis factor receptor (TNFR) family, is expressed on regulatory T (Treg) cells and regulates Treg to control allergic inflammation. Pam3CSK4, synthetic TLR2 ligand that can expand CD8 + function, promising adjuvant for allergen immunotherapy (IT). We examined whether Dermatophagoides pteronyssinus (Der p) IT Pam3CSK4 could enhance CD25 CD137 suppressive function decrease nasal nitric oxide (nNO) levels. Methods Nasal...
Allergen‐specific immunotherapy (IT) has been effectively used for the treatment of asthma. Allergen specific IT induced immune tolerance with induction TH 2 cells anergy remain to be clarified. The aim this study was evaluate whether mite allergen Dermatophagoides pteronyssinus (Dpt) serially decreased IL‐4+/CD4+ (TH ) lymphocytes and apoptosis in asthmatic children. Sixty Dpt‐sensitive children were randomly assigned a received an untreated group. treated patients examined at three time...
The issues and challenges in the diagnosis of drug allergy/hypersensitivity among children adults Asia are likely to be different from non-Asian countries.To study diagnostic modalities used evaluation management allergy/drug hypersensitivity reactions (DHRs) member societies Pacific Association Allergy, Asthma Clinical Immunology (APAAACI).A questionnaire comprising 41 questions was circulated electronically individual members APAAACI between January 23, 2020 March 6, 2020.Twenty-six...