A5054899925- Advanced Causal Inference Techniques
- Impact of Technology on Adolescents
- Statistical Methods and Inference
- Orthopaedic implants and arthroplasty
- Orthopedic Infections and Treatments
- Total Knee Arthroplasty Outcomes
- Child Development and Digital Technology
- Health Systems, Economic Evaluations, Quality of Life
- Heart Rate Variability and Autonomic Control
- Diabetes Treatment and Management
- Sleep and Work-Related Fatigue
- Statistical Methods and Bayesian Inference
- Healthcare professionals’ stress and burnout
- Musculoskeletal pain and rehabilitation
- COVID-19 epidemiological studies
- Metabolism, Diabetes, and Cancer
- Statistical Methods in Clinical Trials
- Hepatitis C virus research
- Workplace Health and Well-being
- Digital Marketing and Social Media
- Diabetes Management and Research
- Vitamin D Research Studies
- COVID-19 Clinical Research Studies
- Vitamin C and Antioxidants Research
- Liver Disease Diagnosis and Treatment
National Yang Ming Chiao Tung University
1995-2025
Fujian Agriculture and Forestry University
2025
Linkou Chang Gung Memorial Hospital
2023
Memorial Hospital of South Bend
2015-2023
Chang Gung University
2023
Chang Gung Memorial Hospital
2023
New York University
2020
Fudan University
2018
Columbia University
2016-2017
Harvard University
2013-2017
Global smartphone penetration has led to unprecedented addictive behaviors. The aims of this study are develop diagnostic criteria addiction and examine the discriminative ability validity criteria.We developed twelve candidate for characteristic symptoms four functional impairment caused by excessive use. participants consisted 281 college students. Each participant was systematically assessed smartphone-using behaviors psychiatrist's structured interview. sensitivity, specificity, accuracy...
The aim of this study was to investigate the risk factors smartphone addiction in high school students. A total 880 adolescents were recruited from a vocational Taiwan January 2014 complete set questionnaires, including 10-item Smartphone Addiction Inventory, Chen Internet Scale, and survey content patterns personal use. Of those recruited, 689 students (646 male) aged 14 21 who owned completed questionnaire. Multiple linear regression models used determine variables associated with...
Smartphone addiction is considered a form of technological that has attracted increasing attention.The present study developed and validated the short-form Addiction Inventory (SPAI-SF) established cutoff point for screening smartphone based on diagnostic criteria by psychiatric interview.A total 268 participants completed an online survey collected demographic data, use behaviours, responses to 26-item SPAI.Each participant also interview.Confirmatory factor analysis (CFA) revealed 10-item...
We propose an approach to conduct mediation analysis for survival data with time‐varying exposures, mediators, and confounders. identify certain interventional direct indirect effects through a mediational g‐formula describe the required assumptions. also provide feasible parametric along algorithm software estimate these effects. apply this method analyze Framingham Heart Study investigate causal mechanism of smoking on mortality coronary artery disease. The estimated overall 10‐year...
Abstract To determine whether policies to limit transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) hinder spread other infectious diseases, we analyzed the National Health Insurance database in Taiwan. Rates infections were significantly lower after SARS-CoV-2 prevention measures announced. This finding can be applied cost-effectiveness prevention.
The assessment of direct and indirect effects with time-varying mediators confounders is a common but challenging problem, standard mediation analysis approaches are generally not applicable in this context. mediational g-formula was recently proposed to address paired semiparametric estimation approach evaluate longitudinal empirically. In article, we develop parametric the g-formula, including feasible algorithm implemented freely available SAS macro. Framingham Heart Study data, apply...
Global smartphone penetration has led to unprecedented addictive behaviors. To develop a use/non-use pattern by mobile application (App) in order identify problematic use, total of 79 college students were monitored the App for 1 month. The App-generated parameters included daily frequency, duration and median per epoch. We introduced two other parameters, root mean square successive differences (RMSSD) Similarity Index, explore similarity use non-use between participants. non-use-median...
Oral cancer poses a serious threat worldwide owing to its soaring case-fatality rate and metastatic characteristics of spreading the other parts body. Despite recent breakthroughs in biomedical sciences, detection oral at an early stage is still challenging. Conventional diagnosis clinics optical techniques detect initial stages are quite complicated as well not completely accurate. To enhance survival patients, it important investigate novel methodologies that can provide faster, simpler,...
The few studies that examined the association between residential greenness and birth outcomes have produced inconsistent results, underlying mechanisms of these associations remain unclear. We mediation interaction effects particulate matter (PM) air pollution on relationship exposure during first third trimesters pregnancy outcomes, including preterm (PTB), term low weight (TLBW), small for gestational age (SGA), (BW), head circumference (HC). conducted a retrospective cohort study 16,184...
Pancreatic ductal adenocarcinoma (PDAC) is highly aggressive and has poor prognosis. There are few biomarkers to inform treatment decisions, collecting tumour samples for testing challenging.Circulating cells (CTCs) from patients with PDAC liquid biopsies were expanded ex vivo form CTC-derived organoid cultures, using a laboratory-developed biomimetic cell culture system. organoids tested sensitivity panel of nine drugs, tests conducted in triplicate, weighted cytotoxicity score (CTS) was...
BackgroundChronic periprosthetic joint infection (PJI) presents a major challenge in knee arthroplasty, with varying success rates reported for two-stage exchange arthroplasty (EA) and lack of consensus on managing failures from such procedures. This study evaluated repeat EA outcomes PJI after initial treatment failure to identify the risk factors reimplantation unsuitability reinfection.MethodsWe analyzed 114 patients who underwent chronic between 2010 2018. From an cohort 1,351 patients,...
The standard treatment for periprosthetic joint infections (PJI) typically involves a two-stage resection arthroplasty using antibiotic-loaded bone cement (ALBC) spacers. This study hypothesizes that there is no significant correlation between antibiotic levels in blood and synovial fluid the patient's kidney function, success rates of staged are comparable groups, specifically targeting gram-positive bacterial infections. retrospective review included patients treated from 2017 to 2022 with...
ABSTRACT Summary‐data Mendelian randomization (MR), a widely used approach in causal inference, has recently attracted attention for improving mediation analysis. Two existing methods corresponding to the difference method and product of linear analysis have been developed perform MR‐based using inverse‐variance weighted (MR‐IVW). Despite these developments, there is still need more rigorous, efficient, precise methodologies. In this study, we develop summary‐data frameworks We improve...
Orbitides, also known as Caryophyllaceae-type cyclic peptides, from Traditional Chinese Medicine plant Pseudostellaria heterophylla (Mil.) Pax have great potential for improving memory and treating diabetes. Orbitides are ribosomally encoded post-translationally modified but this key biosynthesis enzyme is still unknown in P. heterophylla. We investigated the orbitide distribution mined novel precursor peptide genes cyclase multiple omics data. The function of tailoring gene was elucidated...
Background Phantom vibration syndrome is a type of hallucination reported among mobile phone users in the general population. Another similar perception, phantom ringing syndrome, has not been previously described medical literature. Methods A prospective longitudinal study 74 interns (46 males, 28 females; mean age, 24.8±1.2 years) was conducted using repeated investigations prevalence and associated factors ringing. The accompanying symptoms anxiety depression were evaluated with Beck...
Background. Gitelman's syndrome (GS), which is caused by homozygous or compound heterozygous mutations of the thiazide-sensitive sodium chloride cotransporter (NCC), usually manifests in children and associated with low blood pressure. However, prevalence NCC their association pressure have not yet been studied. Methods. Five hundred unrelated from Taipei Children Heart Study were enrolled. Genomic DNA was isolated peripheral SLC12A3 gene amplified polymerase chain reaction (PCR). The 15...
Global smartphone expansion has brought about unprecedented addictive behaviors. The current diagnosis of addiction is based solely on information from clinical interview. This study aimed to incorporate application (app)-recorded data into psychiatric criteria for the and examine predictive ability app-recorded addiction.Smartphone use 79 college students were recorded by a newly developed app 1 month between December 1, 2013, May 31, 2014. For each participant, psychiatrists made 2...
Abstract Standard causal mediation analysis decomposes the total effect into a direct and an indirect in settings with only one single mediator. Under multiple mediators, all mediators are often treated as block of mediators. The mediated by certain combination i. e. path-specific (PSE), is not always identifiable without making strong assumptions. In this paper, authors propose method, defining randomly interventional analogue PSE (rPSE), alternative approach for mechanism investigation....
To determine whether physicians with harm avoidance (HA) personality traits were more prone to developing increased anxiety and depression during the medical internship. A prospective longitudinal study of 74 interns was carried out using repeated measures symptoms Beck Anxiety Depression Inventories (BAI BDI) before, at 3rd, 6th, 12th months internship, 2 weeks after internship completed. Baseline assessed by Tridimensional Personality Questionnaire 3 dimensions: novelty-seeking, HA, reward...