A5012200456- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Mesenchymal stem cell research
- Acute Myeloid Leukemia Research
- Head and Neck Cancer Studies
- Colorectal Cancer Treatments and Studies
- RNA modifications and cancer
- Lung Cancer Treatments and Mutations
- Gastric Cancer Management and Outcomes
- Cancer Cells and Metastasis
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Immune cells in cancer
- Cancer Risks and Factors
- Esophageal Cancer Research and Treatment
- Lung Cancer Research Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Colorectal and Anal Carcinomas
- Cancer Treatment and Pharmacology
- Chronic Myeloid Leukemia Treatments
- Colorectal Cancer Surgical Treatments
- Pancreatic and Hepatic Oncology Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Kruppel-like factors research
Taipei Medical University
2017-2024
Taichung Veterans General Hospital
2022-2024
Academia Sinica
2024
National Chung Hsing University
2022-2023
Taipei Medical University Hospital
2017-2022
Chiayi Chang Gung Memorial Hospital
2010-2019
Chang Gung University
2008-2017
Chang Gung University of Science and Technology
2006-2015
Seoul National University Hospital
2015
Chang Gung Memorial Hospital
2008-2013
This study examined whether mesenchymal stem cells (MSCs), which are originated from embryonic mesoderm, able to differentiate into functional hepatocyte–like in vitro . MSCs were isolated human bone marrow and umbilical cord blood, the surface phenotype mesodermal multilineage differentiation potentials of these characterized tested. To effectively induce hepatic differentiation, we designed a novel 2–step protocol with use hepatocyte growth factor oncostatin M. After 4 weeks induction,...
Abstract Using high-density oligonucleotide microarrays and functional network analyses, we examined whether MSCs derived from four different origins exhibited unique gene expression profiles individually then compared the of all with those fetal organs. Our results indicated that within each group same origin, variability levels was smaller than between groups origins. Functional genomic studies revealed specific roles suggest amniotic fluid may initiate interactions uterus by upregulating...
The identification of potential tumor markers can improve therapeutic planning and patient management. aim this study was to highlight the significance IL-6 in esophageal squamous cell carcinoma (SCC). We retrospectively analyzed clinical outcomes 173 patients with SCC, examined correlation between levels cancer patients. Furthermore, human SCC line CE81T selected for cellular animal experiments investigate changes behavior treatment response after manipulation expression. In outcome...
// Miao-Fen Chen 1,2 , Feng-Che Kuan 2,3 Tzu-Chen Yen 4,5 Ming-Shian Lu 6 Paul-Yang Lin 7 Yi-Hsiu Chung 5 Wen-Cheng and Kuan-Der Lee 1 Department of Radiation Oncology, Chang Gung Memorial Hospital at Chiayi, Taiwan 2 University, College Medicine, 3 Hematology 4 Nuclear Medicine Department, Linko, Center for Advanced Molecular Imaging Translation, Hospital, Thoracic & Cardiovascular Surgery, Pathology, Correspondence: email: Keywords : IL-6; esophageal SCC; MDSC Received July 07, 2014...
// Miao-Fen Chen 1, 2 , Ping-Tsung 2, 3 Wen-Cheng Ming-Shian Lu 4 Paul-Yang Lin 5 Kuan-Der Lee 1 Department of Radiation Oncology, Chang Gung Memorial Hospital at Chiayi, Taiwan College Medicine, University, Hematology and Thoracic & Cardiovascular Surgery, Pathology, Correspondence to: Lee, e-mail: leecgmh@gmail.com Keywords: PD-L1, esophageal SCC, IL-6, CD8+ T cell Received: September 30, 2015 Accepted: January 02, 2016 Published: 09,...
Abstract Although DNA hypermethylation within promoter CpG islands is highly correlated with tumorigenesis, it has not been established whether a specific tumor suppressor gene (TSG) sufficient to fully transform somatic stem cell. In this study, we addressed question using novel targeted methylation technique methylate the promoters of HIC1 and RassF1A, two well-established TSGs, along two-component reporter system visualize successful targeting human bone marrow–derived mesenchymal cells...
REACH is the first phase 3 trial to provide information on hepatocellular cancer (HCC) in second-line (postsorafenib) setting categorized by Child-Pugh score, a scoring system used measure severity of chronic liver disease. This exploratory analysis demonstrates relationship between potential ramucirumab survival benefit, disease, and baseline α-fetoprotein (αFP).To assess treatment effects tolerability score patients with HCC enrolled trial.Randomized, double-blind, best supportive care vs...
Endoplasmic reticulum ( ER ) stress is an adaptive response to various conditions and plays emerging roles in cancer. Activating transcription factor 6 ATF 6), one of the three major transducers, has been shown contribute chemoresistance by altering cancer cell survival. Cancerous inhibitor protein phosphatase 2A CIP 2A) oncogene, its expression correlated with prognosis patients In this study, we aimed explore relationship between stress‐related signaling 2A. We found that was positively...
Abstract Studies conducted in Western countries have reported excess risks for second primary malignancies after breast cancer. However, there is little documentation of ethnic differences these risks. Asian women are characterized by younger age at diagnosis cancer, but very few reports available on the incidences and cancers this region. Using population-based data from Taiwan National Cancer Registry (TNCR) period 1979 to 2003, we quantified standardized incidence ratios cumulative among...
Although certain inhibitors of histone deacetylases have been shown to induce cytotoxicity alone or in combination with chemotherapeutic agents cancer cells, the molecular mechanism is not clear. The goal present study was determine whether antiseizure drug valproic acid (2‐propylpentanoic acid; VPA), which also able inhibit deacetylase, exhibits synergistic cisplatin, and possible pathways for this. Our results clearly show that VPA only cisplatin all ovarian carcinoma cells tested, but can...
// Ching-Yuan Wu 1, 2 , Yao-Hsu Yang Yin-Yin Lin 1 Feng-Che Kuan 3 Yu-Shin 4 Wei-Yu 5, 6 Ming-Yen Tsai 7 Jia-Jing Yu-Ching Cheng Li-Hsin Shu Ming-Chu Lu Yun-Ju Chen 8, 9 Kuan-Der Lee and Hong-Yo Kang Department of Chinese Medicine, Chiayi Chang Gung Memorial Hospital, Chiayi, Taiwan School medicine, College University, Tao-Yuan, Hematology oncology, Pharmacy, 5 Urology, Hospital at Puzi City, University Science Technology, Chia-Yi, Hospital-Kaohsiung Medical Center, Kaohsiung, 8 Graduate...
Pancreatic ductal adenocarcinoma (PDAC) is highly aggressive and has poor prognosis. There are few biomarkers to inform treatment decisions, collecting tumour samples for testing challenging.Circulating cells (CTCs) from patients with PDAC liquid biopsies were expanded ex vivo form CTC-derived organoid cultures, using a laboratory-developed biomimetic cell culture system. organoids tested sensitivity panel of nine drugs, tests conducted in triplicate, weighted cytotoxicity score (CTS) was...
Most studies on second primary malignancies (SPMs) after thyroid cancer were conducted in USA or Europe. The discrepancy between SPMs these could be attributed to geographical and ethnic heterogeneity. Thus, there is a clear need for another large-scale epidemiological study, particularly Asian countries, define the incidence risk of survivors.A population-based study was using nation-wide database from Taiwan Cancer Registry 1979 2006.We quantified standardized ratios (SIRs) cumulative...
Changes in DNA methylation are associated with changes somatic cell fate without the alteration of coding sequences. In addition to its use as a traceable biomarker, reversible could also serve therapeutic target. particular, if development drug resistance is methylation, then demethylation might reverse phenotype. The reversion drug-resistance be feasible association between abnormal and identified. Methylation differences cervical cancer cell, SiHa, derived oxaliplatin-resistant S3 cells...
Anthracycline and taxane are classes of drugs that frequently used in the adjuvant palliative settings metastatic breast cancer (MBC); however, treatment failure occurs most cases. Limited data demonstrated favorable response MBC after previous taxane-based treatment. The aim this study was to evaluate efficacy safety pegylated liposomal doxorubicin (Lipo-Dox®) as part a combination salvage therapy for patients with whose tumors progressed during or treatment.Patients who failed respond...