A5044369810- Hemophilia Treatment and Research
- Chronic Myeloid Leukemia Treatments
- Platelet Disorders and Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Blood groups and transfusion
- Heparin-Induced Thrombocytopenia and Thrombosis
- Viral-associated cancers and disorders
- Colorectal Cancer Treatments and Studies
- Hematopoietic Stem Cell Transplantation
- Blood Coagulation and Thrombosis Mechanisms
- Eosinophilic Disorders and Syndromes
- Bone and Joint Diseases
- Hemoglobinopathies and Related Disorders
- Hematological disorders and diagnostics
- Acute Lymphoblastic Leukemia research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Venous Thromboembolism Diagnosis and Management
- Intraperitoneal and Appendiceal Malignancies
- Gastrointestinal Tumor Research and Treatment
- Colorectal Cancer Surgical Treatments
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Pancreatic and Hepatic Oncology Research
National Defense Medical Center
2014-2024
Tri-Service General Hospital
2015-2024
London Rebuilding Society
2015
SwissLitho (Switzerland)
2015
Kaohsiung Medical University Chung-Ho Memorial Hospital
2015
National Health Research Institutes
2015
National Cheng Kung University Hospital
2015
Mayo Clinic in Arizona
2003
The National Comprehensive Cancer Network (NCCN) International Prognostic Index (IPI) is an enhanced prognostic tool that has identified some specific extranodal sites as a poor factor. We retrospectively analyzed 148 Taiwanese patients with newly diagnosed diffuse large B-cell lymphoma receiving rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone (R-CHOP)-like regimens from January 2001 to December 2010 at the Tri-Service General Hospital. In univarate analysis, ≥ 2...
Introduction Intra‐articular platelet‐rich plasma (PRP) injection therapy has been extensively applied in clinical practice to treat musculoskeletal disorders such as osteoarthritis, but the treatment for haemophilic arthropathy is rarely reported. Aims This study aimed compare efficacy of intra‐articular PRP vs hyaluronic acid (HA) injections treating knee joints. Patients Twenty‐two haemophilia patients (mean age, 41.1 ± 1.7 [range, 20‐50] years) with painful were enrolled this open‐label...
Regular prophylaxis with exogenous factor VIII (FVIII) is recommended for individuals severe haemophilia A (HA), but standardised data are scarce. Here, we report real-world from a global cohort. Participants were men ≥18 years old HA (FVIII ≤ 1 IU/dL) receiving regular FVIII. provided 6 months of retrospective and prospectively followed up to 12 months. Annualised bleeding rate (ABR) FVIII utilisation infusion rates calculated. Differences between geographic regions explored. Of 294...
Abstract Chronic myeloid leukemia (CML) is a myeloproliferative disorder associated with the Philadelphia chromosome, and current standard of care use tyrosine kinase inhibitors (TKI). However, some patients will not achieve molecular response may progress to blast crisis, underlying mechanisms remain be clarified. In this study, next-generation sequencing was used explore endogenous miRNAs in CML versus healthy volunteers, miR-342-5p identified as primary target. We found that downregulated...
Although shoulder problems frequently occur in patients with hemophilia, systematic evaluation of joint damage these has only rarely been reported.The clinical, radiographic, and ultrasonographic characteristics the were studied a cohort seventy consecutive hemophilia. We collected information on age, disease severity, history hemarthrosis, prophylaxis therapy, functional Oxford score, crutch use. Both shoulders each patient evaluated motion visual analog pain scale scores as well...
Extragonadal germ cell tumors (EGCT) are rare. They biologically distinct from their testicular counterparts. Information regarding these the Far East is limited. More investigations warranted to define optimal treatment.Retrospective review of medical records 59 patients with EGCT treated between 1983 and 2001 at a large, tertiary care institute in Taipei.The study population comprised 54 males 5 females, ranging age 1 68 years old (median age, 21 years). Primary occurred mediastinum (n =...
Necrotizing fasciitis of the thigh due to colon cancer has not been previously reported, especially during radiotherapy.A 73-year-old woman admitted our hospital was diagnosed with sigmoid that had spread left psoas muscle; radiotherapy performed. Three months after initiation radiotherapy, patient developed gait disturbance, poor appetite and high fever therefore emergency department hospital. Blood examination revealed generalized inflammation a white blood cell count C-reactive protein...
The current retrospective study aimed to investigate the relationship between prognostic factors and overall survival (OS) in patients with advanced pancreatic head cancers who initially presented obstructive jaundice. Furthermore, impact of age comorbidities on therapeutic strategies such was evaluated. A total 79 cancer were treated at our institution January 2006 November 2013 reviewed. We analyzed OS risk including sex, age, laboratory characteristics, Eastern Cooperative Oncology Group...
Background: Nilotinib, a second-generation tyrosine kinase inhibitor (TKI), is approved for the treatment of patients with chronic myeloid leukemia (CML) in many countries, including Taiwan. Though number controlled clinical trials have demonstrated safety and efficacy nilotinib, studies assessing nilotinib routine practice are limited. Methods: The current study was an open-label, single-arm conducted across 12 centers Taiwan adult CML or accelerated phase confirmed Ph+ chromosome (or...
In 10%-18% of mild-type hemophilia A (HA) patients, mutations cannot be found by routine DNA analysis.We aimed to identify the genetic defects mRNA analysis F8 gene in mild HA patients without mutation exonic DNA.From 2006 2016, we identified exon 39 49 using testing. We then evaluated 10 remaining from six unrelated families performing cDNA sequence analysis.Nine (90%) were confirmed have mutation. Eight four notably presence an aberrant 675-bp fragment. Sequencing this fragment showed that...
Renal failure is a common morbidity in multiple myeloma (MM). Although proteinuria has been increasingly reported malignancies, it not routinely used to refine risk estimates of survival outcomes patients with MM. Here we aimed investigate initial serum albumin and 24-hour daily protein excretion (24-h DPE) before treatment as prognostic factors We conducted retrospective analysis 102 who were ineligible for haematopoietic stem cell transplantation between October 2000 December 2012. Initial...
The gastrointestinal (GI) tract is the most common extranodal site of involvement in non-Hodgkin lymphoma (NHL). Primary GI NHL frequently discussed survival analyses. intestinal significantly different from primary gastric with regard to its clinical features, pathological subtype, treatment and prognosis. small intestine involved less often than large intestine. present study aimed analyze characteristics prognostic factors. A retrospective analysis was performed on data 313 cases that...
Bone marrow monocytic nodules (MNs) can occur in various myeloid disorders. This retrospective review identified 21 patients with myelodysplasia who had unusual and distinct MNs. Eight chronic myelomonocytic leukemia (CMML); 4 acute (AML); 9 myelodysplastic/myeloproliferative diseases. In each case, the cells forming MNs expressed strong CD68. appeared to persist even after aggressive chemotherapy, including conventional chemotherapy for 2 AML high-dose preceding allogeneic bone...
A 64-year-old male had bilateral renal subcapsular fluid accumulation evident on abdominal sonography performed during postoperative follow-up after surgery for a hepatoma. There were no clinical symptoms, and he history of trauma or receiving anticoagulant medication. Spontaneous hemorrhage was diagnosed series examinations. He did have an underlying myeloproliferative disorder (MPD), received incomplete cytoreductive treatment. Platelet aggregation in MPD is often abnormal, both bleeding...
Malignant bowel obstruction (MBO) is a disease with poor prognosis, particularly in patients advanced or gynecological cancers. Multimodality teatments may be used to relieve the symptoms MBO; however, there currently no consensus regarding optimal treatment and strong evidence supporting efficacy of any improving quality life (QOL) prolonging survival. We conducted search through our medical center database cancer registries for MBO cases between January, 1995 December, 2008 analyzed...