A5088731206- Cancer Treatment and Pharmacology
- Lymphoma Diagnosis and Treatment
- HER2/EGFR in Cancer Research
- Advanced Breast Cancer Therapies
- Glioma Diagnosis and Treatment
- Colorectal Cancer Treatments and Studies
- Hepatitis B Virus Studies
- Viral-associated cancers and disorders
- Lung Cancer Research Studies
- Cancer Cells and Metastasis
- Cancer Immunotherapy and Biomarkers
- Hepatitis C virus research
- Acute Myeloid Leukemia Research
- Lung Cancer Treatments and Mutations
- Monoclonal and Polyclonal Antibodies Research
- Brain Metastases and Treatment
- Cancer-related gene regulation
- Chronic Lymphocytic Leukemia Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer-related Molecular Pathways
- Hematopoietic Stem Cell Transplantation
- Bone health and treatments
- Cancer Research and Treatments
- Drug Transport and Resistance Mechanisms
- Pharmacogenetics and Drug Metabolism
Taipei Medical University
2013-2025
Taipei Medical University-Shuang Ho Hospital
2014-2024
Ministry of Health and Welfare
2022-2024
Tri-Service General Hospital
2006-2023
National Defense Medical Center
2009-2023
Columbia University
2021
Institute of Clinical Research
2020
Taipei Medical University Hospital
2020
National Health Research Institutes
2009-2010
National Taipei University of Nursing and Health Science
2010
Reactivation of hepatitis is one the most serious complications chemotherapy in lymphoma patients who are carriers B virus (HBV). Glucocorticoids linked to increased risk HBV reactivation. This study seeks clarify whether removal glucocorticoids from regimens may decrease Eligible were seropositive for surface antigen (HBsAg) and had histologically proven non-Hodgkin's lymphomas which intensive was indicated. Patients randomized receive either ACE (epirubicin, cyclophosphamide, etoposide) or...
Scope Tumor‐associated macrophages ( TAM s) have been shown to promote metastasis and malignancy. Pterostilbene, a natural stilbene isolated from blueberries, has suggested for anti‐cancer effects. Here, we explored the potential cancer stem cells CSC s)/ modulating effects of pterostilbene in breast cancer. Methods results Using flowcytometric B oyden chamber assay, showed MCF 7 MDA ‐ MB ‐231 cocultured with M 2 s exhibited increased percentage CD 44 + / 24 − population migratory/invasive...
Cancer stem cells (CSCs) promote tumor progression and distant metastasis in breast cancer. Cadherin 11 (CDH11) is overexpressed invasive cancer implicated bone metastases several cancers. The WNT signalling pathway regulates CSC activity. Growing evidence suggest that cadherins play critical roles pathway. However, CDH11 role canonical CSCs poorly understood.We investigated the functional association between triple negative (TNBC), by analyzing their expression profile TCGA Breast (BRCA)...
To assess the role of leukapheresis and cranial irradiation in reducing incidence intracranial hemorrhage (ICH) early death patients with hyperleukocytic acute myeloid leukemia (AML) impact such treatment on survival. This study retrospectively analyzed records 75 AML who had a white cell count over 100,000/microL. All de novo except for two therapy-related AML. Various factors were assessed their morbidity mortality, particularly pre-induction leukapharesis irradiation. The most significant...
The incidence of brain metastasis is increasing in patients with metastatic breast cancer. Treatments to extend the control are urgently required.
Abstract: Background: Recent data suggest that hepatitis B virus (HBV) reactivation develops in 41% of breast cancer (BC) patients carrying HBV after chemotherapy. Our study aimed to determine the role preemptive use lamivudine BC undergoing Patients and methods: The test group consisted 11 female with who were seropositive for surface antigen (HBsAg). Of these, 10 treated an adjuvant setting one metastatic disease. Lamivudine was given from start chemotherapy maintained until 1 month last...
ABSTRACT BACKGROUND Patients with triple‐negative breast cancer (TNBC) are at increased risk of brain metastases (BMs). In this retrospective single‐institutional study, we assessed the radiographic features from a cohort (BC) patients confirmed BM. METHODS Women diagnosed BC BM January 1, 1996 to May 31, 2012 were identified through institutional databases. Relevant medical records reviewed assess patterns recurrence, treatment, magnetic resonance imaging (MRI) BM, and survival after The...
3603 Background: Debio 1347 is a selective oral inhibitor of FGFR 1-3 tyrosine kinases. It exhibited high antitumor activity in vitro and vivo tumor models with FGFR1-3 gene fusions. Here we report the results expansion portion Phase 1 study advanced solid tumors patients (pts) harboring an fusion. Methods: Pts refractory fusion were enrolled. Based on from dose escalation portion, pts received Debio1347 80 mg once daily (qd) 28-day cycles. Pharmacokinetics (PK) pharmacodynamics evaluated....
Despite the significant advancement in therapeutic strategies, breast, colorectal, gastric, lung, liver, and prostate cancers remain most prevalent terms of incidence mortality worldwide. The major causes ascribed to these burdens are lack early diagnosis, high metastatic tendency, drug resistance. Therefore, exploring reliable diagnostic prognostic biomarkers universal cancer types is a clinical emergency. Consequently, present study, differentially expressed genes (DEGs) from publicly...
Molecularly targeted agents for non-small cell lung cancer (NSCLC) can provide similar efficacy to chemotherapy without chemotherapy-associated toxicities. Combining two with different modes of action could further increase the these therapies. The TASK study evaluated and safety epidermal growth factor receptor tyrosine kinase inhibitor erlotinib in combination anti-angiogenic agent bevacizumab as first-line therapy unselected, advanced non-squamous NSCLC patients.Patients were recruited...
ObjectiveTo evaluate the efficacy of intravenous ramosetron plus dexamethasone for prevention acute chemotherapy-induced nausea and vomiting.
A single transverse white band appeared on each of the fingernails a 27-year-old woman after she received induction chemotherapy with daunorubicin and cytarabine for acute myeloid leukemia. We identified bands, which did not fade digital compression, as Mees lines ([Figure 1A][1]). In
Background: Cholangiocarcinoma (CCA), an aggressive epithelial neoplasm of biliary tract, presents limited treatment options and poor overall survival. Aberrant fibroblast growth factor receptor (FGFR) signaling has been implicated in CCA carcinogenesis especially intrahepatic cholangiocarcinoma (iCCA). Debio 1347 is orally available selective FGFRi with potent antitumor effect preclinical models cancer bearing FGFR alterations. showed encouraging preliminary clinical activity manageable...
Abstract Background The study was aimed to evaluate the impact of accumulated oral tegafur‐uracil (UFUR) as maintenance chemotherapy on overall survival (OS) and disease‐free (DFS) rates after concurrent chemoradiotherapy (CCRT) for complete remission (CR) in non‐distant metastatic TNM stage IV nasopharyngeal carcinoma (NPC). Methods Data were retrospectively analyzed from a database patients with NPC, composed those who underwent CCRT CR January 2010 through December 2017. Results...
Arginine synthesis deficiency due to the suppressed expression of ASS1 (argininosuccinate synthetase 1) represents one most frequently occurring metabolic defects tumor cells. Arginine-deprivation therapy has gained increasing attention in recent years. One challenge ADI-PEG20 (pegylated ADI) is development drug resistance caused by restoration and other factors. The goal this work identify novel factors conferring resistance. Methods: Multiple, independently derived ADI-resistant clones...
Aims and objectives. This study explored the fatigue experiences in older Taiwanese women with breast cancer. Background. Cancer is a common disease for people, cancer ranks second occurrence among all cancers. Fatigue most frequently seen symptom, more than 90% of patients having such experiences. may lead to functional dependence, affecting care quality life this population. Design. A qualitative design was used study. Methods. In‐depth interviews were conducted participants being treated...
Extragonadal germ cell tumors (EGCT) are rare. They biologically distinct from their testicular counterparts. Information regarding these the Far East is limited. More investigations warranted to define optimal treatment.Retrospective review of medical records 59 patients with EGCT treated between 1983 and 2001 at a large, tertiary care institute in Taipei.The study population comprised 54 males 5 females, ranging age 1 68 years old (median age, 21 years). Primary occurred mediastinum (n =...