A5000783908- Breast Cancer Treatment Studies
- Breast Lesions and Carcinomas
- Bariatric Surgery and Outcomes
- Appendicitis Diagnosis and Management
- HER2/EGFR in Cancer Research
- Intraperitoneal and Appendiceal Malignancies
- Gastric Cancer Management and Outcomes
- Esophageal and GI Pathology
- Minimally Invasive Surgical Techniques
- Cancer Cells and Metastasis
- Ovarian cancer diagnosis and treatment
- Inflammatory mediators and NSAID effects
- Estrogen and related hormone effects
- Radiomics and Machine Learning in Medical Imaging
- Eicosanoids and Hypertension Pharmacology
- Advanced Breast Cancer Therapies
- Ferroptosis and cancer prognosis
- Epigenetics and DNA Methylation
- Biliary and Gastrointestinal Fistulas
- Hepatocellular Carcinoma Treatment and Prognosis
- PI3K/AKT/mTOR signaling in cancer
- Diverticular Disease and Complications
- Body Contouring and Surgery
- Cancer-related molecular mechanisms research
- Pharmacogenetics and Drug Metabolism
National Defense Medical Center
2015-2024
Tri-Service General Hospital
2015-2024
Case Western Reserve University
2001
Breast cancer is a life-threatening disease among women worldwide with annual rates of reported incidence and death increasing alarmingly. Chemotherapy recommended effective treatment option for breast cancer; however, the narrow therapeutic indices varied side effects currently approved drugs present major hurdles in its effectiveness. An number literature evidence indicate that complementary alternative medicine (CAM) used treatment-related symptom control alleviation plays an important...
The major cancer related mortality is caused by metastasis and invasion. It important to identify genes regulating invasion in order curtail metastatic spread of cells. This study investigated the association between RUNX2 miR-10a/miR-10b risk breast relapse. Expression levels miR-10a/b in108 pairs tumor non-tumor tissue were assayed quantitative PCR analysis evaluated for their prognostic implications. median expression miR-10b normalized using adjacent significantly higher relapsed...
ST3Gal1 is a key sialyltransferase which adds α2,3‐linked sialic acid to substrates and generates core 1 O ‐glycan structure. Upregulation of has been associated with worse prognosis breast cancer patients. However, the protein implicated in tumor progression remain elusive. In our study, we demonstrated that ST3GAL1 ‐silencing significantly reduced growth along notable decrease vascularity MCF7 xenograft tumors. We identified vasorin (VASN) was shown bind TGF‐β1, as potential candidate...
Abstract FUT1 and FUT2 encode alpha 1, 2-fucosyltransferases which catalyze the addition of 2-linked fucose to glycans. Glycan products FUT2, such as Globo H Lewis Y, are highly expressed on malignant tissues, including breast cancer. Herein, we investigated roles in Silencing or by shRNAs inhibited cell proliferation vitro tumorigenicity mice. This was associated with diminished properties cancer stem (CSC), mammosphere formation CSC marker both xenografts. but not FUT1, significantly...
Although breast phyllodes tumors are rare, there is no effective therapy other than surgery. Little known about their tumor biology. A malignant contains heterologous stromal elements, and can transform into rhabdomyosarcoma, liposarcoma osteosarcoma. These versatile properties prompted us to explore possible relationship mesenchymal stem cells (MSCs) search for the presence of cancer (CSCs) in tumors. Paraffin sections were examined various markers by immunohistochemical staining....
Overexpression of SH2-containing-5'-inositol phosphatase-2 (SHIP2) correlates with poor survival in breast cancer. However, its role cancer stem cells (BCSCs) remains unclear. Here, we showed that the percentage SHIP2(+) was positively correlated CD24(-) CD44(+) 60 specimens. Among 20 estrogen receptor (ER)-negative samples, 17 had greater SHIP2 expression subpopulation than remaining subpopulation. Data mining microarray analysis 295 tumors a significant correlation higher distant...
Background Breast cancer is a leading global health concern, necessitating advancements in recurrence prediction and management. The development of an artificial intelligence (AI)–based clinical decision support system (AI-CDSS) using ChatGPT addresses this need with the aim enhancing both accuracy user accessibility. Objective This study aims to develop validate advanced machine learning model for web-based AI-CDSS application, leveraging question-and-answer guidance capabilities enhance...
ABSTRACT BACKGROUND Patients with triple‐negative breast cancer (TNBC) are at increased risk of brain metastases (BMs). In this retrospective single‐institutional study, we assessed the radiographic features from a cohort (BC) patients confirmed BM. METHODS Women diagnosed BC BM January 1, 1996 to May 31, 2012 were identified through institutional databases. Relevant medical records reviewed assess patterns recurrence, treatment, magnetic resonance imaging (MRI) BM, and survival after The...
Abstract Background Existence of breast cancer stem cells (BCSCs) is implicated in disease relapse, metastasis, and resistance treatment. β1,3-Galactosyltransferase 5 (B3GALT5) has been shown to be a pro-survival marker for BCSCs. However, little known about the prognostic significance B3GALT5 cancer. Methods Paired tissues (tumor part adjacent non-tumor part) from cohort 202 women with were used determine expression levels mRNA by qRT-PCR. Kaplan–Meier multivariable Cox proportional hazard...
BACKGROUND Breast cancer is a leading cause of cancer-related mortality among women worldwide, with invasive ductal carcinoma (IDC) being the most prevalent subtype. Lymph node metastasis primary prognostic indicator, typically evaluated via biopsy ipsilateral sentinel or axillary lymph nodes. Contralateral (CAM) without involvement exceedingly rare, particularly in early-stage breast cancer. This report presents case CAM patient triple-negative (TNBC), underscoring diagnostic and...
// Jar-Yi Ho 1, * , Ren-Jun Hsu 2, Chih-Hsi Wu 1 Guo-Shiou Liao 3 Hong-Wei Gao Tong-Hong Wang 4 Cheng-Ping Yu 2 Department of Pathology, and Graduate Institute Pathology Parasitology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan Biobank Management Center Surgery, Tissue Bank, Chang Gung Memorial Tao-Yuan, These authors have contributed equally to this work Correspondence to: Yu, email: cpyupath@yahoo.com.tw Keywords: miR-550a-3p, ERK1, ERK2, Ras/ERK...
Current prognostic tools and targeted therapeutic approaches have limited value for metastatic triple negative breast cancer (TNBC). Building upon current knowledge, we hypothesized that epoxyeicosatrienoic acids (EETs) related CYP450 epoxygenases may differential roles in signaling, better understanding of which uncover potential directions molecular stratification personalized therapy TNBC patients.We analyzed the oxylipin metabolome paired tumors adjacent normal mammary tissues from...
Immunoglobulin-related genes are associated with the favorable prognosis of triple-negative breast cancer (TNBC) patients. We aimed to analyze function and prognostic value immunoglobulin lambda constant 2 (IGLC2) in TNBC
Abstract Background Breast cancer (BC) is the most common in women and accounts for approximately 15% of all deaths among globally. The underlying mechanism BC patients with small tumor size developing distant metastasis (DM) remains elusive clinical practices. Methods We integrated gene expression BCs from ten RNAseq datasets Gene Expression Omnibus (GEO) database to create a genetic prediction model metastasis-free survival (DMFS) sizes (≤ 2 cm) using weighted co-expression network (WGCNA)...
Patients with clinical T4 gastric cancers have high recurrence rates and low 5-year overall survival (OS) despite radical gastrectomy D2 lymphadenectomy adjuvant chemotherapy. The invisible peritoneal metastasis may result in local due to the tumor invading serosa nearby organs. Prophylactic hyperthermic intraperitoneal chemotherapy (HIPEC) has been suggested as an treatment strategy these patients. We evaluated efficacy of prophylactic HIPEC post-gastrectomy for patients cancer.We...
Sleep disordered breathing (SDB) and hypertension are commonly associated. In this study, we assessed how longitudinal measures of SDB predict a 24-h ambulatory blood pressure monitoring (ABPM) profile. Participants (n = 82) were recruited from community-based urban (26% African American) sample included family members patients with laboratory diagnosed (cases) neighborhood control subjects evaluated at baseline 5 years. Nearly all participants normotensive not receiving therapy for SDB....
We evaluated the outcomes of laparoscopic repair perforated peptic ulcers using simple closure only. This retrospective study included 79 patients who underwent from January 2011 to February 2016. They were divided into two groups: with an omental patch and All them peritoneal cavity lavage several litres warm normal saline. A closed suction drain system was placed for drainage intra-abdominal abscess. Patients' age, sex, Boey score, perforation size, operation time, overall complications,...