A5031636838- Eicosanoids and Hypertension Pharmacology
- Pharmacogenetics and Drug Metabolism
- Genetic Associations and Epidemiology
- Metabolomics and Mass Spectrometry Studies
- Inflammatory mediators and NSAID effects
- RNA modifications and cancer
- Genetic and phenotypic traits in livestock
- Lipid metabolism and biosynthesis
- Cancer-related molecular mechanisms research
- Traditional Chinese Medicine Studies
- Computational Drug Discovery Methods
- Fatty Acid Research and Health
- Advanced Proteomics Techniques and Applications
- Chronic Lymphocytic Leukemia Research
- Nutritional Studies and Diet
- Endoplasmic Reticulum Stress and Disease
- Cancer, Hypoxia, and Metabolism
- Advanced Chemical Sensor Technologies
- Diabetes and associated disorders
- Genetic Mapping and Diversity in Plants and Animals
- Gene expression and cancer classification
- Gut microbiota and health
Institute of Statistical Science, Academia Sinica
2012-2022
National Taiwan University
2012-2016
Academia Sinica
2009
Institute of Biomedical Sciences, Academia Sinica
2005
Rheumatoid arthritis (RA) is a chronic inflammatory disorder with polygenic mode of inheritance. This study examined the hypothesis that runs homozygosity (ROHs) play recessive-acting role in underlying RA genetic mechanism and identified RA-associated ROHs. Ours first genome-wide association for characterized ROH patterns associated genomes 2,000 patients 3,000 normal controls Wellcome Trust Case Control Consortium. Genome scans consistently pinpointed two regions within human major...
Microsomal triglyceride transfer protein (MTTP) is an endoplasmic reticulum resident that essential for the assembly and secretion of (TG)-rich, apoB-containing lipoproteins. Although function structure mammalian MTTP have been extensively studied, how exactly transfers lipids to lipid acceptors whether there are other biomolecules involved in MTTP-mediated transport remain elusive. Here we identify a role this process poorly characterized PRAP1. We report PRAP1 partially colocalized...
Metabolomics data provide unprecedented opportunities to decipher metabolic mechanisms by analyzing hundreds thousands of metabolites. Data quality concerns and complex batch effects in metabolomics must be appropriately addressed through statistical analysis. This study developed an integrated analysis tool for studies streamline the complete flow from initial preprocessing downstream association We Statistical Analysis-An R Tool (SMART), which can analyze input files with different...
Current prognostic tools and targeted therapeutic approaches have limited value for metastatic triple negative breast cancer (TNBC). Building upon current knowledge, we hypothesized that epoxyeicosatrienoic acids (EETs) related CYP450 epoxygenases may differential roles in signaling, better understanding of which uncover potential directions molecular stratification personalized therapy TNBC patients.We analyzed the oxylipin metabolome paired tumors adjacent normal mammary tissues from...
Genome-wide association studies, which analyzes hundreds of thousands single-nucleotide polymorphisms to identify disease susceptibility genes, are challenging because the work involves intensive computation and complex modeling. We propose a two-stage genome-wide scanning procedure, consisting single-locus scan for first stage gene-based second stage. Marginal effects examined by using exact Armitage trend test or logistic regression, gene p-value combination method. Compared with some...
Lipids account for a high proportion of dietary calories, which greatly affect human health. As result differences in composition fatty acid individual cooking oils, certain biological effects these oils may vary. This study aimed to compare postprandial metabolomic profiles six commonly consumed oils/fats. Adopting switch-over experimental design (n = 15), we carried out feeding with groups (control without soybean oil, olive palm camellia and tallow) collected fasting serum samples. The...
Various groups of antihypertensive drugs targeting different pathways have been developed; however, the pharmacometabolic responses to these rarely compared elucidate common pathway blood pressure regulation. Here, we performed a comparative multi-dimensional study on four major lines drugs, namely angiotensin-converting enzyme inhibitors (ACEis), angiotensin receptor blockers (ARBs), calcium channel (CCBs), and diuretics (DIURs), through ultra-performance liquid chromatography coupled...
Meta-analysis is a method for enhancing statistical power through the integration of information from multiple studies. Various methods integrating p-values (i.e., significance), including Fisher's under an independence assumption, permutation method, and decorrelation have been broadly used in bioinformatics computational biotechnology However, these limitations related to computing efficiency, accuracy significance estimation. In this study, we proposed numerical examined its theoretical...
Examination of changes in urinary metabolomic profiles after vegetable ingestion may lead to new methods assessing plant food intake. To this regard, we developed a proof-of-principle methodology identify signatures for spinach, celery, and onion. Three feeding studies were conducted. In the first study, healthy individuals fed with onion, no vegetables four separate experiments pooled samples metabolite discovery. The same protocol was used validate finding at individual level second study...
Abstract Endophenotypes such as behavior disorders have been increasingly adopted in genetic studies for complex traits. For efficient gene mapping, it is essential that an endophenotype associated with the disease of interest and inheritable or co-segregating within families. In this study, we proposed a strategy to construct endophenotypes analyze Genetic Analysis Workshop 14 simulated dataset. Initially, generalized estimating equation models were employed identify phenotypes correlated...