A5036638776- Cancer Cells and Metastasis
- Peptidase Inhibition and Analysis
- Multiple Myeloma Research and Treatments
- Epigenetics and DNA Methylation
- Ferroptosis and cancer prognosis
- Neuroinflammation and Neurodegeneration Mechanisms
- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Cancer Immunotherapy and Biomarkers
- Fibroblast Growth Factor Research
- MicroRNA in disease regulation
- Head and Neck Cancer Studies
- Cancer-related molecular mechanisms research
- Advanced machining processes and optimization
- Cancer, Lipids, and Metabolism
- Protein Degradation and Inhibitors
- Breast Lesions and Carcinomas
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Proteoglycans and glycosaminoglycans research
- Pharmacological Effects and Toxicity Studies
- Autophagy in Disease and Therapy
- Circular RNAs in diseases
- Cancer Diagnosis and Treatment
- Advanced Breast Cancer Therapies
- Hedgehog Signaling Pathway Studies
National Defense Medical Center
2010-2024
Tri-Service General Hospital
2014-2024
Taipei Medical University
2016-2020
National Cheng Kung University
2019
National University of Formosa
2018
National Formosa University
2018
Taipei Tzu Chi Hospital
2015
China Medical University
2010-2012
National Yang Ming Chiao Tung University
2012
Guangzhou First People's Hospital
2011
Oral squamous cell carcinoma (OSCC) is among the most commonly diagnosed malignancies in world. Patients with OSCC often develop treatment resistance, resulting a poor prognosis. Mounting evidence indicates that interactions between cancerous cells and other components of tumor microenvironment (TME) determine their response to treatment. Herein, we examined role cancer stem cell-derived extracellular vesicles (CSC_EVs) generated from CAL27 SCC-15 development cisplatin (CDDP) resistance. We...
Ghrelin is a newly discovered gastric peptide which stimulates food intake, energy balance, and growth hormone release. Recent reports have also shown that circulating ghrelin can efficiently reach the brain. However, molecular mechanisms pathophysiologic roles underlying ghrelin-induced glioma migration remain unclear. Glioma most common primary adult brain tumor with poor prognosis because of spreading cell to other regions easily. In present study, we found application recombinant human...
Increasing studies suggest that inflammatory processes in the central nervous system mediated by microglial activation plays an important role numerous neurodegenerative diseases. Development of planning for suppression is considered a key strategy search neuroprotection. Paeonol major phenolic component Moutan Cortex, widely used as nutrient supplement Chinese medicine. In this study, we investigated effects paeonol on cells stimulated inflammagens. significantly inhibited release nitric...
Signal transducer and activator of transcription 3 (STAT3)/Cyclin-dependent kinases are multifunctional proteins that play an important implicative role in cancer initiations, progression, drug resistance, metastasis, has been extensively explored therapy. However, the genetic alterations STAT3/CDK2/4/6 its predicting immune infiltration immunotherapeutic response yet to be well exploited. In this study, we use silico methods analyze differential expression, prognostic value, epigenetic...
We recently reported that peptidoglycan (PGN), a cell wall component of the Gram-positive bacterium, induces NF-κB activation and microglia activation. However, PGN-regulated AP-1 cytokine expression in remains unclear. This study investigated how PGN influences signaling pathway involved IL-6 production microglia. mRNA protein level up-regulation were increased by concentration- time-dependent manner. In addition, toll-like receptor-2 (TLR2) expression, but not TLR4 receptor up-regulation....
Despite advancements in diagnostic and standard treatment modalities, including surgery, radiotherapy, chemotherapy, overall survival rates of advanced-stage head neck squamous cell carcinoma (HNSCC) patients have remained stagnant for over three decades. Failure these coupled with post-therapy complications, underscores the need alternative interventions an in-depth understanding complex signaling networks involved developing resistance. Using bioinformatics tools, we identified increased...
Metastasis is a leading cause of breast cancer mortality. The induction epithelial-to-mesenchymal transition (EMT) and complex oncogenic signaling vital step in the evolution highly metastatic therapeutically-intractable cancer; necessitating novel target discovery or development therapeutics that cells (MBCs).To achieve this, this study employs combination silico bioinformatics analyses, protein transcript drug sensitivity assays, functional assays animal studies.The present identified...
This study is the first to investigate anticancer effects of new phloroglucinol derivative (3,6-bis(3-chlorophenylacetyl)phloroglucinol; MCPP) in human colon cancer cells. MCPP induced cell death and antiproliferation three cancer, HCT-116, SW480, Caco-2 cells, but not primary dermal fibroblast MCPP-induced concentration-dependent apoptotic cells was measured by fluorescence-activated sorter (FACS) analysis. Treatment HCT-116 with found induce a number signature endoplasmic reticulum (ER)...
Resistin is originally reported as an adipose tissue-specific hormone and thought to represent a link between obesity insulin-resistant diabetes. Adipokines exert energy-regulation has been have neuroprotective effect like leptin, adiponectin, ghrelin. However, the role of resistin in not explored. 6-hydroxydopamine (6-OHDA), one most investigated Parkinson's disease neurotoxins, widely used study mechanisms cell death dopaminergic neurons. In present study, our results show that treatment...
Patients with diffuse large B-cell lymphoma (DLBCL) concurrent hepatitis B surface antigen (HBsAg)-positive virus (HBV) infection have distinct clinical features. Nevertheless, the prognostic value of HBsAg in DLBCL rituximab era remains unclear.We conducted a retrospective cohort study to investigate relevance immunocompetent patients treated homogeneous plus cyclophosphamide, doxorubicin, vincristine, and prednisone between 2002 2016.Among 416 analyzed patients, 98 (23.6%) were positive....
Abstract Background The study was aimed to evaluate the impact of accumulated oral tegafur‐uracil (UFUR) as maintenance chemotherapy on overall survival (OS) and disease‐free (DFS) rates after concurrent chemoradiotherapy (CCRT) for complete remission (CR) in non‐distant metastatic TNM stage IV nasopharyngeal carcinoma (NPC). Methods Data were retrospectively analyzed from a database patients with NPC, composed those who underwent CCRT CR January 2010 through December 2017. Results...
Trastuzumab-containing treatment regimens have been shown to improve survival outcomes in HER2-positive breast cancer (BC). It is much easier infuse a fixed one-vial dose every patient on regular schedule the general clinical setting. The aims of this study were evaluating efficacy 440 mg fixed-dose trastuzumab administered monthly infusion schedule, and risk factors for cardiac events.We retrospectively reviewed data from 300 BC patients our institute: 208 early-stage undergoing adjuvant...
The role and therapeutic promise of poly-ADP ribose polymerase (PARP) inhibitors in anticancer chemotherapy are increasingly being explored, particularly adjuvant or maintenance therapy, considering their low efficacy as monotherapy agents potentiating effects on concurrently administered contemporary chemotherapeutics. Against the background increasing acquired resistance to FGFR1 our previous work, which partially demonstrated caspase-3/PARP-mediated antitumor antimetastatic PD173074, a...
Myeloma‑associated kidney disease (MRKD) occurs in ≤40% patients with multiple myeloma (MM). The impact of hemodialysis (HD) on MM was investigated. Between 2000 and 2010, a total 1,610 Taiwan were enrolled from the National Health Institute Research Database. an independent risk factor for HD following adjustment via multivariate logistic regression analysis (adjusted hazard ratio, 7.347; 95% confidence interval, 6.156‑8.768; log‑rank test, P<0.001). In addition, notable decrease survival...
In a retrospective cohort study, we report the current epidemiology of patients with multiple myeloma (MM) and analyze real-world clinical outcomes bortezomib-based therapy.This study was mainly designed to evaluate characteristics, treatment outcomes, prognostic factors MM who received therapy. We identified 5,726 in Taiwan newly diagnosed between 2007 2015. Confidential data from National Health Insurance Research Database (NHIRD) used under strict guidelines, as it made available an...
An electron bunch (e-bunch) passing through an insulator-metal-insulator (IMI) substrate can excite surface plasmons (SPs) on the substrate. Recent studies demonstrate that Smith-Purcell radiation (SPR) from one-dimensional gratings IMI be manipulated and enhanced by e-bunch excited SPs. However, under this configuration, only emission along direction of moving controlled. To steer both azimuthal polar angles far-field pattern requires other mechanisms. In work, SP-manipulated SPR with a...
The aim of the present study was to investigate association between cluster differentiation (CD) 164 expression with clinicopathological parameters and prognosis among patients oral cavity squamous cell carcinoma (OSCC). retrospectively reviewed 70 OSCC who underwent curative primary surgery. A number subsequently received postoperative chemoradiotherapy although specimens were not exposed radiation or chemotherapy prior anti-CD164 antibody immunohistochemical staining. CD164 overexpression...