A5019857041- Ferroptosis and cancer prognosis
- PI3K/AKT/mTOR signaling in cancer
- Influenza Virus Research Studies
- Cancer Mechanisms and Therapy
- Kruppel-like factors research
- Cancer-related gene regulation
- Cancer, Lipids, and Metabolism
- Extracellular vesicles in disease
- Epigenetics and DNA Methylation
- Immune Response and Inflammation
- Cancer-related molecular mechanisms research
- Cytokine Signaling Pathways and Interactions
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Systemic Lupus Erythematosus Research
- Heme Oxygenase-1 and Carbon Monoxide
- Aluminum toxicity and tolerance in plants and animals
- Axon Guidance and Neuronal Signaling
- Medical Imaging and Pathology Studies
- Protease and Inhibitor Mechanisms
- Invertebrate Immune Response Mechanisms
- Phagocytosis and Immune Regulation
- Bone and Dental Protein Studies
- Magnesium Alloys: Properties and Applications
- Fungal Biology and Applications
- Escherichia coli research studies
Taipei Medical University-Shuang Ho Hospital
2021-2025
Taipei Medical University
2020-2024
Taipei Medical University Hospital
2020
National Taiwan University
2012-2019
Background: Research has demonstrated that some tumor cells can transform into drug-tolerant persisters (DTPs), which serve as a reservoir for the recurrence of disease. The persister state in cancer arises due to temporary molecular reprogramming, and exploring genetic composition microenvironment during development head neck squamous cell carcinoma (HNSCC) enhance our comprehension types death HNSCC, thus identifying potential targets innovative therapies. This project investigated...
Renal cell carcinoma (RCC) is the predominant form of malignant kidney cancer. Sunitinib, a primary treatment for advanced, inoperable, recurrent, or metastatic RCC, has shown effectiveness in some patients but increasingly limited by drug resistance. Recently identified cuproptosis, copper-ion-dependent programmed death, holds promise combating cancer, particularly drug-resistant types. However, its treating resistant RCC remains to be determined. Exploring cuproptosis's regulatory...
The third-generation epidermal growth factor receptor (EGFR) inhibitor, Osimertinib, is used to treat non-small cell lung cancer (NSCLC) patients with tyrosine kinase inhibitor (TKI) resistance caused by acquired EGFR T790M mutation. However, eventually develop against Osimertinib mechanisms not yet fully clarified. Activated alternative survival pathways within the tumor cells and cancer-associated fibroblasts (CAFs) have been proposed contribute resistance. MET MEK inhibitors may overcome...
Treating advanced colon cancer remains challenging in clinical settings because of the development drug resistance and distant metastasis. Mechanisms underlying metastasis are complex unclear.Computational analysis was performed to determine genes associated with exosomal long noncoding (lncRNA) plasmacytoma variant translocation 1 (PVT1)/vascular endothelial growth factor A (VEGFA) axis patients cancer. The biological importance lncRNA PVT1/VEGFA examined vitro by using HCT116 LoVo cell...
Abstract Locally advanced oral squamous cell carcinoma (OSCC) requires multimodal therapy, including surgery and concurrent chemoradiotherapy (CCRT). CCRT-resistant recurrent cancer has a poor prognosis. We investigated the effects of Bruton’s tyrosine kinase (BTK) on OSCC tissues. The effect ibrutinib, first-in-class BTK inhibitor, was tested stem cell-like tumorspheres. A tissue array constructed using samples from 70 patients with OSCC. Human lines, SAS, TW2.6 HSC-3, were examined. Wound...
The exact mechanisms of Head and neck squamous carcinoma (HNSCC) chemoresistance metastatic transformation remain unclear. In recent decades, members the transient receptor potential (TRP) channel family have been proposed as biomarkers and/or drug targets in cancer treatment. First, a TCGA cohort HNSCC, TRPM7 is highly expressed tissues, especially expression invasive tissues statistically significant (p>0.001). GEO cohort, patients with high NFATC2 poor overall survival rates. showed...
Background: Hepatitis virus is a major risk factor for liver cancer. The mitochondrial dysfunction IFN gamma-related pathways are activated after infection. Jak family-related protein involved in the downstream of pathways. However, effect IFNGR-JAK-STAT pathway acting as functional regulators their related expression on infection and hepatocellular carcinoma (HCC) remains unclear. Interestingly, role DNA repair gene (PARP1) therapy resistant cancers also has not been studied explored well....
Head and neck squamous cell carcinoma (HNSCC) is a major contributor to cancer incidence globally currently managed by surgical resection followed adjuvant chemoradiotherapy. However, local recurrence the cause of mortality, indicating emergence drug-tolerant persister cells. A specific histone demethylase, namely lysine-specific demethylase 5D (KDM5D), overexpressed in diverse types cancers involved cycle regulation. role KDM5D development cisplatin-tolerant cells remains unexplored. Here,...
Background. Despite therapeutic advancements, metastasis remains a major cause in breast cancer-specific mortality. Breast cancer cells are susceptible to oxidative damage and exhibit high levels of stress, including protein damage, DNA lipid peroxidation. Some risk factors may change the level endogenous stress. Circulating exosomes play critical roles tumorigenesis, distant metastasis, poor prognosis patients with cancer. Methods. We used an online database analyze expression prognostic...
Oral squamous cell carcinoma (OSCC) is a prevalent type of oral cancer. While therapeutic innovations have made strides, radioresistance persists as significant hindrance in OSCC treatment. Despite identifying numerous targets that could potentially suppress the oncogenic attributes OSCC, exploration protein kinases for cancer therapy remains limited. Consequently, functions many kinase proteins continue to be largely undetermined. In this research, we aim disclose target and elaborate their...
Abstract The authors have requested that this preprint be removed from Research Square.
Abstract The authors have requested that this preprint be removed from Research Square.
Abstract The authors have requested that this preprint be removed from Research Square.
Abstract Hepatocellular carcinoma (HCC) represents one of the most prevalent and lethal type malignancies around globe. Despite advancement in medical research therapeutics development, HCC still remains a taunting challenge clinical settings. Recent studies indicate that presence cancer stem cells (CSCs) may be underlying factor for treatment failure, distant metastasis, disease recurrence. Elevated stemness gene expression has been correlated to stage poorer prognosis patients. Initially,...
Background: Antiphospholipid syndrome (APS) is an autoimmune disorder with increased risk for thrombosis and pregnancy losses. There no current consensus concerning the efficacy of this treatment in secondary prevention thrombotic events primary APS. Hydroxychloroquine has recently demonstrated its benefits several vitro experimental animal model data.Methods: In study, therapeutic effects hydroxychloroquine (HCQ) analogs were evaluated under pathological conditions ex vivo. We will focus on...