A5061013354- Biosensors and Analytical Detection
- Gold and Silver Nanoparticles Synthesis and Applications
- Advanced biosensing and bioanalysis techniques
- Gas Sensing Nanomaterials and Sensors
- Advanced Chemical Sensor Technologies
- Electrochemical sensors and biosensors
- Cancer, Hypoxia, and Metabolism
- Pharmacological Effects and Assays
- Immune cells in cancer
- Advanced Nanomaterials in Catalysis
- Melamine detection and toxicity
- GDF15 and Related Biomarkers
- Macrophage Migration Inhibitory Factor
- Cancer Immunotherapy and Biomarkers
- Nuclear Receptors and Signaling
- Conducting polymers and applications
- Electromagnetic wave absorption materials
- Paraquat toxicity studies and treatments
- Ferroptosis and cancer prognosis
- Polydiacetylene-based materials and applications
- Extracellular vesicles in disease
- Cancer survivorship and care
- Health and Wellbeing Research
- Food Safety and Hygiene
- Advanced Sensor and Energy Harvesting Materials
National Defense University
2017-2024
Mackay Memorial Hospital
2012-2023
Mackay Medical College
2019-2023
Taipei Medical University Hospital
2020
The third-generation epidermal growth factor receptor (EGFR) inhibitor, Osimertinib, is used to treat non-small cell lung cancer (NSCLC) patients with tyrosine kinase inhibitor (TKI) resistance caused by acquired EGFR T790M mutation. However, eventually develop against Osimertinib mechanisms not yet fully clarified. Activated alternative survival pathways within the tumor cells and cancer-associated fibroblasts (CAFs) have been proposed contribute resistance. MET MEK inhibitors may overcome...
It is important to be able detect melamine
We developed a smartphone-assisted microchemistry analyzer for the quantitative detection of carbofuran using paper-based colorimetric sensor, Photoshop software, and smartphone app.
A colloidal silver nanoparticle (AgNP)-based lateral flow immunoassay (LFIA) was evaluated in terms of the rapid detection profenofos (PEO) pesticide residue vegetables. Colloidal AgNPs, a diameter approximately 20 nm, were surface-modified with trisodium citrate dehydrate (TSC) order to improve their stability and dispersion. An anti-profenofos polyclonal antibody (pAb) successfully immobilized on surface AgNPs by ionic interaction characterized using UV-vis, SEM, TEM, FTIR XPS analyses....
A recent study suggested that solute carrier family 35 member A2 (SLC35A2) is related to poor prognosis in patients with breast cancer. SLC35A2 transports uridine diphosphate-galactose from the cytosol lumen of endoplasmic reticulum and Golgi.Immunohistochemical expression was evaluated using tissue microarrays. Cell growth, migration, invasion cancer cells were examined following loss- gain-of-expression SLC35A2.Normal exhibited immunoreactivity nucleus. progressive increase cytoplasmic...
Fipronil (FP) is a very effective phenylpyrazole insecticide and now widely used in agriculture. At the same time, water soil environment are polluted by FP. For rapid detection of FP toxicants food environment, we have designed an entirely novel electrochemical immunosensor that employs combined functionalities cMWCNTs-AgNPs-CS-FAb-BSA layer to modify SPCE freeze-drying technique. The high porosity chitosan (CS) coupled with excellent electron transfer enabled cMWCNTs AgNPs increased...
It is both important and required to quickly accurately detect chemical warfare agents, such as the highly toxic nerve agent sarin. Surface-enhanced Raman scattering (SERS) has received considerable attention due its rapid results, high sensitivity, non-destructive data acquisition, unique spectroscopic fingerprint. In this work, we successfully prepared SERS cotton swabs (CSs) for detection of sarin simulant dimethyl methyl phosphonate (DMMP) by anchoring N1-(3-trimethoxysilylpropyl)...
Magnetite nanoparticles (MNPs) Fe3O4 and r-Fe2O3 were surface-modified with poly(ethylene glycol) (PEG) in order to improve their specificity bioactivity. PEG the anti-MEL monoclonal antibody (mAb) successfully immobilized on surface of MNPs characterized using FTIR, UV-Vis TEM analyses. Surface modification MNPs-PEG-mAb conjugates a variety sizes magnetite types was employed design prepare labels for use lateral flow immunoassay (LFIA) test whether size conjugate can affect performance...
Background: Recently we demonstrated that Astragalus polysaccharide (PG2), the active ingredient in dried roots of astragalus membranaceus, ameliorates cancer symptom clusters and improve quality life (QoL) patients with metastatic disease by modulating inflammatory cascade, against background cells including macrophages, dendritic (DCs), cytotoxic T lymphocytes (CTLs) tumor initiation, metastasis, progression. Nevertheless, role PG2 modulation anticancer immunogenicity therapeutic response...
Background. Despite therapeutic advancements, metastasis remains a major cause in breast cancer-specific mortality. Breast cancer cells are susceptible to oxidative damage and exhibit high levels of stress, including protein damage, DNA lipid peroxidation. Some risk factors may change the level endogenous stress. Circulating exosomes play critical roles tumorigenesis, distant metastasis, poor prognosis patients with cancer. Methods. We used an online database analyze expression prognostic...
A sensitive breath sensor for real-time detection of apnea is important in medical care. We aim to construct a flexible platform with integration carbon nanotubes (CNTs) and related electromechanical system the respiratory Through acid-treated process, multiwalled (MWCNTs) are immobilized on heated silicon wafer. Chromium gold then implemented MWCNT film develop micro interdigitated electrodes as base sensor. The mini-sensor mounted connecting tube equipped programmed microchip processor...
A colloidal silver nanoparticle (AgNP)-based lateral flow immunoassay (LFIA) was developed using an antifipronil polyclonal antibody (fAb), and its employment for the rapid detection of residual fipronil in spiked egg, honey, tea human urine samples studied. The fAb successfully immobilized on AgNP surface by ionic interactions characterized Bradford method, UV-Vis, SEM, TEM XPS analyses. visible limit optical test strip were 40 2.0 ppb, respectively, standard solution. This assay showed no...
Abstract Organic–inorganic composite antibacterial materials based on AgPc/Ag and aminosilane-modified silicate (Ormosil) were prepared by sol-gel processes an in situ reduction method. The physical chemical properties of AgPc, Pc-Ormosil AgPc-Ormosil/Ag composites analyzed SEM, XRD, NMR XPS spectroscopy. As a result, Ag nanoparticles bonded chelated matrix. morphology analysis SEM showed that the AgNPs matrix spherical uniformly distributed, with size about 5–10 nm. These results indicated...
Abstract Organic–inorganic composite antibacterial materials based on silver phthalocyanine-silver (AgPc/Ag) and aminosilane-modified silicate (Ormosil) were synthesized by sol-gel method in-situ reduction method. The objective of this study was not only the synthesis Pc-Ormosil AgPc-Ormosil/Ag composites but also investigated bacteriostatic ability modified fabrics relationship between property content non-woven fabric discussed. Moreover, laundering durability AgPc-Ormosil/Ag-treated...