A5068278994- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Breast Cancer Treatment Studies
- Cancer Cells and Metastasis
- Cancer-related molecular mechanisms research
- Breast Lesions and Carcinomas
- MicroRNA in disease regulation
- Sleep and related disorders
- Ubiquitin and proteasome pathways
- Breast Implant and Reconstruction
- Cancer-related Molecular Pathways
- Cancer-related gene regulation
- Anesthesia and Pain Management
- Angiogenesis and VEGF in Cancer
- Pregnancy-related medical research
- Lymphatic System and Diseases
- HER2/EGFR in Cancer Research
- Bladder and Urothelial Cancer Treatments
- Cancer Genomics and Diagnostics
- Cancer, Stress, Anesthesia, and Immune Response
- Musculoskeletal pain and rehabilitation
- Chronic Lymphocytic Leukemia Research
- Medicinal plant effects and applications
- Vascular anomalies and interventions
- Acupuncture Treatment Research Studies
Taipei Medical University
2014-2025
Taipei Medical University-Shuang Ho Hospital
2015-2025
Chang Gung University
2007
Lactate dehydrogenase A (LDHA) can regulate tumorigenesis and cancer progression. Nevertheless, whether the regulation of LDHA is involved in development gemcitabine resistance PDAC has not yet been fully elucidated. Increasing studies have shown that acquired drug led to treatment failure highly attributed stem cell (CSC) properties. Therefore, we aim demonstrate functions regulatory mechanisms on properties PDAC. We investigate metabolite profiles by liquid chromatography-mass spectrometry...
$('.header-date').hide();$('#titleAuthors').hide();$('#abstractHeader').hide(); Yi-Wen Chang 1 , 2 3 * Chih-Ming Su 4 5 Yen-Hao Yuan-Soon Ho 6 Hui-Huang Lai 7 Hsin-An Chen Min-Liang Kuo 8 Wen-Chun Hung Ya-Wen Chih-Hsiung Wu Pai-Sheng 9 Jen-Liang 10 11 12 Graduate Institute of Biochemistry and Molecular Biology, National Yang-Ming University, Taipei 112, Taiwan Genomics Research Center, Academia Sinica, 115, Cancer Research, Health Institutes, Miaoli 35053, Clinical Medicine, College Medical...
Breast cancer is one of the most prevalent gynecologic malignancies worldwide. Despite high sensitivity in response to chemotherapy, drug resistance occurred frequently clinical treatment. Cryptotanshinone (CTS) a herbal medicine and has been identified as an anti-inflammatory anti-oxidative drug.In vitro assays, including cell proliferation assay, colony formation Western blot analysis, transwell migration/invasion scratch assay were used explore biological activities working mechanism CTS....
Intra-abdominal cystic lymphangiomas are rare and usually present as benign large masses. The treatment of choice mesenteric retroperitoneal is surgical resection.Seventeen adults, 11 male 6 female, with a median age 39 years were investigated. Presentation, treatment, outcomes the analyzed.The most common symptom was abdominal pain. tumour size 12.0 cm in diameter. Patients younger (p=0.043). However, 4 out 8 patients type required bowel resection (p=0.064). Magnetic resonance imaging...
The early detection of cancer can reduce cancer-related mortality. There is no clinically useful noninvasive biomarker for breast cancer. aim this study was to develop accurate and precise biomarkers a dynamic monitoring system following treatment. We analyzed genome-wide methylation array in Taiwanese Cancer Genome Atlas (TCGA) (BC) patients. Most cancer-specific circulating methylated CCDC181, GCM2 ITPRIPL1 were found the plasma. An automatic analysis process ccfDNA established. A combined...
Abstract Background Approximately 25% of patients with early-stage breast cancer experience progression throughout the disease course. Alterations in TMEM240 were identified and investigated to monitor treatment response progression. Methods Circulating methylated plasma was used The Cancer Genome Atlas (TCGA) data Western countries Illumina methylation arrays Taiwanese identify novel hypermethylated CpG sites genes related poor hormone therapy response. Quantitative methylation-specific PCR...
Background . Survivin is a member of the inhibitors apoptosis protein family that plays an important role in carcinogenesis. Here, we examined association between survivin expression and clinical outcome urothelial carcinoma bladder (UCB). Methods A total 56 histopathologically confirmed UCB patients were recruited from Department Urology Chiayi Christian Hospital August 2007 to May 2009. Immunohistochemistry (IHC) was used detect tumor tissues. The –31 C/G polymorphism promoter region...
// Chih-Ming Su 1, 2 , Ting-Yu Chang 3 Hui-Ping Hsu 4 Hui-Huang Lai 5, 6 Jie-Ning Li Yu-Jhen Lyu Kuang-Tai Kuo 7, 8 Ming-Te Huang Jen-Liang 3, 9, 10, 11 Pai-Sheng Chen 1 Division of General Surgery, Department School Medicine, College Taipei Medical University, City, Taiwan, ROC Shuang Ho Hospital, New National Institute Cancer Research, Health Research Institutes, Zhunan, Miaoli Country, Cheng Kung University Tainan, 5 Basic Sciences, Laboratory Science and Biotechnology, 7 Thoracic 9...
Epigenetic alterations play a pivotal role in cancer treatment outcomes. Using the methylation array data and The Cancer Genome Atlas (TCGA) dataset, we observed hypomethylation upregulation of thiosulfate sulfurtransferase-like domain containing 1 (TSTD1) patients with breast cancer. We examined paired tissues from Taiwanese that 65.09% 68.25% exhibited TSTD1 overexpression, respectively. A significant correlation was found between overexpression (74.2%, p = 0.040) Western (88.0%, < 0.001)...
Background. Despite therapeutic advancements, metastasis remains a major cause in breast cancer-specific mortality. Breast cancer cells are susceptible to oxidative damage and exhibit high levels of stress, including protein damage, DNA lipid peroxidation. Some risk factors may change the level endogenous stress. Circulating exosomes play critical roles tumorigenesis, distant metastasis, poor prognosis patients with cancer. Methods. We used an online database analyze expression prognostic...
Distant metastasis is the leading cause of death in patients with breast cancer. Despite considerable treatment advances, clinical outcomes metastatic cancer remain poor. CSCs can self-renew, enhancing progression and metastasis. Dicer, a microRNA (miRNA) processing-related enzyme, required for miRNA maturation. Imbalanced Dicer expression may be pivotal progression. However, whether how affects stemness cells remains unclear. Here, we hypothesized that regulates migration, invasion, cells....
Breast cancer is a leading cause of mortality in women worldwide. Using the Infinium MethylationEPIC BeadChip, we analyzed plasma sample methylation to identify
Abstract Objective Urothelial carcinoma (UC) which is derived from the urothelium of urinary tract includes cancers bladder, renal pelvis and ureter. The aim this study was to compare clinical demographic features between bladder upper urothelial in Taiwan. Material methods present recruited a total 736 histopathological confirmed UC cases, consisted 470 cancer 266 (UTUC) cases. Clinical characteristics were collected by structured question interview medical chart review. This approved...