A5054499877- Pancreatic and Hepatic Oncology Research
- Phagocytosis and Immune Regulation
- Cancer, Hypoxia, and Metabolism
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Protease and Inhibitor Mechanisms
- RNA modifications and cancer
- Cancer Mechanisms and Therapy
- Cancer Cells and Metastasis
- Virus-based gene therapy research
- Anodic Oxide Films and Nanostructures
- Liver Disease Diagnosis and Treatment
- Microtubule and mitosis dynamics
- Diet and metabolism studies
- Esophageal Cancer Research and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer therapeutics and mechanisms
- Gut microbiota and health
- Peptidase Inhibition and Analysis
- Advanced Breast Cancer Therapies
- Epigenetics and DNA Methylation
- Angiogenesis and VEGF in Cancer
- RNA Research and Splicing
- Fatty Acid Research and Health
- Molecular Biology Techniques and Applications
Taipei Medical University
2018-2025
Taipei Medical University-Shuang Ho Hospital
2022-2025
Taipei Medical University Hospital
2020-2024
Agricultural Technology Research Institute
2022-2023
National Health Research Institutes
2014-2017
Agricultural Biotechnology Research Center, Academia Sinica
2008-2016
Institute of Cancer Research
2016
Chang Gung Memorial Hospital
2014
National Cheng Kung University
2011-2012
Academia Sinica
2011-2012
Of a group of 312 non-Hispanic Caucasians who smoked at least one pack per day, had unsuccessfully attempted to stop smoking, and were free alcohol or other drug dependence, 48.7% carried the A 2 allele DRD2 gene. This was significantly greater than 25.9% prevalence in 714 known Caucasian controls without abuse, p<10-8, smaller set our study controls. There significant, inverse relationship between D2A1 age onset p=0.02, maximum duration time smokers been able quit smoking on their own,...
Lactate dehydrogenase A (LDHA) can regulate tumorigenesis and cancer progression. Nevertheless, whether the regulation of LDHA is involved in development gemcitabine resistance PDAC has not yet been fully elucidated. Increasing studies have shown that acquired drug led to treatment failure highly attributed stem cell (CSC) properties. Therefore, we aim demonstrate functions regulatory mechanisms on properties PDAC. We investigate metabolite profiles by liquid chromatography-mass spectrometry...
Expression of recombinant proteins as fusions with SUMO (small ubiquitin-related modifier) protein has significantly increased the yield difficult-to-express in Escherichia coli. The benefit this technique is further enhanced by availability naturally occurring proteases, which remove from fusion protein. Here we have improved exiting approach for effective production native proteins. First, a sticky-end PCR strategy was applied to design new vector that allows directional cloning any target...
Significance Gefitinib is a small molecular inhibitor that targets EGFR tyrosine kinases (EGFR-TKI) and has been used as first-line treatment for advanced lung cancer. However, not all cancer patients respond to gefitinib treatment, resistance apparent who have undergone few months. We observed FOXO3a expression inversely correlated with responded poorly EGFR-TKI identified an underlying mechanism of in mutation-independent stemness through the epigenetic regulation NF-κB/miR-155. This...
HIF-1α, one of the most extensively studied oncogenes, is activated by a variety microenvironmental factors. The resulting biological effects are thought to depend on its transcriptional activity. RNAse enzyme Dicer frequently downregulated in human cancers, which has been functionally linked enhanced metastatic properties; however, current knowledge upstream mechanisms regulating limited. In present study, we identified as HIF-1α–interacting protein multiple types cancer cell lines and...
Abstract Glucagon-like peptide 1 receptor (GLP-1R) agonist is an emerging anti-diabetic medication whose effects on the risk and progression of cholangiocarcinoma (CCA) are controversial. This study aimed to elucidate roles GLP-1R its agonists intrahepatic CCA (iCCA) progression. Expressions in iCCA tissues investigated by immunohistochemistry showed that expressions were significantly associated with poor histological grading ( P = 0.027). cell lines, KKU-055 KKU-213A, treated exendin-4...
CARD-recruited membrane-associated protein 3 (CARMA3) is a novel scaffold that regulates nuclear factor (NF)-κB activation; however, the underlying mechanism of CARMA3 in lung cancer stemness and metastasis remains largely unknown.To investigate molecular mechanisms involvement non-small cell progression.The expression levels NME2 cohort patients with (n = 91) were examined by immunohistochemistry staining assessed Kaplan-Meier survival analysis. The effects CARMA3, microRNA-182 (miR-182),...
Esophageal cancer is an aggressive human malignancy with increasing incidence in the developed world. VEGF-C makes crucial contributions to esophageal progression that are not well understood. Here, we report discovery of regulatory relationship cancers between expression and cortactin (CTTN), a regulator cortical actin cytoskeleton. Upregulation CTTN by enhanced invasive properties squamous cell carcinoma vitro tumor metastasis vivo. Mechanistic investigations showed increased...
Hepatocellular carcinoma (HCC) is a lethal human malignancy and leading cause of cancer-related death worldwide. Patients with HCC are often diagnosed at an advanced stage, the prognosis usually poor. The multikinase inhibitor sorafenib first-line treatment for patients HCC. However, cases primary or acquired resistance to have gradually increased, predicament in therapy. Thus, it critical investigate mechanism underlying resistance. Transactivation response element RNA-binding protein 2...
The human intestine is a natural environment ecosystem of complex diversified and dynamic microorganisms, determined through process competition selection during life. Those intestinal microorganisms called microbiota are involved in variety mechanisms the organism, they interact with host therefore contact organs various systems. However, play crucial role maintaining homeostasis, also influencing its behaviour. Thus, perform series biological functions important for well-being. provides...
Breast cancer is the second leading cause of deaths in women worldwide and represents a highly aggressive nature with limited therapeutic options; thus, investigating novel agents for breast much needed. In this study, we investigated anticancer effects camptothecin derivative, CPT211, against human cancer. We used hormone receptor-positive MCF-7, triple-negative (TNBC) MDA-MB-231, HER2-positive BT-474 cells to examine cytotoxicity CPT211. measured cell viability dose dependence CPT211...
BACKGROUND AND PURPOSE As prognosis for patients with metastatic ovarian cancer is generally poor, advances in treatment are needed. Here, we studied the mechanism of action a recombinant viral capsid protein (rVP1) and explored its effect against tumour growth metastasis vivo . EXPERIMENTAL APPROACH The human cell line SKOV3 BALB/cAnN‐Foxn1 female nude mice were used. Effects rVP1 on viability, invasive ability, matrix metalloproteinase (MMP)‐2 activity proliferation determined by assay,...