A5101865212- Drug Transport and Resistance Mechanisms
- Pharmacological Effects and Toxicity Studies
- RNA modifications and cancer
- MicroRNA in disease regulation
- RNA Research and Splicing
- Liver Disease Diagnosis and Treatment
- Cholesterol and Lipid Metabolism
- Cancer-related molecular mechanisms research
- Pharmacogenetics and Drug Metabolism
- Antibiotics Pharmacokinetics and Efficacy
- Pediatric Hepatobiliary Diseases and Treatments
- Gout, Hyperuricemia, Uric Acid
- Hippo pathway signaling and YAP/TAZ
- DNA Repair Mechanisms
- Metabolism and Genetic Disorders
- Carcinogens and Genotoxicity Assessment
- Neonatal Health and Biochemistry
- Drug-Induced Hepatotoxicity and Protection
- RNA Interference and Gene Delivery
- Amino Acid Enzymes and Metabolism
- Alkaline Phosphatase Research Studies
- PARP inhibition in cancer therapy
- Cancer-related gene regulation
- Bone Metabolism and Diseases
- Cell death mechanisms and regulation
Nagoya University
1988-2025
The University of Tokyo
2010-2025
University of Tokyo Hospital
2015-2024
Astellas Pharma (Japan)
2008-2024
Gifu University
2023
Tokai National Higher Education and Research System
2023
National Institute for Fusion Science
2023
Japan Fisheries Research and Education Agency
2023
Obihiro University of Agriculture and Veterinary Medicine
2006-2022
Sakakibara Hospital
2020
Numerous immature thymocytes undergo apoptosis and are rapidly engulfed by phagocytic thymic macrophages. The macrophage surface receptors involved in apoptotic thymocyte recognition unknown. We have examined the role of class A scavenger receptor (SR-A) engulfment thymocytes. Uptake steroid-treated inflammatory-elicited SR-A positive macrophages is partially inhibited an anti-SR-A mAb more completely a range ligands. Thymic from mice with targeted disruption gene show 50% reduction...
Gout based on hyperuricemia is a common disease with genetic predisposition, which causes acute arthritis. The ABCG2/BCRP gene, located in gout-susceptibility locus chromosome 4q, has been identified by recent genome-wide association studies of serum uric acid concentrations and gout. Urate transport assays demonstrated that ABCG2 high-capacity urate secretion transporter. Sequencing the gene 90 patients revealed several nonfunctional mutations, including Q126X. Quantitative trait analysis...
Two types of cDNAs for human macrophage scavenger receptors were cloned from a cDNA library derived the phorbol ester-treated monocytic cell line THP-1. The type I and II encoded by these are homologous (73% 71% amino acid identity) to their previously characterized bovine counterparts consist six domains: cytoplasmic (I), membrane-spanning (II), spacer (III), alpha-helical coiled-coil (IV), collagen-like (V), type-specific C-terminal (VI). receptor gene is located on chromosome 8. expressed...
We previously reported that a forest bathing trip enhanced human NK activity, number of cells, and intracellular anti-cancer proteins in lymphocytes. In the present study, we investigated how long increased activity lasts compared effect on with to places city without forests. Twelve healthy male subjects, age 35–56 years, were selected informed consent. The subjects experienced three-day/two-night fields city, which levels during both trips matched. On day 1, walked for two hours afternoon...
Transforming growth factor-beta (TGF-beta) is a multifunctional cytokine that regulates cell growth, differentiation, and apoptosis of various types cells. Autophagy emerging as critical response normal cancer cells to environmental changes, but the relationship between TGF-beta signaling autophagy has been poorly understood. Here, we showed activates in human hepatocellular carcinoma lines. induced accumulation autophagosomes conversion microtubule-associated protein 1 light chain 3...
We have previously cloned rat MRP3 as an inducible transporter in the liver (Hirohashi, T., Suzuki, H., Ito, K., Ogawa, Kume, Shimizu, and Sugiyama, Y. (1998) Mol. Pharmacol. 53, 1068–1075). In present study, function of was investigated using membrane vesicles isolated from LLC-PK1 HeLa cell population transfected with corresponding cDNA. The ATP-dependent uptake both 17β estradiol 17-β-d-glucuronide ([3H]E217βG) glucuronide [14C] 6-hydroxy-5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)...
The mechanism for the cellular extrusion of sulfated conjugates is still unknown. In present study, we investigated whether human wild type ABCG2 transports estrone 3-sulfate (E1S) using membrane vesicles from cDNA-transfected mouse lymphoma cell line (P388 cells). uptake [3H]E1S into ABCG2-expressing was stimulated by ATP, and Km value determined to be 16.6 μm. ABCG2-mediated transport potently inhibited SN-38 many sulfate but not glucuronide glutathione or other anionic compounds. Other...
The aim of this study is to classify nonatherosclerotic aneurysms unrelated the branching zones (including fusiform and dissecting aneurysms).Damage internal elastic lamina (IEL) often an associated factor in pathogenesis aneurysm formation. In study, 85 arising from arterial trunk were classified into four different types, based on lesional patterns IEL state intima. Type 1 corresponded classic aneurysms, which was characterized by acute widespread disruption without intimal thickening....