A5015397484- Cholangiocarcinoma and Gallbladder Cancer Studies
- Metabolism, Diabetes, and Cancer
- Peptidase Inhibition and Analysis
- Pancreatic and Hepatic Oncology Research
- Cancer Mechanisms and Therapy
- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- Glycosylation and Glycoproteins Research
- Cancer-related Molecular Pathways
- Advanced Breast Cancer Therapies
- RNA modifications and cancer
- Cancer Immunotherapy and Biomarkers
- Mitochondrial Function and Pathology
- Nanoparticle-Based Drug Delivery
- Cytokine Signaling Pathways and Interactions
- Oral and gingival health research
- MicroRNA in disease regulation
- Drug Transport and Resistance Mechanisms
- Cancer Diagnosis and Treatment
- Epigenetics and DNA Methylation
- NF-κB Signaling Pathways
- Neuroendocrine Tumor Research Advances
- Glioma Diagnosis and Treatment
- Cancer-related cognitive impairment studies
- Berberine and alkaloids research
Khon Kaen University
2016-2025
Dana-Farber Cancer Institute
2020-2021
Harvard University
2020-2021
Baylor College of Medicine
2016-2020
Baylor Genetics
2016-2020
The ampulla of Vater is a complex cellular environment from which adenocarcinomas arise to form group histopathologically heterogenous tumors. To evaluate the molecular features these tumors, 98 ampullary were evaluated and compared 44 distal bile duct 18 duodenal adenocarcinomas. Genomic analyses revealed mutations in WNT signaling pathway among half patients all three irrespective their origin histological morphology. These tumors characterized by high frequency inactivating ELF3, rate...
Abstract Increased glucose utilization is a feature of cancer cells to support cell survival, proliferation, and metastasis. An association between diabetes mellitus progression was previously demonstrated in cancers including cholangiocarcinoma (CCA). This study aimed determine the effects high on protein O-GlcNAcylation metastatic potentials CCA cells. Two pairs each parental low highly sublines were cultured normal (5.6 mM) or (25 media. The migration invasion abilities determined...
Abstract Epidemiological studies have indicated diabetes mellitus (DM) as a risk of cholangiocarcinoma (CCA), however, the effects and mechanisms high glucose on progression CCA remain unclear. This study reports for first time enhancing aggressive phenotypes cells via STAT3 activation. cultured in media exerted significantly higher rates cell proliferation, adhesion, migration invasion than those normal glucose. The phosphokinase array revealed dominant signal activated response to...
Abstract Glucagon-like peptide 1 receptor (GLP-1R) agonist is an emerging anti-diabetic medication whose effects on the risk and progression of cholangiocarcinoma (CCA) are controversial. This study aimed to elucidate roles GLP-1R its agonists intrahepatic CCA (iCCA) progression. Expressions in iCCA tissues investigated by immunohistochemistry showed that expressions were significantly associated with poor histological grading ( P = 0.027). cell lines, KKU-055 KKU-213A, treated exendin-4...
Cholangiocarcinoma (CCA) is an aggressive cancer for which standard treatments are still ineffective. This study demonstrated the antiproliferative and anti-metastatic activity of metformin, anti-diabetic drug, in CCA cells.Cell proliferation, migration/invasion anoikis resistance were determined. The underlying mechanisms identified using western blotting immunocytofluorescence.Metformin significantly suppressed proliferation cells a dose- time-dependent manner, regardless glucose present...
Alteration of glycosylation in cancer cells leads to the expression tumor-associated glycans, which can be used as biomarkers for diagnosis and prognostic prediction diseases. In this study, we nano-LC-QToF identify serum N-glycan detection brain tumors. We observed an increase sialylated N-glycans a decrease fucosylated patients with glioblastoma (GBM) meningioma (MG) compared healthy individuals. GBM, combination increased (6_4_0_2 compound) decreased (4_4_1_0 was identified most...
The roles of γ-aminobutyric acid (GABA) and its receptors in lung cancer development progression remain controversial. This study aimed to investigate the effects activating GABA receptor type B (GABA-B receptor) using baclofen, a GABA-B agonist, on proliferation adenocarcinoma cells underlying mechanisms. Differential expression was analyzed online Gene Expression Profiling Interactive Analysis tool. Lung cell lines, A549 PC-9, were cultured RPMI-1640 medium used for vitro experiments....
The human intestine is a natural environment ecosystem of complex diversified and dynamic microorganisms, determined through process competition selection during life. Those intestinal microorganisms called microbiota are involved in variety mechanisms the organism, they interact with host therefore contact organs various systems. However, play crucial role maintaining homeostasis, also influencing its behaviour. Thus, perform series biological functions important for well-being. provides...
Cancer immunotherapy has emerged as a groundbreaking field, offering promising and transformative tools for oncological research treatment. However, it faces several limitations, including variations in cancer types, dependence on the tumor microenvironments (TMEs), immune cell exhaustion, adverse reactions. Magnetic nanoparticles, particularly magnetite nanoparticles (MNPs), with established pharmacodynamics pharmacokinetics clinical use, hold great promise this context are now being...
Dicer is an enzyme that processes microRNAs (miRNAs) precursors into mature miRNAs, which have been implicated in various aspects of cancer progressions, such as clinical aggressiveness, prognosis, and survival outcomes. We previously showed high expression associated with gemcitabine (GEM) resistance pancreatic ductal adenocarcinoma (PDAC); thus, this study, we aimed to focus on how involved GEM PDAC, including cell proliferation, metabolic regulation.We generated stable shRNA knockdown...
Diabetes mellitus (DM) is an established risk for hepatocellular carcinoma (HCC), with unclarified mechanisms. This study investigated the effects of hyperglycemia on O-GlcNacylation in hepatocytes and its associations hepatocarcinogenesis.Mouse human HCC cell lines were used vitro model hyperglycemia. Western blotting was to determine high glucose cells. Twenty 4-week-old C3H/HeNJcl mice randomized into four groups: non-DM control, plus diethylnitrosamine (DEN), DM, DM DEN. induced using...
Background: Hepatocellular carcinoma (HCC) is the most prevalent primary liver cancer. Anomianthus dulcis (Dunal) J.Sinclair (syn. Uvaria dulcis) has been used in Thai traditional medicine various therapeutic indications. Phytochemical constituents of A. have isolated and identified. However, their effects on cancer associated mechanisms not elucidated. Methods: Dry flowers were extracted using organic solvents, chromatographic methods to purify secondary metabolites. The chemical structures...