A5060855417- Viral Infections and Vectors
- Mosquito-borne diseases and control
- Immune Cell Function and Interaction
- Lymphoma Diagnosis and Treatment
- Malaria Research and Control
- Cancer Immunotherapy and Biomarkers
- Virus-based gene therapy research
- Animal Disease Management and Epidemiology
- Chronic Lymphocytic Leukemia Research
- Viral Infections and Outbreaks Research
- Peptidase Inhibition and Analysis
- Nanoparticle-Based Drug Delivery
- Viral-associated cancers and disorders
- HIV/AIDS drug development and treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Monoclonal and Polyclonal Antibodies Research
- Chemokine receptors and signaling
- Nanoplatforms for cancer theranostics
- Cancer Diagnosis and Treatment
- Vector-borne infectious diseases
- Cancer therapeutics and mechanisms
- Gastric Cancer Management and Outcomes
- T-cell and B-cell Immunology
- Vector-Borne Animal Diseases
- Cytomegalovirus and herpesvirus research
Harvard University
2022-2024
Kumamoto University
2019-2024
Dana-Farber Cancer Institute
2022-2024
Boston University
2024
Khon Kaen University
2023
Mahidol University
2012-2019
Siriraj Hospital
2012-2019
Dengue virus (DENV) infection causes organ injuries, and the liver is one of most important sites DENV infection, where viral replication generates a high load. The molecular mechanism DENV-induced injury still under investigation. mitogen activated protein kinases (MAPKs), including p38 MAPK, have roles in hepatic cell apoptosis induced by DENV. However, vivo role MAPK not fully understood. In this study, we investigated SB203580, inhibitor, mouse model infection. Both hematological...
Cholangiocarcinoma (CCA) presents a significant clinical challenge which is often identified in advanced stages, therby restricting the effectiveness of surgical interventions for most patients. The high incidence cancer recurrence and resistance to chemotherapy further contribute bleak prognosis low survival rates. To address this pressing need effective therapeutic strategies, our study focuses on development an innovative cellular immunotherapy, specifically utilizing chimeric antigen...
Primary effusion lymphoma (PEL) is a large B-cell neoplasm usually presenting as serious in body cavities without detectable tumor masses. It an AIDS-related non-Hodgkin’s (HL) with human herpes virus 8 (HHV8)/Kaposi sarcoma-associated (KSHV) infection. A combination antiretroviral therapy (cART) prolongs the lifespan of AIDS and malignant patients, but PEL continues to have dismal prognosis. showed disappointing outcomes standard chemotherapy such CHOP or CHOP-like regimens. status...
Recent studies have revealed that tissue macrophages are derived from yolk sac precursors or fetal liver monocytes, in addition to bone marrow monocytes. The relative contribution of these cells the macrophage pool is not fully understood, but embryo-derived supposed be more important because their capacity self-renew. Here, we show presence adult marrow-derived retain self-renewing capacity. were readily obtained by long-term culture mouse with colony-stimulating factor (M-CSF), a key...
Cancer immunotherapy has emerged as a groundbreaking field, offering promising and transformative tools for oncological research treatment. However, it faces several limitations, including variations in cancer types, dependence on the tumor microenvironments (TMEs), immune cell exhaustion, adverse reactions. Magnetic nanoparticles, particularly magnetite nanoparticles (MNPs), with established pharmacodynamics pharmacokinetics clinical use, hold great promise this context are now being...
Dengue virus (DENV) infection is a public health problem in tropical and subtropical regions. It can cause spectrum of clinical manifestations ranging from mild dengue fever (DF) to severe haemorrhagic (DHF) potentially life-threatening disease including shock syndrome (DSS). Severe DENV caused by high viral load cytokine storm dengue-infected patients. Currently, there no specific antiviral drug for infection. An anti-DENV agent that demonstrates inhibitory effects on both replication...
Objective: Nude mice are used as a recipient for human tumor cell xenografts. However, the success rate of xenotransplantation is unsatisfactory due to high natural killer (NK) activity. To overcome this limitation, we established nude with no NK cells, and compared transplantation efficiency that in mice. Methods: BALB/c Jak3-/- (Nude-J) were by crossing Jak-3-/- Hematopoietic malignant lines (BCBL-1 Z138) implanted subcutaneously compare tumorigenicity Nude-J Rag-2/Jak3 double deficient...
Human T-cell leukemia virus type 1 (HTLV-1) infects target cells primarily through cell-to-cell routes. Here, we provide evidence that cellular protein M-Sec plays a critical role in this process. When purified and briefly cultured, CD4 + T of HTLV-1 carriers, but not - individuals, expressed M-Sec. The viral Tax was revealed to mediate induction. Knockdown or pharmacological inhibition reduced infection multiple co-culture conditions. Furthermore, knockdown the number proviral copies...
In this study, the effect of innate serum inhibitors on influenza virus infection was addressed. Seasonal A(H1N1) and A(H3N2), 2009 pandemic (H1N1pdm) highly pathogenic avian (HPAI) A(H5N1) viruses were tested with guinea pig sera negative for antibodies against all these as evaluated by hemagglutination-inhibition microneutralization assays. presence inhibitors, each inhibited differently measured amount viral nucleoprotein produced in Madin-Darby canine kidney cells. The seasonal A(H3N2)...
Background/Aim: Primary effusion lymphoma (PEL) is a rare aggressive B-cell associated with HHV-8. With median survival of fewer than six months, the prognosis disease current standard therapies usually dismal. Dihydroartemisinin (DHA) derivative artemisinin, originally designed as an antimalarial drug. Several studies have shown that this compound also demonstrates anti-cancer activity in various types cancer, including hematologic malignancies. Materials and Methods: Anti-proliferation DHA...
HIV-1 persists during antiretroviral therapy (ART) due to long-lived and proliferating latently-infected host cells, with the outcome being an incomplete cure. The or reservoir are transcriptionally absent invisible immune response. Elimination of latency is one strategy in activating virus production, making it visible clearance. We previously showed that Ephedrae herba reactivated from latency. In this study, we used ephedrine, a major component Ephedra herba, reactivate results ephedrine...
Background: Diabetes mellitus (DM) is associated with the increased risk of development and advancement cholangiocarcinoma (CCA). High glucose levels were previously shown for upregulating interleukin-1β (IL-1β) in CCA cells unclear functions. The present study, thus, aimed to investigate molecular mechanisms linking DM progression, IL-1β hypothesized as a communicating cytokine. Methods: cultured media normal (5.6 mM) or high (25 glucose, resembling euglycemia hyperglycemia, respectively....
Soft tissue and bone tumors are rare, their low frequency diverse histological types make conducting large-scale clinical trials challenging. Patient-derived xenografts (PDX), entailing implantation of cancer specimens in immunocompromised mice, emerging as a valuable translational model because PDX keeps the original tumors' character drug sensitivity. We sequentially transplanted 166 surgical biopsy from orthopedic surgeries, including 138 soft (81 malignant, 23 intermediate, 34 benign),...