A5009328108- Mosquito-borne diseases and control
- CAR-T cell therapy research
- Immunotherapy and Immune Responses
- Viral Infections and Vectors
- Ion Transport and Channel Regulation
- Pancreatic function and diabetes
- Cancer Immunotherapy and Biomarkers
- Erythrocyte Function and Pathophysiology
- Malaria Research and Control
- Diabetes and associated disorders
- Biomedical Research and Pathophysiology
- Immune Cell Function and Interaction
- Neonatal Health and Biochemistry
- Viral Infections and Outbreaks Research
- Kidney Stones and Urolithiasis Treatments
- Ion channel regulation and function
- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Nanowire Synthesis and Applications
- Endoplasmic Reticulum Stress and Disease
- Metabolism, Diabetes, and Cancer
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Insect symbiosis and bacterial influences
- Genetic and Kidney Cyst Diseases
- RNA modifications and cancer
Siriraj Hospital
2016-2025
Mahidol University
2016-2025
Institute of Molecular Medicine
2014
University College London
2012
Christian Medical College & Hospital
2012
Thammasat University
2012
Bristol Institute for Transfusion Sciences
2012
University of Bristol
2012
Chulalongkorn University
2012
NHS Blood and Transplant
2012
Vascular leakage and shock are the major causes of death in patients with dengue hemorrhagic fever (DHF) syndrome (DSS). Thirty years ago, complement activation was proposed to be a key underlying event, but cause has remained unknown.The nonstructural virus (DV) protein NS1 tested for its capacity activate human membrane-associated soluble forms. Plasma samples from 163 DV infection 19 other febrile illnesses were prospectively analyzed viral load levels complement-activation products....
Context: Six maturity onset diabetes of the young (MODY) genes have been discovered to date but account for a small proportion MODY among Asians, suggesting existence other in this racial group.
Abstract Background Carcinoma-associated fibroblasts (CAFs) play a critical role in cancer progression and immune cell modulation. In this study, it was aimed to evaluate the roles of CAFs-derived IL-6 doxorubicin (Dox) resistance PD-L1-mediated chimeric antigenic receptor (CAR)-T breast (BCA). Methods CAF conditioned-media (CM) were collected, level measured by ELISA. CAF-CM treated MDA-MB-231 HCC70 TNBC lines si (IL-6R) knocked down (KD) cells determine effect CAF-derived on Dox flow...
Dengue virus (DENV) infection causes organ injuries, and the liver is one of most important sites DENV infection, where viral replication generates a high load. The molecular mechanism DENV-induced injury still under investigation. mitogen activated protein kinases (MAPKs), including p38 MAPK, have roles in hepatic cell apoptosis induced by DENV. However, vivo role MAPK not fully understood. In this study, we investigated SB203580, inhibitor, mouse model infection. Both hematological...
Tumor escapes host immune responses by producing immunosuppressive cytokines, such as IL-10 and TGF-β, secreted into the tumor microenvironment. These cytokines play important roles in suppression of dendritic cell (DC) function, leading to decreased effector CD4+ CD8+ T cells. To improve DC functions enhance cytolytic activity activated T-cells, we suppressed effect these on DCs using specific neutralizing antibodies that inhibit TGF-β receptors. Monocyte-derived generated vitro showed...
Current treatments for cholangiocarcinoma (CCA) are largely unsuccessful due to late diagnosis at advanced stage, leading high mortality rate. Consequently, improved therapeutic approaches urgently needed. Chimeric antigen receptor (CAR) T cell therapy is a newly potential that can recognize specific surface without major histocompatibility complex (MHC) restriction. Mucin 1 (MUC1) an attractive candidate as it highly expressed and associated with poor prognosis survival in CCA. We,...
Cholangiocarcinoma (CCA) presents a significant clinical challenge which is often identified in advanced stages, therby restricting the effectiveness of surgical interventions for most patients. The high incidence cancer recurrence and resistance to chemotherapy further contribute bleak prognosis low survival rates. To address this pressing need effective therapeutic strategies, our study focuses on development an innovative cellular immunotherapy, specifically utilizing chimeric antigen...
Dengue virus (DENV) infection causes mild to severe illness in humans that can lead fatality cases. Currently, no specific drug is available for the treatment of DENV infection. Thus, development an anti-DENV urgently required. Cordycepin (3′-deoxyadenosine), which a major bioactive compound Cordyceps (ascomycete) fungus has been used centuries Chinese traditional medicine, was reported exhibit antiviral activity. However, activity cordycepin unknown. We hypothesized exerts and that, as...
Cholangiocarcinoma (CCA) is a lethal bile duct cancer that responds poorly to current standard treatments. A new therapeutic approach is, therefore, urgently needed. Adoptive T cell transfer using chimeric antigen receptor (CAR) cells modality with demonstrated efficacy in hematologic malignancies. However, its against solid tumors modest, and further intensive investigation continues. An important factor influences the success of CAR therapy selection target highly expressed on cells, but...
Abstract Cholangiocarcinoma (CCA) is a lethal cancer with rapid progression and poor survival. Novel more effective therapies than those currently available are, therefore, urgently needed. Our research group previously reported the combination of gemcitabine cytotoxic T lymphocytes to be single-agent treatment for elimination CCA cells. However, cells upregulates expression an immune checkpoint protein (programmed death-ligand 1 [PD-L1]) that consequently inhibits cytotoxicity lymphocytes....
Cancer is the leading cause of death worldwide. Drug resistance and relapse after current standard treatments frequently occur; thus, alternative effective are required. Algae cyanobacteria abundant organisms that serve as bioresources nutrients/metabolites, which attractive sources numerous bioactive compounds for drug discovery. In present study, we, therefore, investigated anti-cancer activities crude polysaccharide ethanolic extracts from Chlorella sp., Sargassum spp., Spirulina sp....
The treatment of breast cancer (BC) remains a formidable challenge due to the emergence drug resistance, necessitating exploration innovative strategies. Chimeric antigen receptor (CAR)-T cell therapy, groundbreaking approach in hematologic malignancies, is actively under investigation for its potential application solid tumors, including BC. Trophoblast surface 2 (Trop2) has emerged as promising immunotherapeutic target various cancers and notably overexpressed To enhance therapeutic...
Mutations in SLC4A1, encoding the chloride-bicarbonate exchanger AE1, cause distal renal tubular acidosis (dRTA), a disease of defective urinary acidification by nephron. In this study we report novel missense mutation, G609R, causing dominant dRTA affected members large Caucasian pedigree who all exhibited metabolic with alkaline urine, prominent nephrocalcinosis, and progressive impairment. To investigate potential mechanism, consequent effects mutation were determined. We first assessed...
Distal renal tubular acidosis (dRTA), a kidney disease resulting in defective urinary acidification, can be caused by dominant or recessive mutations the Cl – /HCO 3 anion exchanger (kAE1), glycoprotein expressed basolateral membrane of α‐intercalated cells. We compared effect two (R589H and S613F) (S773P G701D) dRTA point on kAE1 trafficking Madin‐Darby canine (MDCK) epithelial In contrast to wild‐type (WT) that was localized membrane, mutants (kAE1 R589H were retained endoplasmic reticulum...