A5027475577- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Fuel Cells and Related Materials
- Protein Structure and Dynamics
- Crystallography and molecular interactions
- Monoclonal and Polyclonal Antibodies Research
- Conducting polymers and applications
- Metal-Organic Frameworks: Synthesis and Applications
- Natural product bioactivities and synthesis
- Computational Drug Discovery Methods
- Advanced Polymer Synthesis and Characterization
- Bacteriophages and microbial interactions
- Polymer crystallization and properties
- HIV Research and Treatment
- Drug Transport and Resistance Mechanisms
- Block Copolymer Self-Assembly
- Analytical Chemistry and Chromatography
- Ion-surface interactions and analysis
- HIV/AIDS drug development and treatment
- Mass Spectrometry Techniques and Applications
- Signaling Pathways in Disease
- Ferroelectric and Piezoelectric Materials
- Galectins and Cancer Biology
- Plasma Applications and Diagnostics
- Ionic liquids properties and applications
Chiang Mai University
2016-2025
Thailand Center of Excellence in Physics
2010-2024
Mahidol University
2002-2022
Toyota Technological Institute
2006
Osaka University
2002-2003
Zirconia ceramics have been widely used as dental restorations due to their esthetic appearance and high flexural strength. The bonding of zirconia with resin cement should rely on both mechanical chemical bonds. This study was performed investigate the effect surface topography its wettability after pretreatments microshear bond strength (μSBS) a cement. slabs were prepared randomly divided into 5 groups based treatment follows: no (control), air abrasion (AB), etching hydrofluoric acid...
The major obstacle in using CO2 the cycloaddition reactions with epoxides can be subdued through use of high performance catalysts particularly those efficient at or near ambient temperature and pressure. Performances heterogeneous are, however, subpar compared to homogeneous counterparts although being preferable from practical viewpoint. Heterometallic 3d-4f coordination polymers have offered best opportunity date their possible performances is not yet achieved. Through rational...
Family 18 chitinases catalyze the hydrolysis of β-1,4-glycosidic bonds in chitin. The mechanism has been proposed to involve formation an oxazolinium ion intermediate via unusual substrate-assisted mechanism, which substrate itself acts as intramolecular nucleophile (instead enzyme residue). Here, we have modeled first step chitin catalyzed by Serratia marcescens chitinase B for time using a combined quantum mechanics/molecular mechanics approach. calculated reaction barriers based on...
Dengue virus (DENV) infection causes mild to severe illness in humans that can lead fatality cases. Currently, no specific drug is available for the treatment of DENV infection. Thus, development an anti-DENV urgently required. Cordycepin (3′-deoxyadenosine), which a major bioactive compound Cordyceps (ascomycete) fungus has been used centuries Chinese traditional medicine, was reported exhibit antiviral activity. However, activity cordycepin unknown. We hypothesized exerts and that, as...
Abstract Cholangiocarcinoma (CCA) is a lethal cancer with rapid progression and poor survival. Novel more effective therapies than those currently available are, therefore, urgently needed. Our research group previously reported the combination of gemcitabine cytotoxic T lymphocytes to be single-agent treatment for elimination CCA cells. However, cells upregulates expression an immune checkpoint protein (programmed death-ligand 1 [PD-L1]) that consequently inhibits cytotoxicity lymphocytes....
Accurate binding affinities of the cucurbit-7-uril-gemcitabine (CB7-GEM) complex in pure water and ethanol/water-mixed solvents were obtained by combining molecular dynamics simulations three-dimensional reference interaction site model (3D-RISM) calculations. Point charges CB7 GEM molecules, depending on solvent mixture ratios, determined using 3D-RISM self-consistent field (3D-RISM-SCF) The calculated reveal that most preferable CB7-GEM forms system. complexes mixed show lower stability at...
Tyrosinase is a key enzyme in melanogenesis. Generally, mushroom tyrosinase from A. bisporus had been used as model skin-whitening agent tests employed the cosmetic industry. The recently obtained crystal structure of bacterial B. megaterium has high similarity (33.5%) to human and thus it was template for constructing model. Binding series its inhibitors simulated by automated docking calculations. Docking MD simulation results suggested that N81, N260, H263, M280 are involved binding...
Surface modification of silica-coated magnesium ferrite nanoparticles (MgFe2O4@SiO2 NPs) by 3-aminopropyltriethoxysilane (APTES) shows enhanced selectivity for the removal Congo Red (CR) from both single and binary aqueous dye solutions. Before coating surfaces amine-functionalized (MgFe2O4–NH2 with silica, control studies adsorption cationic, neutral, anionic dyes were performed using systems. The found that MgFe2O4–NH2 nanoadsorbent favors indigo carmine (IC) CR in solutions (>90%...
Among the total of 146 volatiles extracted by SPME from headspace some black and white rice bran samples, twenty-eight terpenoid odorants were acculately identified. Most these terpenoids possess good aroma character are varied among three groups Thai rice; glutinous, non-glutinous, non-glutinous. Of groups, non-glutinous contains greater number monoterpenoids. However, content major odorants, which limonene, trans-β-ocimene, β-cymene, linalool, is highest in jasmine rice, Khao Dawk Mali 105...
Protein-protein interaction plays an essential role in almost all cellular processes and biological functions. Coupling molecular dynamics (MD) simulations nanoparticle tracking analysis (NTA) assay offered a simple, rapid, direct approach monitoring the protein-protein binding process predicting affinity. Our case study of designed ankyrin repeats proteins (DARPins)—AnkGAG1D4 single point mutated AnkGAG1D4-Y56A for HIV-1 capsid protein (CA) were investigated. As reported, AnkGAG1D4 bound...
Phosphodiesterase 1B (PDE1B) and PDE10A are dual-specificity PDEs that hydrolyse both cyclic adenosine monophosphate guanosine monophosphate, highly expressed in the striatum. Several reports have suggested inhibitors may present a promising approach for treatment of positive symptoms schizophrenia, whereas PDE1B novel mechanism to modulate cognitive deficits. Previously, we reported dual inhibitor PDE10A, compound 2...
Molecular and crystal structures of a series model compounds poly(m-phenylene isophthalamide) have been analyzed by the X-ray diffraction method various types 3-D hydrogen bond network clarified. The twisting angles between benzene amide groups are in range 25−40°, which is common to all parent polymer itself could be reproduced well energy calculation with nonbonded interatomic interactions taken into consideration. molecular conformation, packing mode molecules, intermolecular structure...
In this work, molecular docking, pharmacophore modeling and dynamics (MD) simulation were rendered for the mouse P-glycoprotein (P-gp) (code: 4Q9H) bioflavonoids; amorphigenin, chrysin, epigallocatechin, formononetin rotenone including a positive control; verapamil to identify protein-ligand interaction features binding affinities, characteristics, hot-spot amino acid residues complex stabilities. These flavonoids occupied same site with high affinities shared key their interactions region...
Crystal structure of a three-arm model compound poly(m-phenylene isophthalamide) (PMIA), N,N',N' '-triphenyl trimesamide Phi(CONHPhi)(3), has been analyzed by the X-ray diffraction method. The torsional angles around bonds connecting amide group and central benzene ring are 24-34 degrees , almost same as those observed for many kinds aromatic compounds, reflecting mainly intramolecular energetic balance between groups. On other hand, outer were found to distribute over wide range 2-51 due...