Abstract Aim To compare the outcome of partial pulpotomy using two cements, ProRoot MTA (Dentsply, Tulsa Dental Specialties, Tulsa, OK, USA) and Biodentine (Septodont, Saint‐Maur‐des‐Fossés, France), in permanent teeth 6‐ to 18‐year‐old patients with signs symptoms indicative irreversible pulpitis. Furthermore, frequencies perceptible grey discoloration caused by cements were compared. Methodology Sixty‐nine first molars pulpitis, from 69 patients, included. All operators performed under a...

Zirconia ceramics have been widely used as dental restorations due to their esthetic appearance and high flexural strength. The bonding of zirconia with resin cement should rely on both mechanical chemical bonds. This study was performed investigate the effect surface topography its wettability after pretreatments microshear bond strength (μSBS) a cement. slabs were prepared randomly divided into 5 groups based treatment follows: no (control), air abrasion (AB), etching hydrofluoric acid...

Probiotic supplementation can reduce mutans streptococci (MS) numbers. One of its proposed mechanisms is immunomodulation. Salivary human neutrophil peptide 1-3 (HNP1-3) levels have previously been demonstrated to be higher in caries-free than caries-susceptible children, suggesting their preventive role against caries. We aimed compare salivary HNP1-3 between an intervention group with probiotics and a control group.A randomized double-blinded clinical trial was conducted. Sixty...

Immediate dental implant loading has been investigated with favorable results. However, short implants have not in this treatment option. This study compared the clinical outcomes and survival rates of immediately loaded conventional length replacing mandibular molar teeth.Forty-six (23 23 implants) 46 patients were included study. Provisional computer-aided design/computer-aided manufacturing (CAD/CAM) ceramic crowns cemented to abutments loaded. Several parameters recorded statistically...

Corydalis plants containing isoquinoline alkaloids are reported to possess promising phamacological properties for the treatment of important diseases including cancer, inflammation, Alzheimer's disease and microbial infections. As part a wider program investigating Bhutanese medicinal plants,.we have previously identified eight from C. dubia. Out these, we report here on two major alkaloids, scoulerine (1) cheilanthifoline (2) their inhibitory activities against acetylcholinesterase...

Three known compounds, stemofoline (1), (2'S)-hydroxystemofoline (2), and (11Z)-1',2'-didehydrostemofoline (3), along with two new alkaloids, stemaphylline (4) stemaphylline-N-oxide (5), have been isolated from a root extract of Stemona aphylla. The structures these alkaloids were determined on the basis their spectroscopic data. analysis crude dichloromethane by GC-MS in EIMS mode showed presence 1-4, alkaloid 11, stilbostemin R (12). 4 tested for comparative biological activities. results...

A new stemofoline alkaloid, (2′S)-hydroxy-(11S,12R)-dihydrostemofoline (3), stemofurans M−R (8−13), and known compounds (1), (2′S)-hydroxystemofoline (2), stemofuran E (4), F (5), J (6), stilbostemin (7) have been isolated from the root extracts of Stemona aphylla. The structures relative configurations these determined by spectroscopic data interpretation semisynthetic studies. These natural alkaloids were tested for acetylcholinesterase inhibitory activities found to be 10−20 times less...

Semisynthesis of the known Stemona alkaloids oxystemofoline (7) and methoxystemofoline (8) has been achieved starting from (11Z)-1',2'-didehydrostemofoline (6), which confirmed their structures absolute configurations. The synthesis (1'R)-hydroxystemofoline (9) helped establish this compound as a natural product aphylla. (1'S)-Hydroxystemofoline (10) number related analogues were also prepared. In TLC bioautographic assay, 9 was found to be most active acetylcholinesterase inhibitor, but it...

The chemical constituents and biological activities of Corydalis crispa (Fumariaceae) were investigated for the first time. phytochemical study resulted in isolation nine known isoquinoline alkaloids: protopine (1), 13-oxoprotopine (2), 13-oxocryptopine (3), stylopine (4), coreximine (5), rheagenine (6), ochrobirine (7), sibiricine (8) bicuculline (9), with complete NMR data 2 3 provided here Crude extracts exhibitedsignificant anti-inflammatory (p < 0.01) activity against TNF-alpha...

Abstract Background/Aim Tooth avulsion causes an injury to the periodontal ligament (PDL). The success of tooth replantation depends on quantity and quality PDL cells. aim this study was examine preservative proliferative effects Thai propolis extract, previously shown exert anti‐inflammatory antioxidant activities, human Materials methods Ninety‐six premolars were left air dry for 30 min stored in Hank's balanced salt solution (HBSS), milk, or various concentrations extract from 0.25 10 mg...

The semisynthesis of the Stemona alkaloids (3′R)-stemofolenol (1), (3′S)-stemofolenol (2), methylstemofoline (3), and (3′S)-hydroxystemofoline (5) unnatural analogues (11E)-methylstemofoline (15) 3′R-hydroxystemofoline (11) has been achieved starting from (11Z)-1′,2′-didehydrostemofoline (4). This synthesis allowed, for first time, access to diastereomerically enriched samples 1 2 assignment their absolute configurations at C-3′. These compounds were obtained in sufficient quantities allow...

The objective of this study was to evaluate and compare the accuracy image quality root surface area (RSA) measurements obtained with various cone-beam computed tomography (CBCT) protocols, relative gold standard micro-computed (CT), in an

Six new stemofoline alkaloids, (2'R)-hydroxystemofoline (5), (3'R)-stemofolenol (6), (3'S)-stemofolenol (7), 1',2'-didehydrostemofoline-N-oxide (8), the first C19 alkaloid, methylstemofoline (9), and glycosidated Stemona stemofolinoside (10), three known (2'S)-hydroxystemofoline (2), (11Z)-1',2'-didehydrostemofoline (3), (11E)-1',2'-didehydrostemofoline (4), have been isolated from a root extract of an unidentified species. The structure relative configuration these alkaloids determined by...

The isolation of two new Stemona alkaloids, 1-hydroxyprotostemonine and stemocurtisine N-oxide, a benzofuran, stemofuran L, from the root extracts curtisii is reported. major known alkaloids this plant extract, stemocurtisine, stemocurtisinol, oxyprotostemonine, were also isolated along with oxystemokerrine N-oxide. nonalkaloid components extract included benzofuran derivative, stemofurans F, J, K, dihydro-γ-tocopherol, stigmasterol. Stemocurtisine stemocurtisinol converted to their...

Resistance to chemotherapy in cancer patients has been correlated the overexpression of ATP-binding cassette (ABC) drug transporters including P-glycoprotein (P-gp) that actively efflux chemotherapeutic drugs from cells. We examined mutidrug resistance reversing property stemofoline derivatives drug-resistance human cervical carcinoma (KB-V1) and leukemic (K562/Adr) cell lines overexpress P-gp. Didehydrostemofoline eleven its were synthesized cytotoxicity their effect on doxorubicin,...

The purpose of this study was to compare two biochemical markers, which have been previously used determine the degrees alveolar bone destruction, in evaluating periodontal disease severity. WF6 epitope chondroitin sulfate (CS) and alkaline phosphatase (ALP) levels were determined gingival crevicular fluid (GCF) samples collected from patients with various severity, including ten gingivitis (50 sites) 33 chronic periodontitis (including gingivitis, slight, moderate, severe sites; n = 50...

Although some studies have shown induction of cyclooxygenase 2 (COX-2) in oral lichen planus (OLP), an association between COX-2 upregulation and OLP clinical severity has not been investigated. Therefore, we aimed to compare expression with that normal tissues, determine correlations both criteria visual analog scale (VAS) scores.COX-2 was studied 25 13 tissues by immunohistochemistry. Both VAS scores were used evaluate the OLP. The differences determined nonparametric statistical...

This study aimed to determine expressions of methyltransferase-like 3 (METTL3) and METTL14, two enzymes essential for mRNA methylation at the adenosine (m6 A), in oral squamous cell carcinoma (OSCC) investigate vitro aggressiveness their aberrant expressions.METTL3 METTL14 50 OSCC 11 normal tissues were examined by immunohistochemistry. METTL3 m6 A amounts determined three lines, including HN5, HN6, HN15. Cell proliferation, migration, invasion studied BrdU, wound healing, Transwell chamber...

This study aimed to investigate the effect of heat-based obturation technique on push-out bond strength classical bioceramic and new HiFlow sealer. Fifty single-rooted human mandibular premolars were obturated using one following techniques: (1) BC-SC; (2) BC-W; (3) HiFlow-SC; (4) HiFlow-W; (5) AH Plus-W. Following obturation, specimens sectioned into 1-mm-thick root slices 4 8 mm from working length subjected a test universal testing machine examined for their modes failure under an...