Abstract Numerous studies suggest that modification with functional nanomaterials can enhance the electrode electrocatalytic activity, sensitivity, and selectivity of electrochemical sensors. Here, a highly sensitive cost-effective disposable non-enzymatic glucose sensor based on copper(II)/reduced graphene oxide modified screen-printed carbon is demonstrated. Facile fabrication developed sensing electrodes carried out by adsorption copper(II) onto electrode, then following reduction. The...

Kaempferia parviflora (KP) is an herb found in the north of Thailand and used as a folk medicine for improving vitality. Current reports have shown anti-cancer activities KP. However, effects KP on highly aggressive ovarian cancer not been investigated. Therefore, we determined cell proliferation, migration, death SKOV3 cells. Ovarian line, was to investigate effect extract. Cell viability, MMP activity, invasion were measured by MTT assay, counting, gelatin zymography, wound healing...

Kaempferia parviflora (KP) has been used as folk medicine for curing various conditions, including anti-inflammatory diseases. However, anti-psoriatic effects in an aspect of suppression NF-κB activation have not explored. Therefore, our current study aimed to elucidate the anti-inflammation KP lipopolysaccharide (LPS)-induced RAW264.7 cells and cytokine-induced human keratinocytes, HaCaT cells. We discovered that extract significantly suppressed LPS-induced inflammation at both gene...

Kaempferia parviflora (KP) has been traditionally used as a folk remedy to treat several diseases including cancer, and studies have reported cytotoxic activities of extracts KP against number different cancer cell lines. However, many aspects the molecular mechanism action remain unclear. In particular, ability regulate growth survival signaling is still largely unexplored. The current study aimed investigate effects on viability, migration, invasion, apoptosis, pathways related cervical...

Kaempferia parviflora (KP) has been reported to have anti-cancer activities. We previously its effects against cervical cancer cells and continued elucidate the of KP on inhibiting production secretion interleukin (IL)-6, as well relevant signaling pathways involved in tumorigenesis. discovered that suppressed epidermal growth factor (EGF)-induced IL-6 HeLa cells, it was associated with a reduced level Glycoprotein 130 (GP130), phosphorylated signal transducers activators transcription 3...

Light management allows enhancement of light harvesting in organic solar cells (OSCs). In this paper, we describe the investigation OSCs enhanced by synergistic effect gold quantum dots (AuQDs) and localized surface plasmons, obtained blending a AuQD layer plasmonic nanoparticles (AuNPs) hole-transport (HTL). Different AuQDs emitting blue, green, red fluorescence were examined study. The demonstrated to comprise an ITO-coated glass substrate/AuQDs/PEDOT:PSS:AuNPs/P3HT:PCBM/Al structure....

A new pentacyclic Stemona alkaloid, stemocurtisinol (3), with a pyrido[1,2-a]azepine A,B-ring system, and the known pyrrolo[1,2-a]azepine alkaloid oxyprotostemonine (4) have been isolated from root extract of S. curtisii. The structure relative stereochemistry was determined by spectral data interpretation X-ray crystallography. This compound is diastereoisomer oxystemokerrin has opposite configuration at C-4 C-19. individual components showed significant larvicidal activity (IC50 4−39 ppm)...

Three known compounds, stemofoline (1), (2'S)-hydroxystemofoline (2), and (11Z)-1',2'-didehydrostemofoline (3), along with two new alkaloids, stemaphylline (4) stemaphylline-N-oxide (5), have been isolated from a root extract of Stemona aphylla. The structures these alkaloids were determined on the basis their spectroscopic data. analysis crude dichloromethane by GC-MS in EIMS mode showed presence 1-4, alkaloid 11, stilbostemin R (12). 4 tested for comparative biological activities. results...

A new pentacyclic stemona alkaloid, stemocurtisine (2), with a novel pyrido[1,2-a]azapine A,B-ring system, has been isolated from root extract of Stemona curtisii. The structure and relative stereochemistry was determined by spectral data interpretation X-ray crystallography.

A novel copper (II) ions [Cu(II)]-graphene oxide (GO) nanocomplex-modified screen-printed carbon electrode (SPCE) is successfully developed as a versatile electrochemical platform for construction of sensors without an additionally external redox probe. simple strategy to prepare the GO-modified SPCE described. Such GO based on adsorbed Cu(II) prepared by incubation in solution. This work demonstrates fabrications two kinds sensors, i.e., new label-free immunosensor and non-enzymatic sensor...

Elsholtzia is a genus in the family Lamiaceae, and some species this are commonly used for food ethnomedicinal formulations by ethnic groups of China Thailand. Despite their apparent utility, few studies have been conducted to evaluate potential as sources medicinally active agents. We aimed investigate cytotoxicity ethanolic extracts from three selected edible plant most promising extract was further characterized bioactive constituents signaling mechanisms associated with anti-leukemic...

The isolation of two new Stemona alkaloids, 1-hydroxyprotostemonine and stemocurtisine N-oxide, a benzofuran, stemofuran L, from the root extracts curtisii is reported. major known alkaloids this plant extract, stemocurtisine, stemocurtisinol, oxyprotostemonine, were also isolated along with oxystemokerrine N-oxide. nonalkaloid components extract included benzofuran derivative, stemofurans F, J, K, dihydro-γ-tocopherol, stigmasterol. Stemocurtisine stemocurtisinol converted to their...

The ethanolic rhizome extracts of Kaempferia species (K. angustiflora, K. elegans, galanga-1, galanga-2, galanga-3, marginata, parviflora, pulchra, and rotunda) were evaluated for their UV protective antioxidant properties. effective parviflora further isolated 18 pure compounds obtained. Flavokawain B (1), a chalcone found in exhibited the most UVA UVB protection, more potent than commercial sunscreens. Compound 1 demonstrated highest activities ABTS, DPPH, FRAP assays.Abbreviations: ABTS:...

Two new dihydrostemofoline alkaloids, 11(S),12(R)-dihydrostemofoline (3) and stemoburkilline (4), along with stemofoline (1) 2'-hydroxystemofoline (2) have been isolated from a root extract of Stemona burkillii Prain. The structure relative configuration 3 determined via spectroscopic data comparison synthetic 11(S),12(S)-dihydrostemofoline (5). the exo-cyclic alkene group in 4 is tentively assigned as E on basis mechanistic considerations.

Semisynthesis studies starting from (11Z)-1′,2′-didehydrostemofoline (4) indicated that the known Stemona alkaloid stemoburkilline is Z-isomer and not E-isomer as initially reported. The semisynthesis involved conversion of to 11(S),12(S)-dihydrostemofoline (3) followed by a stereoselective base-catalyzed ring-opening reaction give (Z)-stemoburkilline (8). same product was obtained using similar synthetic protocol isostemofoline (6) via based-catalyzed 11(S),12(R)-dihydrostemofoline (1). A...

A green chemistry experiment is presented for teaching an undergraduate quantitative analysis/analytical laboratory class through the use of black tea leaf extract determination iron in supplement tablets. Dried a safe, low cost, and widely available source natural that can be used place more toxic chemicals (for example, 1,10-phenanthroline) or other uncommon reagents may hard to obtain outside their native lands. Various student learning outcomes accommodated within this include principles...

The performance of organic solar cells was improved by the effect a synergistic gold quantum dot/plasmonic grating system.

Essential oils from the aerial parts of four Elsholtzia species; stachyodes, communis, griffithii and beddomei were obtained by steam distillation their chemical components analysed gas chromatography-mass spectrometry (GC-MS). Principle Component Analysis was used to identify variations in essential these plants, which could be categorised into two groups according main are acylfuran derivatives oxygenated monoterpenes. Additionally, anti-acne inducing bacterial activity against...

Four types of traditional Thai rice—polished, black fragrant, glutinous and rice—were separately used as raw material for vinegar production. During alcohol fermentation, using enriched baker’s dried yeast (S. cerevisiae) a starter culture gave the highest ethanol content over 7 days fermentation. The conversion to acetic acid production by Acetobacter pasteurianus TISTR 102 was performed 25 days. amount detected with rice fermentation (6.68% w/v). biological properties vinegars were...

The essential oil constituents of the Kaempferia species, specifically K. angustiflora, marginata and three varieties galanga, i.e., galanga 1, 2 3 from Chiang Mai Province, Thailand, were studied using gas chromatography-mass spectrometry (GC-MS). Monoterpene hydrocarbons cinnamate derivatives identified as phytochemical markers these species. chemical variation oils was investigated Principle Component Analysis (PCA). Cinnamate found to be main components in whereas angustiflora consisted...

The present study aimed to investigate the antibacterial activity of ethanolic Kaempferia parviflora extracts and combined effects plant's specific compounds with gentamicin against clinical strains carbapenem-resistant Klebsiella pneumoniae, Pseudomonas aeruginosa, Acinetobacter baumannii. minimal inhibitory concentrations (MIC) tested bacterial were determined by using broth microdilution. extract investigated a checkerboard assay expressed as fractional concentration index (FICI). Crude...

A new Stemona alkaloid glycoside derivative, 6-hydroxy-5,6-seco-stemocurtisinoside (4), was isolated from the ethanolic extract of aerial parts curtisii Hook.f., together with stemocurtisine (1), (11Z)-1',2'-didehydrostemofoline (2) and 6-hydroxy-5,6-seco-stemocurtisine (3). Whereas, stemocurtisinol (5) oxyprotostemonine (6) were roots. Their structures elucidated using 1D 2D NMR spectroscopy as well MS experiments. The pure compounds evaluated for their cytotoxicities larvicidal activities...