Abstract Background Probiotics provide benefits for reducing acne. Previous studies showed an anti‐inflammatory effect of Lactobacillus paracasei . However, the clinical evidence topical probiotic lotion and acne treatment is still lacking. Objective To evaluate efficacy safety probiotic‐derived compared with 2.5% benzoyl peroxide in mild‐to‐moderate vulgaris. Methods Topical was formulated from cell‐free supernatant L MSMC 39‐1. In vitro study ability to inhibit both antibiotic‐resistance...

The efficacy of the Lacticaseibacillus paracasei MSMC 36-9 strain with probiotic potential to ferment coconut milk and produce yogurt-type beverages was examined. Tapioca starch used as a stabilizer at concentrations 0, 1.0, 2.0% (w/w). samples were stored 4 °C for 21 days analyzed viability resistance in vitro gastrointestinal conditions L. 36-9, pH changes, radical scavenging activity using 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay, apparent viscosity. remained stable during storage...

Modern treatment, a healthy diet, and physical activity routines lower the risk factors for metabolic syndrome; however, this condition is associated with all-cause cardiovascular mortality worldwide. This investigation involved randomized controlled trial, double-blind, parallel study. Fifty-eight participants of syndrome according to inclusion criteria were into two groups given probiotics ( Lacticaseibacillus paracasei MSMC39-1 Bifidobacterium animalis TA-1) (n = 31) or placebo 27). The...

Introduction: Seborrheic dermatitis (SD) is one of the most common relapsing–remitting scalp diseases. The symptoms SD are relieved by many treatments, including antifungal shampoos such as zinc pyrithione, selenium sulfide, and azole shampoos. This study aimed to investigate effects a shampoo containing green‐synthesized silver nanoparticles (AgNPs) in relieving SD. Methods: Bergamot peel moringa leaf extracts were produce AgNP. Characteristic AgNP particle was. AgNPs assessed determine...

Aging is a physiological process that impacts multiple systems of organs. Alzheimer's disease (AD) the most common form dementia in elderly, and it major problem aging societies. The development AD linked to an accumulation amyloid beta Tau proteins, which impair cognition cause memory loss. We studied whether probiotics strains could protect how effectively might delay age-related changes. Two probiotics, Lactobacillus paracasei MSMC39-1 Bifidobacterium animalis MSMC83 strain, were...

Chronic coronary syndrome (CCS) has a high mortality rate, and dyslipidemia is major risk factor. Atherosclerosis, cause of CCS, influenced by gut microbiota dysbiosis its metabolites. The objective this study was to the diversity composition related clinical parameters among CCS patients undergoing angiography in comparison healthy volunteers Thailand. had more factors higher inflammatory markers, high-sensitivity C-reactive protein (hs-CRP) than others. alpha lower group. A significant...

Human-derived lactobacilli were isolated from fecal samples of healthy volunteers. Forty-six isolates different volunteers selected and investigated for their immunomodulatory properties. Conditioned medium each isolate was assessed its effect on tumor necrosis factor (TNF) production in lipopolysaccharide-activated THP-1 monocytes. Of 46 Lactobacillus isolates, 12 significantly inhibited TNF varying magnitude. strain TH58 displayed the most potent TNF-inhibitory activity (70% inhibition)....

Corydalis plants containing isoquinoline alkaloids are reported to possess promising phamacological properties for the treatment of important diseases including cancer, inflammation, Alzheimer's disease and microbial infections. As part a wider program investigating Bhutanese medicinal plants,.we have previously identified eight from C. dubia. Out these, we report here on two major alkaloids, scoulerine (1) cheilanthifoline (2) their inhibitory activities against acetylcholinesterase...

Probiotics have been shown to possess several properties, depending on the strain. Some probiotics important roles in preventing infection and balancing immune system due interaction between intestinal mucosa cells system. This study aimed examine properties of three probiotic strains using tumor necrosis factor-alpha (TNF-α) inhibition test colorectal adenocarcinoma (Caco-2 cells). It was revealed that viable heat-killed L. paracasei strain MSMC39-1 dramatically suppressed TNF-α secretion...

Hypercholesterolemia is a significant risk factor for cardiovascular disease and metabolic disorders. Probiotics are the essential constituents of gastrointestinal microbiota that provide health-promoting effects. Cholesterol-lowering activity specific property probiotics, improving cholesterol metabolism without adverse Thus, purpose this study was to investigate hypocholesterolemic effect single mixed cholesterol-lowering probiotic strains (including Limosilactobacillus reuteri TF-7,...

The chemical constituents and biological activities of Corydalis crispa (Fumariaceae) were investigated for the first time. phytochemical study resulted in isolation nine known isoquinoline alkaloids: protopine (1), 13-oxoprotopine (2), 13-oxocryptopine (3), stylopine (4), coreximine (5), rheagenine (6), ochrobirine (7), sibiricine (8) bicuculline (9), with complete NMR data 2 3 provided here Crude extracts exhibitedsignificant anti-inflammatory (p < 0.01) activity against TNF-alpha...

Benzoyl peroxide (BPO) is an effective acne treatment and has been used as a cleanser short contact therapy. However, data on the minimum time of BPO needed to kill Cutibacterium acnes are lacking. Thus, aim this study was determine commonly concentrations for bactericidal effects C. acnes.An in vitro experimental clinically isolated performed minimal inhibitory concentration (MIC) using broth microdilution method. Subsequently, times various were evaluated, their assessed by plate count...

We have hydrodistilled the essential oil (EO) from aerial parts of Bhutanese medicinal plant, Pleurospermum amabile using a Clevenger apparatus and evaluated this EO by GC/GC-MS NMR analysis followed testing for bioactivity. The GC-MS identified 52 compounds with (E)-isomyristicin as major component (32.2%). Repeated purification yielded four compounds; (1), (E)-isoapiol (2), methyl eugenol (3) (E)-isoelemicin (4). Compound 2 mother showed best antiplasmodial activity against Plasmodium...

With the objective of determining safety and verifying traditional uses Bhutanese medicinal plant, Pleurospermum amabile Craib &amp; W. Smith, we investigated its crude extracts isolated phytochemicals for their biological activities. Four phenylpropanoids [( E)-isomyristicin (1), ( E)-isoapiol (2), methyl eugenol (3) E)-isoelemicin (4)] six furanocoumarins [psoralen (5), bergapten (6), isoimperatorin (7), isopimpinellin (8), oxypeucedanin hydrate (9) methanolate (10)] were from this plant....

The development of many chronic diseases is associated with an excess free radicals leading to harmful oxidative stress. Certain probiotic strains have been shown antioxidant and anti-aging properties are important resource for microbial antioxidants. present study aimed explore the protection offered by Bifidobacterium animalis strain MSMC83 in a model stress induced D-galactose (D-gal). Male Sprague Dawley rats were randomly allocated four groups: control group injected saline,...

Background: Balanced diversity and abundance of gut microbiome play important roles in human health, including neonatal health. Though not established, there is evidence that the delivery route could alter microbiomes. Objective: The objective study was to investigate differences microbiomes neonates delivered via cesarean section compared those born by vaginal identify predominant microbial taxa present each group. Study Design: A prospective observational 281 healthy between February 2021...