A5087970775- Natural Antidiabetic Agents Studies
- Natural Compound Pharmacology Studies
- Phytochemicals and Antioxidant Activities
- Diet, Metabolism, and Disease
- Pharmacological Effects of Natural Compounds
- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Food Science and Nutritional Studies
- Carbohydrate Chemistry and Synthesis
- Drug-Induced Hepatotoxicity and Protection
- Diverse Scientific Research Studies
- Microencapsulation and Drying Processes
- Essential Oils and Antimicrobial Activity
- Phytochemicals and Medicinal Plants
- Flavonoids in Medical Research
- Pharmacogenetics and Drug Metabolism
- Polysaccharides and Plant Cell Walls
- Antibiotics Pharmacokinetics and Efficacy
- Biological Activity of Diterpenoids and Biflavonoids
- Synthesis of Organic Compounds
National Cancer Institute of Thailand
2023-2024
Mahidol University
2022-2023
Srinakharinwirot University
2012-2013
This study investigated the in vivo and vitro activity of α-mangostin (α-MG), most abundant xanthone mangosteen pericarp, on HT-29 cell tumorigenicity, proliferation, several markers tumor activity, as well profile amounts xanthones serum, tumor, liver, feces.Balb/c nu/nu mice were fed either control diet or containing 900 mg α-MG/kg. After 1 week acclimation to diet, injected subcutaneously with cells same diets ad libitum for an additional 2 4 weeks. weeks, mass concentrations BcL-2...
Lysiphyllum strychnifolium (Craib) A. Schmitz (LS) (Fabaceae) has traditionally been used to treat diabetes mellitus.This study demonstrates the antidiabetic and antioxidant effects of aqueous extract LS leaves in vivo vitro.The leaf on glucose uptake, sodium-dependent cotransporter 1 (SGLT1) transporter 2 (GLUT2) mRNA expression Caco-2 cells, α-glucosidase, lipid peroxidation were evaluated vitro. The using an oral tolerance test (OGTT) a 28-day consecutive administration streptozotocin...
Context: Triphala is a traditional herbal formulation consisting of dried fruits from three plants namely, Terminalia bellirica, chebula and Phyllanthus emblica. Its used to treat many ailments, including various types cancers, health promotion, longevity. Aims: To evaluate the ability an aqueous extract (TPL) inhibit growth Hepatocellular carcinoma cells (HepG2) in mice. Methods: The anticancer activity TPL its composite extracts was assessed vitro by MTT assay with HepG2 cells. mice were...
Salak seed extract (Salacca zalacca) is known for its high antioxidant content and low caffeine levels, making it a promising candidate the development of value-added health products. However, there lack scientific evidence anti-hyperglycemic effects. To address this, we investigated in vitro vivo effects salak extract. The HPLC chromatogram shows prominent peak that corresponds to chlorogenic acid. In studies revealed seeds inhibited α-glucosidase activity glucose uptake Caco-2 cells...
Lysiphyllum strychnifolium (Craib) A. Schmitz (LS, Fabaceae) is one of the folklore medicines in Thailand. The previous studies have demonstrated several pharmacological activities and high polyphenolic substances possessed by this plant. However, suitable encapsulation LS extract has not been discovered. This study aimed to develop microcapsules using spray-drying technique with pectin as a carrier. Moreover, powder analysis characterization were also conducted. effects inlet temperatures...
This study aims to develop a self-nanoemulsifying drug delivery system (SNEDDS) solve the limited oral bioavailability problem of apigenin, bioactive flavonoid. Apigenin-loaded SNEDDS consisting Gelucire 44/14, Tween 80, and PEG 400 in mass ratios 25:37.5:37.5 30:35:35 were prepared, designated as GTP2575 GTP3070, respectively. The physicochemical stability at 30 40 ºC for 6 months was evaluated good found. vitro transport apigenin across Caco-2 monolayers from vivo pharmacokinetics rats...
Direct evidence of Triphala-drug interactions has not been provided to date.This study was aimed determine the effects Triphala on cytochrome P450 (CYP) isoforms and P-glycoprotein (P-gp) in vitro, investigate pharmacokinetic with CYP-probes rats.Effects activities CYP P-gp were examined using human liver microsomes (HLMs) Caco-2 cells, respectively. Pharmacokinetic between (i.e., phenacetin midazolam) further rats.Triphala extract inhibited order CYP1A2>3A4>2C9>2D6 IC50 values 23.6 ± 9.2,...