Clitoria ternatea L., a natural food-colorant containing anthocyanin, demonstrated antioxidant and antihyperglycemic activity. The aim of this study was to determine the effects flower extract (CTE) on postprandial plasma glycemia response status in healthy men. In randomized, crossover study, 15 men (ages 22.53 ± 0.30 years; with body mass index 21.57 0.54 kg/m2) consumed five beverages: (1) 50 g sucrose 400 mL water; (2) 1 CTE (3) 2 (4) (5) water. Incremental glucose, insulin, uric acid,...

This study aimed to investigate the effects of gac fruit juice and its probiotic fermentation (FGJ) utilizing Lactobacillus paracasei on modulation gut microbiota production short-chain fatty acids (SCFAs). We conducted a comparison between FGJ, non-fermented (GJ), control samples through in vitro digestion colonic using human derived from fecal inoculum. Our findings revealed that both GJ FGJ led an increase viability Lactobacilli, with exhibiting even higher levels compared control. The...

With the global increase in hyperglycemia and hyperlipidemia, there is an urgent need to explore dietary interventions targeting inhibition of dipeptidyl peptidase-IV (DPP-IV) lipid digestion absorption. This study investigated how Lactobacillus rhamnosus GG (LGG) affects various aspects black goji berry (BGB) (Lycium ruthenicum Murr.) juice, including changes physicochemical functional properties, as well microbiological sensory attributes. Throughout fermentation process with 2.5–10% (w/v)...

Mesona chinensis Benth (Chinese Mesona), an economically significant agricultural plant, is the most widely consumed as herbal beverage in Southeast Asia and China. The objective of this study was to evaluate inhibitory activity (MC) extract on formation advanced glycation end products (AGEs) protein oxidation vitro model fructose-mediated glycation. content total polyphenolic compounds measured by using Folin–Ciocalteu assay. Antiglycation determined AGE fluorescence intensity,...

The aim of this study was to investigate the stability and antioxidant activity polyphenols from Mesona chinensis Benth extract (MCE) its alginate-based encapsulation by extrusion technique during simulated gastrointestinal digestion. efficacy ranged 41.1 ± 4.7 56.7 3.4% with different concentrations MCE (50–75% v/v), sodium alginate (1.2–1.8% w/v), CaCl2 solution (3–5% w/v). optimal condition for MCE-loaded beads (MCB) composed 75% MCE, 1.5% alginate, 3% solution, which provided highest...

Abstract Postprandial hyperglycemia and hyperlipidemia are key contributors to chronic metabolic disturbances, thereby promoting the onset progression of cardiovascular diseases diabetes. Current dietary interventions aim effectively control postprandial glucose lipid levels while ensuring adequate antioxidant intake. Black rice ( Oryza sativa L.) cultivations have gained attention for their resistant starch content phytochemical compositions. Notably, black is rich in anthocyanins, known...

Metabolic dysfunction and hepatic abnormalities, such as those associated with high-fat, high-fructose (HFHFr) diets, are major contributors to obesity-related health issues. The growing interest in sustainable dietary interventions has highlighted the potential of plant-based byproducts. Dragon fruit (Hylocereus undatus) peel waste, rich bioactive compounds fibers, phenolics, betacyanins, represents a promising functional ingredient for managing these disorders. This study investigated...

Cyanidin-3-rutinoside (C3R), a naturally occurring anthocyanin, possesses anti-oxidant, anti-hyperglycemic, anti-glycation and cardioprotective properties. However, its mechanisms responsible for anti-hyperlipidemic activity have not been fully identified. The aim of the study was to investigate lipid-lowering C3R through inhibition lipid digestion absorption in vitro. inhibitory against pancreatic lipase cholesterol esterase evaluated using enzymatic fluorometric colorimetric assays,...

Obesity and overweight are consistently associated with metabolic disorders including hyperglycemia hyperlipidemia. Herbal medicines have been currently suggested as an alternative source of potentially useful antihyperglycemic, antihyperlipidemic, antioxidant activities. The objective this study was to assess the in vitro inhibitory effects eleven herbal on carbohydrate lipid digestive enzymes key steps digestion inhibition micelle formation ability bind bile acid. In addition, activity...

Isoferulic acid (IFA), a naturally occurring cinnamic derivative, is main active ingredient of the rhizoma Cimicifuga dahurica. It has been shown various pharmacological activities. The aim study was to investigate effect IFA against MG-induced protein glycation and oxidative DNA damage. Free radical scavenging activity MGO-trapping abilities were also investigated. fluorescent MG-derived AGEs non-fluorescent Nε-(carboxymethyl) lysine (Nε-CML) measured using spectrofluorometer an enzyme...

Advanced glycation end-products (AGEs) play a significant role in the development and progression of vascular complication diabetes. Anthocyanin has been recently reported to possess antiglycating activity. This study aimed determine whether naturally occurring anthocyanin, cyanidin-3-rutinoside (C3R) inhibits methylglyoxal (MG) induced protein oxidative DNA damage. C3R (0.125–1 mM) was incubated with bovine serum albumin MG (1 for 2 weeks. The formation fluorescent AGEs measured by using...

Riceberry rice (Oryza sativa L.) is a new pigmented variety of from Thailand. Despite its high anthocyanin content, effect on adipogenesis and adipocyte function remains unexplored. We investigated whether extract (RBE) impacted cell proliferation by examining viability cycle, using preadipocyte 3T3-L1 cells. To test RBE’s formation, cells were cultured in adipogenic medium supplemented with number triglyceride levels quantified. Furthermore, Akt1 phosphorylation along RT-qPCR intracellular...

Excessive consumption of cookies has been linked to harmful health outcomes owing the presence refined carbohydrates and heat-induced toxicants including end products lipid peroxidation dietary advanced glycation (dAGEs). To address this issue, study explores addition dragon fruit peel powder (DFP), which is rich in phytochemicals fibers, as a potential solution mitigate their adverse effects. The results indicate that adding DFP at 1%, 2%, 5% w/w raw cookie dough significantly improves...

Edible plants constitute a potential source for controlling postprandial hyperglycemia and oxidative stress. The objective of this study was to investigate in vitro antioxidant intestinal α-glucosidase inhibitory activities Mesona chinensis (MC). In addition, the acute effect MC on glucose plasma status after consumption high carbohydrate (HC) meal by overweight subjects also determined. results showed that total phenolic flavonoid contents extract were 212.37 ± 5.64 mg gallic acid...

Riceberry rice (Oryza sativa L.), a new cross-breed from Hom Nin rice, local non-glutinous purple and Khoa Dawk Mali 105. The present study systematically assessed the effect of extract (RBE) on inhibition key steps carbohydrate lipid digestion absorption. main anthocyanin identified in RBE was cyanidin-3-O-glucoside peonidin-3-O-glucoside. In step absorption, markedly inhibited intestinal maltase sucrase. Kinetic analysis demonstrated that mix-type competitive inhibitor against maltase....

Several studies have documented the hypolipidemic effect of anthocyanin-rich plants in vitro and vivo. The objective this study was to elucidate inhibitory activity fraction from Thai berries against fat digestive enzymes. ability bind bile acid, disrupt cholesterol micellization uptake into Caco-2 cells also determined. content total phenolics, flavonoid anthocyanin Prunus domestica L. (TPE), Antidesma bunius (L.) Spreng, Syzygium cumini Skeels, nervosum A. Cunn. Ex DC 222.7–283.5 mg gallic...

Lysiphyllum strychnifolium (Craib) A. Schmitz (LS) (Fabaceae) has traditionally been used to treat diabetes mellitus.This study demonstrates the antidiabetic and antioxidant effects of aqueous extract LS leaves in vivo vitro.The leaf on glucose uptake, sodium-dependent cotransporter 1 (SGLT1) transporter 2 (GLUT2) mRNA expression Caco-2 cells, α-glucosidase, lipid peroxidation were evaluated vitro. The using an oral tolerance test (OGTT) a 28-day consecutive administration streptozotocin...

Dietary plant-based foods contain combinations of various bioactive compounds such as phytochemical and vitamins. The combined effect these vitamins phytochemicals remains unknown, especially in the prevention diabetes its complications. present study aimed to investigate ascorbic acid gallic on fructose-induced protein glycation oxidation. Ascorbic (15 μg/mL) (0.1 reduced formation advanced end products (AGEs) bovine serum albumin (BSA; 10 mg/mL) by 15.06% 37.83%, respectively. combination...

Recently, the mechanisms responsible for anti-glycation activity of cyanidin and its derivatives on inhibition methylglyoxal (MG)-induced protein glycation advanced glycation-end products (AGEs) as well oxidative DNA damage were reported. In this study, we investigated protective effect against MG-induced stress apoptosis in rat INS-1 pancreatic β-cells. Exposure cells to cytotoxic levels MG (500 µM) 12 h caused a significant reduction cell viability. However, pretreatment with alone...

The pigment of riceberry rice has been reported to contain anthocyanins which act as a free radical scavenger and inhibitor carbohydrate digestive enzymes. Since the probiotic yogurt incorporated with extract was previously developed, present study aimed investigate acute effect consumption on postprandial glycemic response, antioxidant capacity, subjective ratings in healthy adults. In cross-over design, 19 participants were randomized consume 350 g supplemented 0.25% (w/w) or control...

High-fat (HF) meal-induced postprandial lipemia, oxidative stress and low-grade inflammation is exacerbated in overweight obese individuals. This dysmetabolism contributes to an increased risk of cardiovascular disease metabolic disorders. Clitoria ternatea flower extract (CTE) possesses antioxidant potential carbohydrate fat digestive enzyme inhibitory activity vitro. However, no evidence supporting a favorable role CTE the modulation status humans presently exists. In present study, we...

As a by-product of dragon fruit consumption, peel (DFP) was developed into powder as natural ingredient. Nevertheless, the effect DFP on physicochemical properties flours used in Asian food processing and cooking remains unknown. In this study, starch digestibility, thermal, pasting, (potato, rice, glutinous wheat) were characterized. It found that contained 65.2% dietary fiber together with phenolic compounds, betacyanins, antioxidant activity. The results demonstrated (from 125 to 500 mg)...