A5019755982- Pharmacy and Medical Practices
- Pharmacological Effects of Natural Compounds
- Herpesvirus Infections and Treatments
- Safe Handling of Antineoplastic Drugs
- Antibiotics Pharmacokinetics and Efficacy
- Natural Antidiabetic Agents Studies
- Ion channel regulation and function
- Pharmaceutical Practices and Patient Outcomes
- Pharmaceutical studies and practices
- Toxin Mechanisms and Immunotoxins
- Vestibular and auditory disorders
- Cardiac electrophysiology and arrhythmias
- Drug Transport and Resistance Mechanisms
- Gout, Hyperuricemia, Uric Acid
- Glaucoma and retinal disorders
- Clinical practice guidelines implementation
- Cancer therapeutics and mechanisms
- Food Allergy and Anaphylaxis Research
- Virus-based gene therapy research
- Pharmacogenetics and Drug Metabolism
- Phytochemistry and Biological Activities
- Phytochemicals and Antioxidant Activities
- Retinal Development and Disorders
- Tea Polyphenols and Effects
- Poxvirus research and outbreaks
Showa University
2013-2024
Showa Pharmaceutical University
2003-2024
Pharmac
2008-2020
Hokkaido University
2016
Ajinomoto (Japan)
2015-2016
Tokyo Medical University
2002-2012
Kanazawa Medical University
2011
University of Toyama
2011
keiyu Hospital
2008
Ajinomoto (United States)
2004
Abstract
The specific binding of 3H-labeled gamma-aminobutyric acid ([3H]GABA) to synaptic plasma membranes from rat brains was inhibited by various quinolonecarboxylic derivatives (quinolones), and these inhibitions were concentration dependent. [3H]muscimol GABAA sites also inhibited. These inhibitory potencies differed widely among the quinolones examined. Dixon plots showed that a newly developed difluorinated quinolone, NY-198 [1-ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-...
18F-fluorodeoxyglucose positron emission tomography combined with computed (FDGPET/CT) is widely used as a standard method for evaluating human brown adipose tissue (BAT), recognized therapeutic target of obesity. However, longitudinal BAT study using FDG-PET/CT lacking owing to limitations the method. Near-infrared time-resolved spectroscopy (NIR(TRS)) technique density noninvasively. This aimed test whether NIRTRS could detect changes in during or after long-term intervention. First,...
Our previous study reported that a dried bonito broth known in Japan as 'dashi' improved or ameliorated mood states, including fatigue, during the daily lives of human subjects. Histidine is an amino acid present broth, and we sought to evaluate whether histidine would affect feelings fatigue humans. We investigated effects intake on feeling states mental task performance by performing placebo-controlled, double-blind crossover trial. Twenty subjects with high sleep disruption scores were...
Silver is a transition metal that known to be less toxic than platinum. However, only few studies have reported the anticancer effects of some silver complexes and their possibility as an alternative platinum complex. This study investigated thiosulfate complex (STS), [Ag(S2O3)2]3-, consisting sodium thiosulfate.In vitro cytotoxic activity STS was comparatively in human cancer cell lines (K562 MCF-7) normal cells (mesenchymal stem mammary epithelial cells). For its effects, cycle, mode...
Lysiphyllum strychnifolium (Craib) A. Schmitz (LS) (Fabaceae) has traditionally been used to treat diabetes mellitus.This study demonstrates the antidiabetic and antioxidant effects of aqueous extract LS leaves in vivo vitro.The leaf on glucose uptake, sodium-dependent cotransporter 1 (SGLT1) transporter 2 (GLUT2) mRNA expression Caco-2 cells, α-glucosidase, lipid peroxidation were evaluated vitro. The using an oral tolerance test (OGTT) a 28-day consecutive administration streptozotocin...
Chatuphalatika (CTPT), is a Thai herbal formulation mixture of Phyllanthus emblica Linn. (Euphorbiaceae), Terminalia belerica (Combretaceae), T. chebula and the fruit arjuna (Roxb.) Wight & Arn. CTPT considered to exert anti-inflammatory antihyperuricemic effects, but there have been no reports demonstrate these pharmacological effects in quantitative manner.To investigate antioxidative, CTPT.Antioxidant activities extracts were measured vitro by DPPH, ABTS FRAP assays, effect measuring...
ABSTRACT Varicella-zoster virus (VZV) open reading frame 21 (ORF21) is one of at least five VZV genes expressed in latently infected human and rodent ganglia. To determine whether ORF21 required for latent lytic infection, we deleted 99% from the viral genome. The deletion mutant could be propagated only a cell line expressing protein. Insertion herpes simplex type 1 (HSV-1) homolog ORF21, HSV-1 UL37, into failed to complement growth culture. Inoculation cotton rats with resulted infection...
Varicella-zoster virus (VZV) results in a latent infection humans after primary infection. Latency has also been established guinea pigs and rats inoculation with the virus. It was found that of cotton Oka vaccine strain VZV To begin to identify which genes are required for latency, we infected is deleted ORF61. ORF61 protein transactivates certain promoters enhances infectivity viral DNA transient transfections. Deletion abnormal syncytia impairs growth vitro. Inoculation ORF61-deleted...
Varicella-zoster virus (VZV) results in a lifelong latent infection human sensory and cranial nerve ganglia after primary infection. VZV open reading frame 47 (ORF47) ORF66 encode protein kinases that phosphorylate several viral proteins, including glycoprotein gE ORF32, ORF62, ORF63 proteins. Here we show the ORF47 kinase also phosphorylates gI. While is essential for replication T cells skin, found gene to be dispensable establishment of dorsal root rodents. expressed during latency....
Pharmacognosy Magazine ,2019,15,60,98-106.DOI:10.4103/pm.pm_14_18Published:January 2019Type:Original Article Authors:Vilasinee Hirunpanich Sato, Savita Chewchinda, Narawat Nuamnaichati, Supachoke Mangmool, Bunleu Sungthong, Pilanthana Lertsatitthanakorn, Shinako Ohta, and Hitoshi Sato Author(s) affiliations:Vilasinee Sato1, Chewchinda2, Nuamnaichati1, Mangmool1, Sungthong3, Lertsatitthanakorn4, Ohta5, Sato6 1Department of Pharmacology, Faculty Pharmacy, Mahidol University, Bangkok, Thailand...
Hepatocellular carcinoma (HCC) recurrence rate consists of 10%-20% and remains the leading cause cancer-related death. We have successfully designed protocol for adoptive immunotherapy to liver cirrhotic patients with HCC. In our study we shown that activated lymphocytes, containing much immune cells innate immunity, from healthy volunteers, a vigorous anticancer effect. However, volume viability treatment lymphocytes might lead limited effects. aimed develop new therapeutic approach...
The simple suspension method is a of administering drugs via feeding or gastrostomy tube, and it involves allowing tablets capsules to be disintegrated suspended in warm water at 55℃ without crushing. present study evaluated the stability two prodrugs alone combination with an alkaline agent according method. used ester-prodrugs, acemetacin (AMT) cefpodoxime proxetil (CPP), which are hydrolyzed higher pH. Drug concentrations were measured by high-performance liquid chromatography. AMT CPP...