A5049074926- Adipose Tissue and Metabolism
- Thermoregulation and physiological responses
- Cardiovascular Disease and Adiposity
- Exercise and Physiological Responses
- Diabetes Management and Research
- Sports Performance and Training
- Diabetes Treatment and Management
- Muscle metabolism and nutrition
- Fibroblast Growth Factor Research
- Diet and metabolism studies
- Protease and Inhibitor Mechanisms
- Nutrition, Health and Food Behavior
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Pancreatic function and diabetes
- Cerebrovascular and Carotid Artery Diseases
- Advanced Glycation End Products research
- Cardiovascular and exercise physiology
- Liver Disease Diagnosis and Treatment
- Genetics and Physical Performance
- Behavioral Health and Interventions
- MicroRNA in disease regulation
- Consumer Attitudes and Food Labeling
- Nutrition and Health in Aging
- Cardiovascular Effects of Exercise
- Lipoproteins and Cardiovascular Health
Kyoto Medical Center
2016-2024
The Ohio State University Wexner Medical Center
2020-2024
The Ohio State University
2024
Ritsumeikan University
2015-2016
Abstract Our aim was to determine the quantitative effects of a single-dose Nattokinase (NK) administration on coagulation/fibrinolysis parameters comprehensively in healthy male subjects. A double-blind, placebo-controlled cross-over NK intervention study carried out 12 young males. Following baseline blood draw, each subject randomized receive either 2,000 FU (NSK-SD, Japan Bio Science Laboratory Co., Ltd) or placebo with subsequent groups. Subjects donated samples at 2, 4, 6 and 8 hours...
18F-fluorodeoxyglucose positron emission tomography combined with computed (FDGPET/CT) is widely used as a standard method for evaluating human brown adipose tissue (BAT), recognized therapeutic target of obesity. However, longitudinal BAT study using FDG-PET/CT lacking owing to limitations the method. Near-infrared time-resolved spectroscopy (NIR(TRS)) technique density noninvasively. This aimed test whether NIRTRS could detect changes in during or after long-term intervention. First,...
Brown adipose tissue (BAT) contributes to the regulation of non-shivering thermogenesis and adiposity. Increasing BAT has recently attracted much attention as a countermeasure obesity. Animal studies have shown that prolonged catechin treatment increases uncoupling protein 1, thermogenic in BAT. On other hand, supportable evidence human is lacking. Thus, purpose this study was examine whether after ingestion humans. Twenty-two healthy young women were given either catechin-rich (540 mg/day;...
Objective Human brown adipose tissue (BAT) activity has been typically evaluated by 18F-fluorodeoxyglucose (FDG)-positron emission tomography (PET) combined with computed (CT). However, FDG-PET/CT serious limitations (e.g., radiation and cold exposure). This study BAT density using near-infrared time-resolved spectroscopy (NIRTRS), a simple noninvasive method of measuring the indices hemoglobin concentration [total-Hb] mitochondrial (µs′). Methods The NIRTRS parameters at 760, 800, 830 nm in...
Maslinic acid, derived from olive fruit, reduces pro-inflammation cytokines, which are involved in muscle fiber atrophy. Therefore, the maslinic acid ingestion may enhance muscular response to resistance training through anti-inflammatory action. We therefore conducted a parallel, double-blind, randomized, placebo-controlled trial that examined whether combination of supplementation and improve mobility functions community-dwelling elderly persons. Over 12-week period, 36 participants...
Brown adipose tissue (BAT) is responsible for non-shivering thermogenesis and an attractive therapeutic target combating obesity related diseases. Human BAT activity has been evaluated by 18F-fluorodeoxyglucose-positron emission tomography/computed tomography (18FDG-PET/CT) under acute cold exposure, but the method some serious limitations, including radiation exposure. Infrared thermography (IRT) may be a simple less-invasive alternative to evaluate activity. In present study, establish...
Abstract Background/objectives Disturbed circadian rhythm is associated with an increased risk of obesity and metabolic disorders. Brown adipose tissue (BAT) a site nonshivering thermogenesis (NST) plays role in regulating whole-body energy expenditure (EE), substrate metabolism, body fatness. In this study, we examined diurnal variations NST healthy humans by focusing on their relation to BAT activity. Methods Forty-four men underwent 18 F-fluoro-2-deoxy-D-glucose positron emission...
Exercise mediates tissue metabolic function through direct and indirect adaptations to acylcarnitine (AC) metabolism, but the exact mechanisms are unclear. We found that circulating medium-chain acylcarnitines (C12-C16) lower in active/endurance trained human subjects compared sedentary controls, this is correlated with elevated cardiorespiratory fitness reduced adiposity. In mice, exercise serum AC increased liver AC, was accompanied by a marked increase expression of genes involved hepatic...
Abstract Goto, M, Chikako, Hirayama, T, Terada, S, Nirengi, Kurosawa, Y, Nagano, A, and Hamaoka, T. Partial range of motion exercise is effective for facilitating muscle hypertrophy function through sustained intramuscular hypoxia in young trained men. J Strength Cond Res 33(5): 1286–1294, 2019—The acute response to long-term effects partial (PRE) full (FRE) elbow extensors were compared The PRE was expected increase the hypoxic environment, which theorized enhance muscular hypertrophy....
F18-fluorodeoxyglucose (FDG)–positron emission tomography (PET) along with computed (CT) is a standard method for assessing brown adipose tissue (BAT) activity. We tested the usefulness of near-infrared time-resolved spectroscopy (NIRTRS) as simple and noninvasive evaluating BAT density (BAT-d) by examining effects some factors known to influence The total hemoglobin concentration parameter BAT-d was evaluated using NIRTRS in supraclavicular region 413 Japanese individuals. associations were...
Background: Information about factors related to better adherence continuous glucose monitoring (CGM) sensor is quite limited. Materials and Methods: Forty-six participants with type 1 diabetes using subcutaneous insulin infusion (CSII) without CGM were recruited. The participants’ characteristics diabetes-related quality of life (QOL) evaluated at baseline one year after starting use CGM. Participants wearing the for ≥60% time considered as adherent. Results: mean age 46 was 44.1 ± 15.0...
Abstract Background Atrial fibrillation (AF) is the most common sustained arrhythmia, with growing evidence identifying obesity as an important risk factor for development of AF. Although defective atrial myocyte excitability due to stress-induced remodeling ion channels commonly observed in setting AF, little known about mechanistic link between and Recent studies have identified increased cardiac late sodium current ( I Na,L ) downstream calmodulin-dependent kinase II (CaMKII) activation...
ABSTRACT Purpose The physiological response induced by acute prolonged sitting is not fully understood. Therefore, we examined the effects of 8-h constant on microcirculation and associated factors in lower extremity among healthy males. We also evaluated protective lower-pressure thigh-length elastic compression garments these parameters. Methods Nine males (age, 22.6 ± 1.4 yr; body mass index, 22.4 1.8 kg·m −2 ) completed experiment. Following baseline measurements, each subject was...
Abstract Aims/Introduction The distributer of the anti‐glutamic acid decarboxylase antibody assay kit using radioimmunoassay ( RIA ) recently announced its discontinuation, and proposed an alternative enzyme‐linked immunosorbent ELISA ). aim present study was to investigate diagnostic values by among type 1 diabetes mellitus patients control participants. Materials Methods A total 79 age‐matched controls were enrolled assessed . Sensitivity, specificity, positive predictive negative...
Polycystic ovary syndrome (PCOS) is a common endocrine disorder among reproductive-aged women. While PCOS associated with an increased risk of obesity and insulin resistance, little known regarding the prevalence factors for nonalcoholic fatty liver disease (NAFLD) Japanese women PCOS. We estimated elevated enzymes, as index NAFLD, in PCOS.We retrospectively reviewed 102 who visited Department Gynecology, Kyoto Medical Center Japan from January 2000 to September 2016. Inclusion criterion was...
Given the major role of glucose-dependent insulinotropic polypeptide (GIP) in regulation adiposity, this study examined effects induced by a diet based on Japanese tradition (SMART WASHOKU) visceral fat area (VFA) and GIP secretions.Overweight/obese men (n = 21; mean age, 41.0 ± 9.0 years; BMI, 25.2 2.0 kg/m2) without diabetes were placed either SMART WASHOKU or control meal for 2 weeks, randomized, cross-over setup with four-week washout period.For tolerance test, blood samples collected at...
Human brown adipose tissue (BAT) activity is associated with lower body fatness and favorable glucose metabolism. Previous studies reported that oral fructose loading induces postprandial fibroblast growth factor 21 (FGF21) secretion. FGF21 a known inducer of thermogenesis; however, the effects diet-induced secretion on BAT thermogenesis remain to be elucidated. The both single load daily consumption were examined using randomized cross-over trial 2-week controlled (RCT), respectively. In...
Background: High-density lipoprotein (HDL) containing apolipoprotein A-I is associated with the pathogenesis of Alzheimer’s disease (AD). HDL particle size modified in presence pathological conditions, while significance remains controversial. Objective: The aim this study was to investigate subclasses mild cognitive impairment (MCI) and AD. Methods: This cross-sectional included 20 AD patients, 17 MCI age-matched controls without impairment, selected from database Study Outcome...
Brown adipose tissue (BAT) is sympathetically activated and induces thermogenesis during cold exposure, thereby influencing energy expenditure body fat levels. The very low frequency (VLF) components of pulse rate variability could be a form thermogenic sympathetic nervous activity, but no clear relationship has yet been reported between VLF activity BAT density. We therefore aimed to evaluate the association them.We enrolled 20 adults in winter matched summer. assessed densities based on...
BACKGROUND/OBJECTIVES: Advanced glycation end products (AGEs) contribute to the pathophysiology of lifestyle-related diseases.To identify nutrients associated with AGEs, this study explored factors by investigating relationship between changes and blood AGEs during a weight loss program in obese women.SUBJECTS/METHODS: Twenty-five women (age: 50 ± 8 years, body mass index: 28.7 3.4 kg/m 2 ) underwent energy-restricted meal replacement for months.Three-day weighted dietary records tests...