A5056962945- Diet and metabolism studies
- Adipose Tissue and Metabolism
- Bariatric Surgery and Outcomes
- Body Contouring and Surgery
- Mitochondrial Function and Pathology
- Cardiovascular Disease and Adiposity
- Muscle metabolism and nutrition
- Cardiac Fibrosis and Remodeling
- Muscle Physiology and Disorders
- Body Image and Dysmorphia Studies
- Sports Performance and Training
- Acute Myocardial Infarction Research
- Thermoregulation and physiological responses
- Gallbladder and Bile Duct Disorders
- Cardiac Imaging and Diagnostics
- Sports injuries and prevention
- Obsessive-Compulsive Spectrum Disorders
- Mesenchymal stem cell research
- Sport Psychology and Performance
- Obesity and Health Practices
- Appendicitis Diagnosis and Management
- Gastrointestinal disorders and treatments
- Minimally Invasive Surgical Techniques
- Metabolomics and Mass Spectrometry Studies
- Hernia repair and management
The Ohio State University
2020-2024
The Ohio State University Wexner Medical Center
2020-2024
Lung Institute
2024
Universitat de Barcelona
2024
HM Hospitales
2018
Hospital del Mar Research Institute
2012-2014
Universitat Autònoma de Barcelona
2012-2013
Municipal Institute for Medical Research
2012
Laboratoire de Biologie du Développement
2005
Centre National de la Recherche Scientifique
2005
Background: Brown adipose tissue (BAT) is an important for thermogenesis, making it a potential target to decrease the risks of obesity, type 2 diabetes, and cardiovascular disease, recent studies have also identified BAT as endocrine organ. Although has been implicated be protective in this point there are no that identify direct role mediate cardiac function. Methods: To determine on function, we utilized model transplantation. We then performed lipidomics increase lipokine...
Obsessive-compulsive disorder (OCD) is a severe psychiatric condition. The authors present their experience with Gamma Knife radiosurgery (GKRS) in the treatment of patients OCD resistant to any medical therapy.
Exercise mediates tissue metabolic function through direct and indirect adaptations to acylcarnitine (AC) metabolism, but the exact mechanisms are unclear. We found that circulating medium-chain acylcarnitines (C12-C16) lower in active/endurance trained human subjects compared sedentary controls, this is correlated with elevated cardiorespiratory fitness reduced adiposity. In mice, exercise serum AC increased liver AC, was accompanied by a marked increase expression of genes involved hepatic...
Obesity and its co-morbidities including type 2 diabetes are increasing at epidemic rates in the U.S. worldwide. Brown adipose tissue (BAT) is a potential therapeutic to combat obesity diabetes. Increasing BAT mass by transplantation improves metabolic health rodents, but clinical translation remains challenge. Here, we investigated if of 2-4 million differentiated brown pre-adipocytes from mouse stromal fraction (SVF) or human pluripotent stem cells (hPSCs) could improve health....
Brown adipose tissue (BAT) is correlated to cardiovascular health in rodents and humans, but the physiological role of BAT initial cardiac remodeling at onset stress unknown. Activation via 48 h cold (16°C) mice following transverse aortic constriction (TAC) reduced gene expression for LCFA uptake oxidation male accelerated metabolic remodeling, with an early isoform shift carnitine palmitoyltransferase 1 (CPT1) toward increased CPT1a, entry long chain fatty acid (LCFA) into oxidative...
We assessed aging hallmarks in skin, muscle, and adipose the genetically diverse HET3 mouse, generated a broad dataset comparing these to individual animal diagnostic SNPs from 4 founding inbred strains of line. For middle- old-aged mice, we provided running wheel exercise ensure our observations were not purely representative sedentary animals, but age-related phenotypes improved with activity. Adipose tissue fibrosis, peripheral neuropathy, loss neuromuscular junction integrity consistent...
Aerobic exercise is an important component of rehabilitation after cardiovascular injuries including myocardial infarction (MI). In human studies, the beneficial effects MI are blunted in patients who obese or glucose intolerant. Here, we investigated on MI-induced cardiac dysfunction and remodeling mice chronically fed a high-fat diet (HFD).C57Bl/6 male were either standard (Chow; 21% kcal/fat) HFD (60% for 36 weeks. After 24 weeks diet, randomly subjected to (MI) sham surgery (Sham)....
The prevalence of metabolic diseases is rapidly increasing and a principal contributor to this diet, including increased consumption energy-rich foods with added phosphates. Exercise an effective therapeutic approach combat disease. While exercise the detrimental effects high-fat diet on health, high-phosphate have not been thoroughly investigated. Here, we investigated or in presence absence voluntary function male mice. To do this, mice were fed low-fat, normal-phosphate (LFPD), (HPD)...
Autologous adipose tissue is commonly used for engraftment the purposes of soft reconstruction due to its relative abundance in human body and ease acquisition using liposuction methods. This has led adoption autologous procedures that allow injection tissues be as a "filler" correcting cosmetic defects deformities tissues. However, clinical use such methods several limitations, including high resorption rates poor cell survivability, which lead low graft volume retention inconsistent...