A5065233408- Cannabis and Cannabinoid Research
- Alzheimer's disease research and treatments
- Seaweed-derived Bioactive Compounds
- Gastrointestinal motility and disorders
- Neuroscience and Neuropharmacology Research
- GABA and Rice Research
- Gastroesophageal reflux and treatments
- Cholinesterase and Neurodegenerative Diseases
- Neuropeptides and Animal Physiology
- Ginkgo biloba and Cashew Applications
- Biochemical Analysis and Sensing Techniques
- Protein Hydrolysis and Bioactive Peptides
- Ion Channels and Receptors
- Helicobacter pylori-related gastroenterology studies
- Parkinson's Disease Mechanisms and Treatments
- Neuroscience of respiration and sleep
- Biochemical effects in animals
- Tea Polyphenols and Effects
- Phytochemicals and Antioxidant Activities
- Oral health in cancer treatment
- Urinary Bladder and Prostate Research
- Sleep and Wakefulness Research
- Morinda citrifolia extract uses
- Eosinophilic Esophagitis
- Cancer, Stress, Anesthesia, and Immune Response
The University of Adelaide
2016-2025
Faculty of Public Health
2016-2020
Bond University
2006
Royal Adelaide Hospital
2000-2002
Hanson Institute
2000-2001
With the global increase in hyperglycemia and hyperlipidemia, there is an urgent need to explore dietary interventions targeting inhibition of dipeptidyl peptidase-IV (DPP-IV) lipid digestion absorption. This study investigated how Lactobacillus rhamnosus GG (LGG) affects various aspects black goji berry (BGB) (Lycium ruthenicum Murr.) juice, including changes physicochemical functional properties, as well microbiological sensory attributes. Throughout fermentation process with 2.5–10% (w/v)...
Introduction Many chemotherapy agents used to treat advanced cancer are inherently mucotoxic, causing breakdown of the gastrointestinal mucosa (gastrointestinal mucositis (GI-M)) and lead a constellation secondary complications including diarrhoea, malnutrition, anorexia, pain, fatigue sleep disturbances. These symptoms usually managed individually, leading polypharmacy its associated risks. The endocannabinoid system regulates numerous biological behavioural processes with side effects,...
Plant polyphenols such as the lignin honokiol pictured are able to bind specific regions in amyloid β oligomer and this may be associated with neuroprotective effects neuronal cells.
The effects of cannabinoid subtype 1 (CB ) receptor activation were determined on smooth muscle, inhibitory and excitatory motorneuronal function in strips human colonic longitudinal muscle (LM) circular (CM) vitro . Electrical field stimulation (EFS; 0.5–20 Hz, 50 V) evoked a relaxation LM CM precontracted with neurokinin‐2 (NK‐2) selective agonist ( β ‐ala 8 ‐neurokinin A; 10 −6 M the presence atropine (10 ); this was unaltered following pretreatment CB ‐receptor...
GABA B -receptor (GABA R) agonists reduce transient lower esophageal sphincter relaxation (TLESR) and reflux episodes through an action on vagal pathways. In this study, we determined whether R are expressed afferent neurones they modulate distension-evoked discharge of afferents in the isolated stomach. Vagal mehanoreceptor activity was recorded following distensions ferret proximal stomach before after perfusion with R-selective baclofen 3-aminopropylphosphinic acid (3-APPiA). Retrograde...
White tea (WT) is one of six types originally derived from Fujian Province, China. known for its health-promoting properties. However, the neuroprotective and anti-aggregatory properties WT against hallmark toxic Alzheimer’s protein, Aβ have not been investigated. In this study, WT, green (GT), oolong (OT) black (BT) were manufactured using leaves cultivar Camellia sinensis (Jin Guanyin). The protective effects these extracts then studied under oxidative stress conditions via t-bhp H2O2...
Aggregation of α-Synuclein (αS) protein to amyloid fibrils is a neuropathological hallmark Parkinson's disease (PD). Growing evidence suggests that extracellular αS aggregation plays pivotal role in neurodegeneration found PD addition the intracellular aggregates Lewy bodies (LB). Here, we identified and compared diverse set molecules capable mitigating exogenous toxicity αSA53T, more aggregation-prone mutant familial PD. For first time, investigated anti-amyloid activity semi-synthetic...
The impact of extract composition on the neuroprotective activities Ecklonia radiata was investigated in multiple assays vitro. A total six fractions (crude (CE), phlorotannin (PT), polysaccharide (PS), free sugar (FS), low molecular weight (LM), and high (HM)) prepared from E. were used to determine their effects against Aβ1-42 oxidative stress neuronal cell line PC-12. Only three (CE, PS, HM) demonstrated cytotoxicity at least highest concentration (100 μg/mL) tested PC-12 cells. All...
Abstract Background Phytocannabinoids (pCBs) have been shown to inhibit the aggregation and neurotoxicity of neurotoxic Alzheimer's disease protein beta amyloid (Aβ). We characterized capacity six pCBs—cannabichromene (CBC), cannabigerol (CBG), cannabinol (CBN), cannabidivarin (CBDV), cannabidiol (CBD) Δ 9 ‐tetrahydrocannabinol (Δ ‐THC)—to disrupt Aβ protect against Aβ‐evoked in PC12 cells. Methods Neuroprotection lipid peroxidation Aβ‐induced cytotoxicity was assessed using MTT assay....