Nanocrystals, a carrier-free colloidal delivery system in nano-sized range, is an interesting approach for poorly soluble drugs. Nanocrystals provide special features including enhancement of saturation solubility, dissolution velocity and adhesiveness to surface/cell membranes. Several strategies are applied nanocrystals production precipitation, milling, high pressure homogenization combination methods such as NanoEdge™, SmartCrystal Precipitation-lyophilization-homogenization (PLH)...

The aim of this study was to encapsulate cannabidiol (CBD) extract in nanostructured lipid carriers (NLCs) improve the chemical stability and anti-inflammatory activity CBD for dermal delivery. CBD-loaded NLCs (CBD-NLCs) were prepared using cetyl palmitate (CP) as a solid stabilized with Tego® Care 450 (TG450) or poloxamer 188 (P188) by high-pressure homogenization (HPH). loaded at 1% w/w. Three different oils employed produce CBD-NLCs, including Transcutol® P, medium-chain triglycerides...

Nanotechnology is strongly accepted as the crucial approach in drug delivery that can influence therapeutic performance of hydrophobic drugs.Self-nanoemulsifying systems (SNEDDS) are one proven methods increase solubility and bioavailability poorly water soluble drugs.SNEDDS anhydrous homogenous liquid mixtures consisting oil, surfactant, co-surfactant, drugs, which spontaneously form o/w nanoemulsions when diluted with under gentle agitation.SNEDDS provide several potential effects on oral...

Abstract Self-nanoemulsifying drug delivery systems (SNEDDS) have been used to improve the oral bioavailability of various drugs. In current study, apigenin was developed as SNEDDS solve its dissolution problem and enhance antioxidant potential. were prepared by mixing Gelucire 44/14, Tween 80, PEG 400 under controlled conditions. The droplet diluted demonstrated a spherical shape with size less than 100 nm neutral charge. very fast self-emulsification obtained within 32 s, transmittance...

Pumpkin seed oil (PSO)-loaded niosomes were prepared from Tween 20 and cholesterol by ethanol injection. Confocal microscopy showed better skin permeation hair follicle accumulation of the compared to PSO solution. The PSO-loaded inhibited 5α-reductase activity in DU-145 cells hindered IL-6 RAW 264.7 cells. These effects indicated great potential reduce loss. scalp serum with did not show irritation reconstructed human skin. This formulation presented a significant decrease percentage fallen...

Pumpkin seed oil (PSO) provides many health benefits including antioxidant, cardiovascular boost, treatment of benign prostatic hyperplasia (BPH), and reduction hair loss. The main objective this study was to design a suitable formulation niosomes encapsulated PSO for topical delivery. Formulation PSO-loaded optimised by altering the types surfactant amount PSO:surfactant:cholesterol. developed were spherical shape with size range 138-366 nm. formulated Tween 20 provided smallest particle...

Nanostructured lipid carriers (NLC) were prepared from solid (glyceryl monostearate, GMS) and vegetable oils, including palm oil (PO), rice bran (RBO) or virgin coconut (VCO), at different ratios (95:5, 90:10 80:20), while nanoemulsions (NE) with sole oils. After production, the particle size of lutein-free NLC NE was found to be between 100 150 nm increased after loading lutein. An increase in reduced resulted a less ordered matrix an % entrapment efficiency. From stability study, it...

Abstract Background Collagen peptides from various sources demonstrate benefits in health and well‐being both vitro clinical trials. However, there is a scarce study of collagen Tuna on skin health. Aims To investigate the impact derived ( Katsuwonus pelamis Thunnus albacares ) health, utilizing biological studies randomized controlled trial. Methods In human dermal primary fibroblasts were evaluated terms elastin synthesis senescent cell inhibition. A randomized, placebo‐controlled,...

Phyllanthus emblica Linn. (PE) has been used to promote hair growth for decades. In this study, dried PE fruit powder was extracted, tested biological activities, and loaded into transfersomes follicle targeting. Before lyophilization, extracted using 2 solvent systems, water 30% ethanol. The ethanolic extract had higher antioxidant activity total phenolic content than the aqueous extract. However, cytotoxicity of that As a result, analyzed ultra-performance liquid chromatography found major...

This study aimed to evaluate the effect of solid lipid and oil structures on physicochemical properties, kinetic release, photostability, photoprotection nanostructured carriers (NLC) containing octyl methoxycinnamate (OMC). OMC was used as a model compound since it is an effective sunscreen agent widely in products; however, unstable after ultraviolet radiation (UVR) exposure. OMC-loaded NLC were prepared from different lipids (cetyl palmitate (CP) or tristearin) oils (caprylic/capric...

Clindamycin is the antibiotic of choice for treating Cutibacterium acnes (C. acnes) which was presented in various dosage forms such as topical solution, gel, and foam. In this current study, clindamycin formulated peel-off mask intending to form film, providing drug release profile a sustained manner leading better antimicrobial efficacy enabling after use. The gel designed into many formulations with varying concentrations film-forming agents. major agent 10 %w/w PVA that combined...

This study aims to develop a self-nanoemulsifying drug delivery system (SNEDDS) solve the limited oral bioavailability problem of apigenin, bioactive flavonoid. Apigenin-loaded SNEDDS consisting Gelucire 44/14, Tween 80, and PEG 400 in mass ratios 25:37.5:37.5 30:35:35 were prepared, designated as GTP2575 GTP3070, respectively. The physicochemical stability at 30 40 ºC for 6 months was evaluated good found. vitro transport apigenin across Caco-2 monolayers from vivo pharmacokinetics rats...