A5065338803- Mosquito-borne diseases and control
- CAR-T cell therapy research
- Immunotherapy and Immune Responses
- Bioactive Compounds and Antitumor Agents
- Immune Cell Function and Interaction
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Medicinal Plant Studies
- Malaria Research and Control
- Viral Infections and Vectors
- Phytochemical compounds biological activities
- Piperaceae Chemical and Biological Studies
- Seaweed-derived Bioactive Compounds
- Antimicrobial Peptides and Activities
- Natural Compound Pharmacology Studies
- Cancer Immunotherapy and Biomarkers
- Phytochemistry and Bioactivity Studies
- Fungal Biology and Applications
- Insect symbiosis and bacterial influences
- Insect and Pesticide Research
- Phytochemistry and Bioactive Compounds
- Echinoderm biology and ecology
- Healthcare and Venom Research
- Microbial Inactivation Methods
- Algal biology and biofuel production
- Cancer Mechanisms and Therapy
Chiang Mai University
2018-2025
Mahidol University
2010-2022
Siriraj Hospital
2010-2022
Harvard University
2019
Joslin Diabetes Center
2019
Tumor escapes host immune responses by producing immunosuppressive cytokines, such as IL-10 and TGF-β, secreted into the tumor microenvironment. These cytokines play important roles in suppression of dendritic cell (DC) function, leading to decreased effector CD4+ CD8+ T cells. To improve DC functions enhance cytolytic activity activated T-cells, we suppressed effect these on DCs using specific neutralizing antibodies that inhibit TGF-β receptors. Monocyte-derived generated vitro showed...
Gentamicin (GM) is an aminoglycoside antibiotic which commonly used against Gram-negative bacterial infection; however, serious complications including nephrotoxicity could limit its clinical use.The present study examined the protective effects of curcumin (CUR) on endoplasmic reticulum (ER) stress-mediated apoptosis through antioxidative property in GM-induced rats.Male Sprague-Dawley rats (n = 3) were divided into six groups to receive normal saline (control), GM (100 mg/kg/day),...
Cancer is the leading cause of death worldwide. Drug resistance and relapse after current standard treatments frequently occur; thus, alternative effective are required. Algae cyanobacteria abundant organisms that serve as bioresources nutrients/metabolites, which attractive sources numerous bioactive compounds for drug discovery. In present study, we, therefore, investigated anti-cancer activities crude polysaccharide ethanolic extracts from Chlorella sp., Sargassum spp., Spirulina sp....
Herpes simplex virus (HSV) is known to cause cold sores and various diseases in humans. Importantly, HSV infection can develop latent recurrent infections, it also inflammation. These infections are difficult control, effective treatment of the disease remains a challenge. Thus, search for new antiviral anti-inflammatory agents necessity. Melittin major peptide that present venom honeybee. It possesses number pharmacological properties. In this study, effects melittin peptides from A....
Cholangiocarcinoma (CCA) presents a significant clinical challenge which is often identified in advanced stages, therby restricting the effectiveness of surgical interventions for most patients. The high incidence cancer recurrence and resistance to chemotherapy further contribute bleak prognosis low survival rates. To address this pressing need effective therapeutic strategies, our study focuses on development an innovative cellular immunotherapy, specifically utilizing chimeric antigen...
Dengue virus (DENV) infection causes mild to severe illness in humans that can lead fatality cases. Currently, no specific drug is available for the treatment of DENV infection. Thus, development an anti-DENV urgently required. Cordycepin (3′-deoxyadenosine), which a major bioactive compound Cordyceps (ascomycete) fungus has been used centuries Chinese traditional medicine, was reported exhibit antiviral activity. However, activity cordycepin unknown. We hypothesized exerts and that, as...
Abstract Cholangiocarcinoma (CCA) is a lethal cancer with rapid progression and poor survival. Novel more effective therapies than those currently available are, therefore, urgently needed. Our research group previously reported the combination of gemcitabine cytotoxic T lymphocytes to be single-agent treatment for elimination CCA cells. However, cells upregulates expression an immune checkpoint protein (programmed death-ligand 1 [PD-L1]) that consequently inhibits cytotoxicity lymphocytes....
Mesua ferrea L. is used in Ayurvedic and Thai medicine for treating various diseases, including diabetes. This study aimed to isolate identify the bioactive constituents from M. leaves with potential α‐glucosidase inhibitory activity using a bioassay‐guided fractionation approach. From ethyl acetate fraction most potent effect, we isolated eight polyphenols, six coumarins (1−6) two flavonoids (7−8). Notably, five compounds (1, 2, 4, 6, 8) displayed significant IC50 value ranging 1.81 42.97...
The Bacillus cereus group frequently contaminates milk and dairy products. Some members of this can produce the heat-stable pre-formed toxin cereulide, which causes emetic foodborne intoxication. This study characterised B. isolates from raw cow’s in biochemical, genetic, toxigenic aspects. Of 158 derived 99 samples, 7 (4.43%) harboured cereulide synthetase A (cesA), encodes a associated with phenotype. Heat-treated culture filtrates cesA-positive demonstrated cytotoxicity to HepG2 Caco-2...
Lung cancer remains one of the most lethal malignancies, often diagnosed at advanced stages, leading to limited treatment options. Thus, identifying natural products with potent anti-cancer activity is crucial for improving outcomes. While melittin from Apis mellifera (Mel-AM) has been extensively studied, florea (Mel-AF), a bee species native Southeast Asia, relatively underexplored. These peptides were comparatively investigated against non-small cell lung (NSCLC) lines, A549, NCI-H460,...
Dengue virus (DENV) infection has become a public health problem worldwide. The development of anti-DENV drug is urgently needed because neither licensed vaccine nor specific currently available. Inhibition DENV attachment and entry to host cells by blocking envelope (E) protein an attractive strategy for development. A hydrophobic pocket on the E essential structural transition in membrane fusion, inhibition this process able inhibit infection. To search safe drug, we identified short...
Abstract The therapeutic activities of food‐derived bioactive proteins and peptides are attracting increased attention within the research community. Medicinal plants used in traditional medicines an excellent source peptides, especially those traditionally prepared by water extraction for use as tea or food supplement. In this study, novel were isolated from enzymatic digests 33 Thai medicinal plants. inhibitory activity each against dengue virus ( DENV ) infection was investigated. Of...
Dengue virus (DENV) infection is a public health problem worldwide; thus, the development of vaccine and anti-DENV drugs urgently needed. It has been observed that low levels viremia in DENV-infected individuals are associated with mild disease outcomes; therefore, reduction DENV load should offer therapeutic benefits. Disruption protein-protein interactions on surface by peptide mimics part its structural protein may affect stability virion structure inhibit viral entry into host cells. To...
Second-generation anti-CD19-chimeric antigen receptor T cells (anti-CD19-CAR2 cells) are effective for treating B-cell malignancies; however, anti-CD19-CAR2 can induce human anti-mouse immune responses because anti-CD19 single-chain variable fragment (scFv) in the CAR molecules is derived from a murine FMC63 (mFMC63) monoclonal antibody. Consequently, persistence of mFMC63-CAR2 and their therapeutic efficiency patients decreased, which results tumor relapse. In an attempt to remedy this...
Breast cancer (BC) is the most common in women. Although standard treatments are successful patients with BC diagnosed at an early stage, alternative treatment required for advanced‑stage disease who do not respond to these treatments. The concept of using chemotherapy sensitize cells become susceptible immunotherapy was recently introduced and may be used as BC. chemotherapeutic drug doxorubicin has been reported cells; however, efficacy solid spheroids, addition its underlying mechanism...
Triple-negative breast cancer (TNBC) is a highly aggressive subtype currently lacking effective treatment options. Consequently, novel and drugs or compounds are urgently needed to treat TNBC. Therefore, this study aimed evaluate the potential of 7R-acetylmelodorinol (7R-AMDL), phytochemical compound isolated from Xylopia pierrei Hance, plant found in Thailand, as therapeutic agent for MTT clonogenic assays showed that 7R-AMDL significantly reduced survival cell lines, with markedly potent...
Immunotherapy harnessing immune functions is a promising strategy for cancer treatment. Tumor sensitization one approach to enhance tumor cell susceptibility cytotoxicity that can be used in combination with immunotherapy achieve therapeutic efficiency. Cordycepin, bioactive compound extracted from some Cordyceps spp. has been reported effectively inhibit growth, however, the mechanism of its activity enhances unknown. In present study, we investigated potency cordycepin sensitize lethal...