A5084521790- Protein Hydrolysis and Bioactive Peptides
- Antimicrobial Peptides and Activities
- Mosquito-borne diseases and control
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Viral Infections and Vectors
- Peptidase Inhibition and Analysis
- Advanced Proteomics Techniques and Applications
- Insect Utilization and Effects
- Meat and Animal Product Quality
- Malaria Research and Control
- Invertebrate Immune Response Mechanisms
- GABA and Rice Research
- Aquaculture Nutrition and Growth
- Plant Stress Responses and Tolerance
- Biochemical and Structural Characterization
- MicroRNA in disease regulation
- Photosynthetic Processes and Mechanisms
- Probiotics and Fermented Foods
- Gut microbiota and health
- Metabolomics and Mass Spectrometry Studies
- Plant-Microbe Interactions and Immunity
- Aquaculture disease management and microbiota
- Antibiotic Resistance in Bacteria
- Phytase and its Applications
- Transgenic Plants and Applications
National Science and Technology Development Agency
2016-2025
National Center for Genetic Engineering and Biotechnology
2016-2025
Kasetsart University
2019-2024
Advanced Neural Dynamics (United States)
2023
National Centre for Genetic Resources and Biotechnology
2013-2023
Prince of Songkla University
2022
Centro de Ingeniería Genética y Biotecnología
2016-2022
Thammasat University
2022
Phramongkutklao Hospital
2022
Hebei Academy of Agriculture and Forestry Sciences
2020
Abstract Phytophthora palmivora, an oomycete pathogen, induces leaf fall disease in rubber trees (Hevea brasiliensis), causing significant economic losses. Effective management requires understanding metabolic dynamics during infection. This study employed untargeted metabolomic and proteomic analyses to investigate the response of seedling leaves P. palmivora Metabolomic profiling revealed 1702 979 metabolite peaks positive negative ionization modes, respectively, with 212 metabolites...
Abstract Chikungunya virus (CHIKV) has recently re‐emerged causing millions of infections in countries around the Indian Ocean. While CHIKV a broad host cell range and productively infects number different types, macrophages have been identified as potential viral reservoir serving to increase duration symptoms. To date no interacting protein characterized this study sought identify binding proteins expressed on target membranes. Two‐dimensional overlay prohibitin (PHB) microglial protein....
Abstract Chikungunya virus (CHIKV) is a re-emerging mosquito-borne alphavirus that has recently engendered large epidemics around the world. There no specific antiviral for treatment of patients infected with CHIKV and development compounds significant anti-CHIKV activity can be further developed to practical therapy urgently required. Andrographolide derived from Andrographis paniculata , herb traditionally used treat number conditions including infections. This study sought determine...
BACKGROUND: Fish collagen has been paid increasing attention as an alternative to the mammalian counterpart owing abundance of fish skin a processing by-product. Generally, low yield extracted using typical acid solubilisation process led use pepsin aid for yield. Alternatively, pepsin, especially from tuna stomach, can be used extraction pepsin-solubilised (PSC). Therefore objective this study was extract and characterise PSC bigeye snapper, widely surimi production in Thailand. RESULTS:...
The mosquito transmitted Dengue virus (DENV) remains a significant public health problem in many tropical and subtropical countries. Increasing evidence has suggested that during the infection process cellular lipids play important roles at several stages of replication cycle. This study sought to characterize changes lipid metabolism gene expression investigated role one enzyme, fatty acid synthase, DENV infection. Transcriptional profiles genes associated with were evaluated by real-time...
Monoclonal antibodies with specific antigens have been widely used as targeted therapy for cancer. Hep88 mAb is a monoclonal antibody which shows binding anti-cancer effects against the HepG2 cell line. However, its mechanisms of action are still not completely understood. We examined cycling and apoptosis by flow cytometry mRNA expression factors involved in paraptosis mAb-treated cells real-time PCR. The cell-cycle analysis demonstrated that growth-inhibitory activity was associated G2/M...
Andrographolide is a major bioactive constituent of Andrographis paniculata that has been shown in vitro to have antiviral activity against number viruses, including the mosquito transmitted dengue virus (DENV). However, how andrographolide exerts an anti-DENV effect remains unclear. This study therefore sought further understand mechanism action inhibiting DENV infection liver cells using proteomic based approach. Both 1 dimension (D) and 2D proteome systems were used. Initial data was...
Abstract Many mosquito transmitted viruses of the genera Alphavirus and Flavivirus are human pathogens significant concern, there is currently no specific antiviral for any member these two genera. This study sought to investigate broad utility orlistat (tetrahydrolipstatin) in reducing virus infection several borne including flaviviruses (dengue (DENV; nine isolates analyzed), Japanese encephalitis (JEV; one isolate analyzed) Zika (ZIKV; 2 analyzed)) as well an alphavirus (chikungunya...
Chitooligosaccharide (COS), found in both insects and marine sources, has several bioactivities, such as anti-inflammation antioxidant activities. However, the mechanism of shrimp shell COS on retardation inflammatory effects is limited. Therefore, aim this study to examine aforementioned activities LPS-activated RAW264.7 macrophage cells. significantly improved cell viability at level 500 µg/mL could reduce TNF-α, NO IL-6 generations cells (p < 0.05). Furthermore, ROS formation, NF-κB...
Abstract Background Due to their resistance and difficulty in treatment, biofilm-associated infections are problematic among hospitalized patients globally account for 60% of all bacterial humans. Antibiofilm peptides have recently emerged as an alternative treatment since they can be effectively designed exert a different mode biofilm inhibition eradication. Methods A novel antibiofilm peptide, BiF, was from the conserved sequence 18 α-helical by template-assisted technique its activity...
Human cardiac microvascular endothelial cells (HCMECs) are sensitive to ischemia and vulnerable damage during reperfusion. The release of damage-associated molecular patterns (DAMPs) reperfusion induces additional tissue damage. current study aimed identify early protein DAMPs in human subjected ischemia-reperfusion injury (IRI) using a proteomic approach their effect on cell injury. HCMECs were 60 min simulated 6 h reperfusion, which can cause lethal the culture media liquid...