A5045157677- Cancer Immunotherapy and Biomarkers
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Genomics and Chromatin Dynamics
- Peptidase Inhibition and Analysis
- IL-33, ST2, and ILC Pathways
- RNA and protein synthesis mechanisms
- CAR-T cell therapy research
- Cancer Cells and Metastasis
- RNA Research and Splicing
- Immune cells in cancer
- Genomics and Rare Diseases
- Histiocytic Disorders and Treatments
- Cancer, Hypoxia, and Metabolism
- Enzyme function and inhibition
- Syphilis Diagnosis and Treatment
- RNA modifications and cancer
- HIV/AIDS oral health manifestations
- Oral and gingival health research
- Immune Cell Function and Interaction
- Synthesis and Catalytic Reactions
Mahidol University
2020-2024
Siriraj Hospital
2020-2024
Prince of Songkla University
2012-2014
Abstract Background Carcinoma-associated fibroblasts (CAFs) play a critical role in cancer progression and immune cell modulation. In this study, it was aimed to evaluate the roles of CAFs-derived IL-6 doxorubicin (Dox) resistance PD-L1-mediated chimeric antigenic receptor (CAR)-T breast (BCA). Methods CAF conditioned-media (CM) were collected, level measured by ELISA. CAF-CM treated MDA-MB-231 HCC70 TNBC lines si (IL-6R) knocked down (KD) cells determine effect CAF-derived on Dox flow...
Interleukin 33 (IL-33) promotes cholangiocarcinoma (CCA) genesis in a mouse model, however, its function human CCA has not been clearly understood. This study was aimed to investigate IL-33 level tissues and clinicopathological correlations. The results revealed that found both cancer cells stromal cancer-associated fibroblast (CAFs) staining patterns which were divided into high (CH) low (CL) cells; presence (FP) absence (FA) CAFs. Kaplan-Meier analysis showed patients the CL group...
Aim: Neurexin 1 has two major protein isoforms using alternative promoters, coding for the alpha-neurexin (α-NRXN1) and beta-neurexin (β-NRXN1) genes. This study is to explore possibility that variants of NRXN1 gene predispose intellectual disability (ID) autism spectrum disorder (ASD). Methods: The regions in 24 exons exon–intron boundaries were investigated 115 Thai patients with ID ASD by direct DNA sequencing. Results: Nine novel identified. Four found β-NRXN1 gene, one variant six GGC...
Background The objectives of this study were to determine (i) the expression oral secretory leukocyte protease inhibitor ( SLPI ) in HIV ‐infected subjects compared with non‐ controls, (ii) antiretroviral therapy ART those without , and (iii) factors associated . Methods Oral tissues samples both un‐stimulated stimulated saliva collected from HIV‐infected ART, non‐HIV individuals. mRNA tissue was determined by quantitative real‐time PCR. Salivary protein detected using ELISA. Chi‐square test...
Background/Aim: The functions of interleukin 33 (IL-33) in cholangiocarcinoma (CCA) are unclear. This study aimed to evaluate the roles IL-33 CCA progression. Materials and Methods: effect intracellular using shIL-33 knocked down KKU-055 (IL-33KD-KKU-055) compared parental (Pa) extracellular recombinant human (rhIL-33) treatment on proliferation invasion cells grown 3D cultures was studied. Relevant markers were determined by western blot or ELISA. Results: IL-33KD-KKU-055 showed increased...
Background: Immune evasion in cancer is a multifaceted process that synchronizes pro-tumoral immune infiltration, immunosuppressive inflammation, and inhibitory checkpoint expression (IC). Recent developments have immunotherapies such as blockade (ICB) chimeric antigen receptor T-cell (CAR-T) therapy effectively impede this but benefit limited patient cohort. This investigation introduces systemic immunotherapeutic strategy by inhibition of master-regulators (MR-IE). Methods: We utilized the...
Background: Cancer immune evasion is a multifaceted process that synchronizes pro-tumoral infiltration, immunosuppressive inflammation, and inhibitory checkpoint expression (IC). Current immunotherapies combat this issue by reinstating immunosurveillance of tumors; however, it benefits limited patient population. Thus, more effective immunotherapeutic strategy warranted to cater specific populations. This investigation introduces novel via inhibition master regulators (MR-IE). Methods:...