A5027050921- Cholangiocarcinoma and Gallbladder Cancer Studies
- Bioactive Compounds and Antitumor Agents
- Synthesis and biological activity
- Drug Solubulity and Delivery Systems
- Cancer therapeutics and mechanisms
- Computational Drug Discovery Methods
- Cancer Mechanisms and Therapy
- Biochemical Analysis and Sensing Techniques
- Cytokine Signaling Pathways and Interactions
- Lung Cancer Treatments and Mutations
- Drug Transport and Resistance Mechanisms
- Glycosylation and Glycoproteins Research
- Protein Structure and Dynamics
- melanin and skin pigmentation
- Quinazolinone synthesis and applications
- HER2/EGFR in Cancer Research
- Pharmacological Effects of Natural Compounds
- SARS-CoV-2 and COVID-19 Research
- Phytochemicals and Antioxidant Activities
- Phytochemistry and biological activity of medicinal plants
- Synthesis and bioactivity of alkaloids
- Monoclonal and Polyclonal Antibodies Research
- Carbohydrate Chemistry and Synthesis
- Enzyme Structure and Function
- Chromatography in Natural Products
Khon Kaen University
2020-2025
Faculty (United Kingdom)
2021
Chulalongkorn University
2017-2020
Since the emergence of a novel coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome 2 (SARS-CoV-2) was first reported from Wuhan, China, neither specific vaccine nor an antiviral drug against SARS-CoV-2 has become available. However, combination two HIV-1 protease inhibitors, lopinavir and ritonavir, been found to be effective SARS-CoV, both drugs could bind well SARS-CoV 3C-like (SARS-CoV 3CLpro). In this work, molecular complexation between each inhibitor 3CLpro...
Janus kinases (JAKs) are enzymes involved in signaling pathways that affect hematopoiesis and immune cell functions. JAK1, JAK2, JAK3 play different roles numerous diseases of the system have also been considered as potential targets for cancer therapy. In present study, susceptibility oral JAK inhibitor tofacitinib against these three JAKs was elucidated using 500-ns molecular dynamics (MD) simulations free energy calculations based on MM-PB(GB)SA, QM/MM-GBSA (PM3 SCC-DFTB), SIE methods....
Epidermal growth factor receptor (EGFR) has been recognized as one of the attractive targets for anticancer drug development. Herein, a set anilino-1,4-naphthoquinone derivatives (3–18) was synthesized and investigated their EGFR inhibitory potentials. Among all tested compounds, three (3, 8, 10) were selected studying activity (in vitro in silico) due to most potent cytotoxic activities against six cancer cell lines (i.e., HuCCA-1, HepG2, A549, MOLT-3, MDA-MB-231, T47D; IC50 values =...
Mansonone G (MG), a plant-derived compound isolated from the heartwood of Mansonia gagei, possesses potent antitumor effect on several kinds malignancy. However, its poor solubility limits use for practical applications. Beta-cyclodextrin (βCD), cyclic oligosaccharide composed seven (1→4)-linked α-D-glucopyranose units, is capable encapsulating variety poorly soluble compounds into hydrophobic interior. In this work, we aimed to enhance water and anticancer activity MG by complexation with...
Human sweet taste receptor (hSTR) recognizes a wide array of sweeteners, resulting in perception. Maltitol and lactitol have been extensively used place sucrose due to their capability prevent dental caries. Herein, several molecular modeling approaches were applied investigate the structural energetic properties these two polyols/hSTR complexes. Triplicate 500 ns dynamics (MD) simulations mechanics/generalized Born surface area (MM/GBSA)-based free energy calculations revealed that TAS1R2...
The Janus kinase (JAK) and epidermal growth factor receptor (EGFR) have been considered as potential targets for cancer therapy due to their role in regulating proliferation survival of cells. In the present study, aromatic alkyl-amino analogs thiazole-based chalcone were selected experimentally theoretically investigate inhibitory activity against JAK2 EGFR proteins well anti-cancer effects on human cell lines expressing (TF1 HEL) (A549 A431). vitro cytotoxicity screening results...
Artocarpus lakoocha agglutinin (ALA), which specifically targets the Gal/GalNAc components of complex glycans, was isolated from seeds lakoocha. This study is first to explore role ALA in identifying aberrant designated ALA-binding glycans (ALAG), and its implications cholangiocarcinoma (CCA). ALA-histochemistry used evaluate ALAG expression liver fluke-induced CCA tissues hamsters (n = 60). Elevated observed hyperplastic ducts significantly increased tissues, while normal biliary epithelium...
Cholangiocarcinoma (CCA) or bile-duct cancer is most prevalent in Southeast Asian counties including Thailand. Patients present at an advanced stage when the often drug resistant, leading to chemotherapy failure. Curcumin has therapeutic potential with various anticancer properties. However, its effectiveness limited by low bioavailability, poor solubility, and instability. This study aimed synthesize, characterize evaluate efficacy of curcumin-loaded maltodextrin-based proniosomes (CMPNs)...
O‐GlcNAcylation is an important biological process in regulating the function of many nucleocytoplasmic proteins cells. Enhancement was associated with cancer development and progression. Here, we demonstrated involvement melanoma metastasis. Using data from GEO database, found that its related enzymes, including glutamine fructose‐6‐phosphate amidotransferase (GFAT), O‐GlcNAc transferase (OGT), O‐GlcNAcase (OGA); were elevated metastatic compared primary tumors normal tissues. Functional...
Alteration of glycosylation in cancer cells leads to the expression tumor-associated glycans, which can be used as biomarkers for diagnosis and prognostic prediction diseases. In this study, we nano-LC-QToF identify serum N-glycan detection brain tumors. We observed an increase sialylated N-glycans a decrease fucosylated patients with glioblastoma (GBM) meningioma (MG) compared healthy individuals. GBM, combination increased (6_4_0_2 compound) decreased (4_4_1_0 was identified most...
A new series of 1,4‐naphthoquinone‐triazole derivatives 5‐21 were synthesized using nucleophilic substitution and CuAAC reactions. The compounds investigated for their cytotoxic activities against four cancer cell lines (i.e., HuCCA‐1, T47D, MOLT‐3, HepG2) as well a normal line (Vero). Most the showed active effects all tested cells without cytotoxicity to cell. Particularly, compound 20 promising activity T47D with comparable effect that known drug, doxorubicin. Compounds 16 21 exhibited...
In the original publication [...]
The human T1R2-T1R3 sweet taste receptor (STR) plays an important role in recognizing various low-molecular-weight sweet-tasting sugars and proteins, resulting the release of intracellular heterotrimeric G protein that turn leads to perception. Xylitol sorbitol, which are naturally occurring sugar alcohols (polyols) found many fruits vegetables, exhibit potential caries-reducing effect widely used for diabetic patients as low-calorie sweeteners. In present study, computational tools were...
The recent ongoing coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome 2 (SARS-CoV-2) continues to rapidly spread across the world. To date, neither a specific antiviral drug nor clinically effective vaccine is available. Among 15 viral non-structural proteins (nsps), nsp16 methyltransferase has been considered as potential target due its crucial role in RNA cap 2′-O-methylation process, preventing virus detection cell innate immunity mechanisms. In...
Epidermal growth factor receptor (EGFR), overexpressed in many types of cancer, has been proved as a high potential target for targeted cancer therapy due to its role regulating proliferation and survival cells. In the present study, series designed vinyl sulfone derivatives was screened against EGFR tyrosine kinase (EGFR-TK) using silico vitro studies. The molecular docking results suggested that, among 78 sulfones, there were eight compounds that could interact well with EGFR-TK at...
Targeting L858R/T790M and L858R/T790M/C797S mutant EGFR is a critical challenge in developing tyrosine kinase inhibitors to overcome drug resistance non-small cell lung cancer (NSCLC). The discovery of next-generation (TKIs) therefore necessary. To this end, series furopyridine derivatives were evaluated for their EGFR-based inhibition antiproliferative activities using computational biological approaches. We found that several compounds derived from virtual screening based on molecular...
Neuraminidase (NA), a major glycoprotein found on the surface of influenza virus, is an important target for prophylaxis and treatment virus infections. Recently, several plant-derived polyphenols, especially caffeic acid analogs, have been reported to exert inhibitory activity against NA.Herein, we aimed investigate anti-influenza NA its hydroxycinnamate analogues, rosmarinic salvianolic A, in comparison known inhibitor, oseltamivir.In vitro MUNANA-based assay was used evaluate three...
Epidermal growth factor receptor (EGFR) is the key molecular target for non-small cell lung cancer (NSCLC) due to its major contribution complex signaling cascades modulating survival of cells. Targeting EGFR-mediated pathways has been proved as a potential strategy NSCLC treatment. In present study, mansonone G (MG), naturally occurring quinone-containing compound, and semi-synthetic ether derivatives were subjected investigate anticancer effects on human lines expressing wild-type EGFR...