A5001301143- Biochemical Analysis and Sensing Techniques
- RNA Research and Splicing
- RNA and protein synthesis mechanisms
- Monoclonal and Polyclonal Antibodies Research
- Cancer Immunotherapy and Biomarkers
- Receptor Mechanisms and Signaling
- Diverse Scientific Research Studies
- Complementary and Alternative Medicine Studies
- vaccines and immunoinformatics approaches
- T-cell and B-cell Immunology
- Phytochemistry and Bioactivity Studies
- HIV/AIDS drug development and treatment
- Protein Structure and Dynamics
- Cancer therapeutics and mechanisms
- Hepatitis C virus research
- Silk-based biomaterials and applications
- CAR-T cell therapy research
- interferon and immune responses
- 3D Printing in Biomedical Research
- Herbal Medicine Research Studies
- Olfactory and Sensory Function Studies
- Computational Drug Discovery Methods
- HER2/EGFR in Cancer Research
- Immunotherapy and Immune Responses
- HIV Research and Treatment
Walailak University
2024
Mahidol University
2024
Chulalongkorn University
2018-2023
Abstract Breast cancer stands as a formidable global health challenge for women. While neoantigens exhibit efficacy in activating T cells specific to and instigating anti-tumor immune responses, the accuracy of neoantigen prediction remains suboptimal. In this study, we identified from patient-derived breast cells, PC-B-142CA PC-B-148CA utilizing whole-genome RNA sequencing. The pVAC-Seq pipeline was employed, with minor modification incorporating criteria (1) binding affinity mutant (MT)...
The human T1R2-T1R3 sweet taste receptor (STR) plays an important role in recognizing various low-molecular-weight sweet-tasting sugars and proteins, resulting the release of intracellular heterotrimeric G protein that turn leads to perception. Xylitol sorbitol, which are naturally occurring sugar alcohols (polyols) found many fruits vegetables, exhibit potential caries-reducing effect widely used for diabetic patients as low-calorie sweeteners. In present study, computational tools were...
Targeted cancer therapy has become one of the high potential treatments. Human topoisomerase II (hTopoII), which catalyzes cleavage and rejoining double-stranded DNA, is an important molecular target for development novel therapeutics. In order to diversify pharmacological activity chalcones extend scaffold inhibitors, a series was screened against hTopoIIα by computational techniques, subsequently tested their in vitro cytotoxicity. From experimental IC50 values, chalcone 3d showed...
Abstract The Musashi (MSI) family of RNA-binding proteins, comprising the two homologs Musashi-1 (MSI1) and Musashi-2 (MSI2), typically regulates translation is involved in cell proliferation tumorigenesis. MSI proteins contain ribonucleoprotein-like domains, RBD1 RBD2, that bind single-stranded RNA motifs with a central UAG trinucleotide high affinity specificity. finding also promotes replication Zika virus, neurotropic Flavivirus, has triggered further investigations biochemical...
Abstract An efficient structural refinement technique for protein-RNA complexes is proposed based on a combination of AI-based modeling and flexible docking. Specifically, an enhanced sampling method called parallel cascade selection molecular dynamics (PaCS-MD) was extended to include docking construct from those obtained by (AlphaFold2). With the present technique, conformational RNA regions accelerated PaCS-MD, enabling one plausible models complexes. For demonstration, PaCS-MD...
Neurodegenerative diseases (NDDs) are marked by progressive degeneration of neurons within the central nervous system. A notable rise in prevalence NDDs has been noticed recent past. There is an undeniable requirement for discovery innovative therapies aimed at treating NDDs, as current medications predominantly address symptoms rather than provide cures. Approved often experience a decline therapeutic efficacy over time and associated with significant side effects. The investigation...
Hepatitis C virus (HCV) NS3/4A serine protease is a promising drug target for the discovery of anti-HCV drugs. However, its amino acid mutations, particularly A156T, commonly lead to rapid emergence resistance. Paritaprevir and glecaprevir, newly FDA-approved HCV drugs, exhibit distinct resistance profiles against A156T mutation protease. To illustrate their different molecular mechanisms, dynamics simulations binding free energy calculations were carried out on two compounds complexed with...